Genetic and Epigenetic Regulations of Tumor Progression and Metastasis
Genetic aberrations and epigenetic modifications are critical drivers of cancer progression and metastasis. Although recurrent mutations in primary and metastatic cancers have been shown to be concordant, there are several metastasis-associated mutations responsible for resistance to specific therap...
Αποθηκεύτηκε σε:
| Μορφή: | Online |
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| Γλώσσα: | Αγγλικά |
| Έκδοση: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Θέματα: | |
| Διαθέσιμο Online: | ONIX_20230511_9783036571850_25 |
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| _version_ | 1869515625860169728 |
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| collection | Directory of Open Access Books |
| description | Genetic aberrations and epigenetic modifications are critical drivers of cancer progression and metastasis. Although recurrent mutations in primary and metastatic cancers have been shown to be concordant, there are several metastasis-associated mutations responsible for resistance to specific therapies that are frequently located in genes that regulate DNA methylation and chromatin modifications. Recent studies have shown that distinct subgroups of poor-prognosis tumors lack genetic alterations but are epigenetically regulated, pointing to the critical role of epigenetic modifications in cancer progression. This Special Issue provides novel insights into the mechanisms underlying processes associated with cancer cell plasticity and the development of metastatic disease. |
| format | Online |
| id | doab-20.500.12854ir-100008 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1000082024-03-31T13:10:37Z Genetic and Epigenetic Regulations of Tumor Progression and Metastasis Smolkova, Bozena Earl, Julie Kataki, Agapi prostate cancer metastasis epithelial-to-mesenchymal transition (EMT) partial-EMT (p-EMT) Zeb1 DNA methylation 5-azacytidine lung adenocarcinoma brain metastasis omics data analysis CDKN2A p16 invasive ductal breast cancer CDH1 gene EMT genes miRNA and mRNA expression E-cadherin HTR2B STAT proteins uveal melanoma promoter gene transcription PDAC inflammation hypoxia epithelial-to-mesenchymal transition cancer proliferation hepatocellular carcinoma engineered exosomes diagnostic biomarker cancer therapy angiogenesis pericytes adipose tissue cell adhesion endothelial cells breast cancer metastatic cascade intra-tumor heterogeneity mutational profile adaptive responses autophagy tumor mutational burden tumor microenvironment waterpipe smoke lung cancer n/a CYSLTR1 CYSLTR2 methylation prognosis colorectal cancer EMT thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology Genetic aberrations and epigenetic modifications are critical drivers of cancer progression and metastasis. Although recurrent mutations in primary and metastatic cancers have been shown to be concordant, there are several metastasis-associated mutations responsible for resistance to specific therapies that are frequently located in genes that regulate DNA methylation and chromatin modifications. Recent studies have shown that distinct subgroups of poor-prognosis tumors lack genetic alterations but are epigenetically regulated, pointing to the critical role of epigenetic modifications in cancer progression. This Special Issue provides novel insights into the mechanisms underlying processes associated with cancer cell plasticity and the development of metastatic disease. 2023-05-11T17:16:26Z 2023-05-11T17:16:26Z 2023 book ONIX_20230511_9783036571850_25 9783036571850 9783036571843 https://directory.doabooks.org/handle/20.500.12854/100008 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7101 https://mdpi.com/books/pdfview/book/7101 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7184-3 10.3390/books978-3-0365-7184-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036571850 9783036571843 208 Basel open access |
| spellingShingle | prostate cancer metastasis epithelial-to-mesenchymal transition (EMT) partial-EMT (p-EMT) Zeb1 DNA methylation 5-azacytidine lung adenocarcinoma brain metastasis omics data analysis CDKN2A p16 invasive ductal breast cancer CDH1 gene EMT genes miRNA and mRNA expression E-cadherin HTR2B STAT proteins uveal melanoma promoter gene transcription PDAC inflammation hypoxia epithelial-to-mesenchymal transition cancer proliferation hepatocellular carcinoma engineered exosomes diagnostic biomarker cancer therapy angiogenesis pericytes adipose tissue cell adhesion endothelial cells breast cancer metastatic cascade intra-tumor heterogeneity mutational profile adaptive responses autophagy tumor mutational burden tumor microenvironment waterpipe smoke lung cancer n/a CYSLTR1 CYSLTR2 methylation prognosis colorectal cancer EMT thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology Genetic and Epigenetic Regulations of Tumor Progression and Metastasis |
| title | Genetic and Epigenetic Regulations of Tumor Progression and Metastasis |
| title_full | Genetic and Epigenetic Regulations of Tumor Progression and Metastasis |
| title_fullStr | Genetic and Epigenetic Regulations of Tumor Progression and Metastasis |
| title_full_unstemmed | Genetic and Epigenetic Regulations of Tumor Progression and Metastasis |
| title_short | Genetic and Epigenetic Regulations of Tumor Progression and Metastasis |
| title_sort | genetic and epigenetic regulations of tumor progression and metastasis |
| topic | prostate cancer metastasis epithelial-to-mesenchymal transition (EMT) partial-EMT (p-EMT) Zeb1 DNA methylation 5-azacytidine lung adenocarcinoma brain metastasis omics data analysis CDKN2A p16 invasive ductal breast cancer CDH1 gene EMT genes miRNA and mRNA expression E-cadherin HTR2B STAT proteins uveal melanoma promoter gene transcription PDAC inflammation hypoxia epithelial-to-mesenchymal transition cancer proliferation hepatocellular carcinoma engineered exosomes diagnostic biomarker cancer therapy angiogenesis pericytes adipose tissue cell adhesion endothelial cells breast cancer metastatic cascade intra-tumor heterogeneity mutational profile adaptive responses autophagy tumor mutational burden tumor microenvironment waterpipe smoke lung cancer n/a CYSLTR1 CYSLTR2 methylation prognosis colorectal cancer EMT thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| topic_facet | prostate cancer metastasis epithelial-to-mesenchymal transition (EMT) partial-EMT (p-EMT) Zeb1 DNA methylation 5-azacytidine lung adenocarcinoma brain metastasis omics data analysis CDKN2A p16 invasive ductal breast cancer CDH1 gene EMT genes miRNA and mRNA expression E-cadherin HTR2B STAT proteins uveal melanoma promoter gene transcription PDAC inflammation hypoxia epithelial-to-mesenchymal transition cancer proliferation hepatocellular carcinoma engineered exosomes diagnostic biomarker cancer therapy angiogenesis pericytes adipose tissue cell adhesion endothelial cells breast cancer metastatic cascade intra-tumor heterogeneity mutational profile adaptive responses autophagy tumor mutational burden tumor microenvironment waterpipe smoke lung cancer n/a CYSLTR1 CYSLTR2 methylation prognosis colorectal cancer EMT thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| url | ONIX_20230511_9783036571850_25 |