Multicomponent Pharmaceutical Solids
Multicomponent pharmaceutical materials are solids in which at least one component is an active pharmaceutical ingredient (API). This kind of pharmaceutical solid has attracted interest in the past decade as a promising alternative to the laborious and expensive process of traditional pipeline drug...
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| Materiálatiipa: | Online |
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| Giella: | eaŋgalasgiella |
| Almmustuhtton: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Fáttát: | |
| Liŋkkat: | ONIX_20230511_9783036572161_80 |
| Fáddágilkorat: |
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| _version_ | 1869523085805223936 |
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| collection | Directory of Open Access Books |
| description | Multicomponent pharmaceutical materials are solids in which at least one component is an active pharmaceutical ingredient (API). This kind of pharmaceutical solid has attracted interest in the past decade as a promising alternative to the laborious and expensive process of traditional pipeline drug development. The application of crystal engineering techniques into the design of pharmaceutical salts, co-crystals, and other multicomponent materials, in addition to the achievement of more environmentally friendly synthetic approaches, has succeeded in modulating the physicochemical, mechanical, and pharmacokinetic properties of drugs, thereby working toward the enhancement of their clinical performance. This Special Issue welcomed original research articles and reviews devoted to all aspects related to the field of multicomponent pharmaceutical solids. Our interests include the fundamentals of applied research, using theoretical and experimental approaches, the development of synthetic methods, the screening of multicomponent materials, structure–activity rationale, the salt–co-crystal continuum identification, the enhancement in physicochemical/mechanical/pharmacokinetic performance, as well as the functionality and applications of multicomponent pharmaceuticals solids. |
| format | Online |
| id | doab-20.500.12854ir-100063 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1000632024-03-28T03:32:40Z Multicomponent Pharmaceutical Solids Choquesillo-Lazarte, Duane Dominguez-Martin, Alicia solvate polymorph bilastine crystal structure determination single crystal X-ray diffraction structure determination from powder diffraction aripiprazole multicomponent crystal crystal structure solubility drug–drug cocrystal furosemide ethenzamide piroxicam mechanochemical synthesis amorphous drug characterization methods crystallization physical stability molecular mobility aminoglutethimide eutectic mixture melt phase diagram nucleobases multicomponent solids crystal engineering DFT H-bonding pyridinecarboxamides cocrystals mandelic acid X-ray structure DFT calculations xanthines theophylline squaric acid controlled release dissolution lidocaine mechanochemistry multicomponent materials API pharmaceutical solids diclofenac pharmaceutical solid forms n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PH Physics Multicomponent pharmaceutical materials are solids in which at least one component is an active pharmaceutical ingredient (API). This kind of pharmaceutical solid has attracted interest in the past decade as a promising alternative to the laborious and expensive process of traditional pipeline drug development. The application of crystal engineering techniques into the design of pharmaceutical salts, co-crystals, and other multicomponent materials, in addition to the achievement of more environmentally friendly synthetic approaches, has succeeded in modulating the physicochemical, mechanical, and pharmacokinetic properties of drugs, thereby working toward the enhancement of their clinical performance. This Special Issue welcomed original research articles and reviews devoted to all aspects related to the field of multicomponent pharmaceutical solids. Our interests include the fundamentals of applied research, using theoretical and experimental approaches, the development of synthetic methods, the screening of multicomponent materials, structure–activity rationale, the salt–co-crystal continuum identification, the enhancement in physicochemical/mechanical/pharmacokinetic performance, as well as the functionality and applications of multicomponent pharmaceuticals solids. 2023-05-11T17:18:59Z 2023-05-11T17:18:59Z 2023 book ONIX_20230511_9783036572161_80 9783036572161 9783036572178 https://directory.doabooks.org/handle/20.500.12854/100063 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7156 https://mdpi.com/books/pdfview/book/7156 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7217-8 10.3390/books978-3-0365-7217-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036572161 9783036572178 178 Basel open access |
| spellingShingle | solvate polymorph bilastine crystal structure determination single crystal X-ray diffraction structure determination from powder diffraction aripiprazole multicomponent crystal crystal structure solubility drug–drug cocrystal furosemide ethenzamide piroxicam mechanochemical synthesis amorphous drug characterization methods crystallization physical stability molecular mobility aminoglutethimide eutectic mixture melt phase diagram nucleobases multicomponent solids crystal engineering DFT H-bonding pyridinecarboxamides cocrystals mandelic acid X-ray structure DFT calculations xanthines theophylline squaric acid controlled release dissolution lidocaine mechanochemistry multicomponent materials API pharmaceutical solids diclofenac pharmaceutical solid forms n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PH Physics Multicomponent Pharmaceutical Solids |
| title | Multicomponent Pharmaceutical Solids |
| title_full | Multicomponent Pharmaceutical Solids |
| title_fullStr | Multicomponent Pharmaceutical Solids |
| title_full_unstemmed | Multicomponent Pharmaceutical Solids |
| title_short | Multicomponent Pharmaceutical Solids |
| title_sort | multicomponent pharmaceutical solids |
| topic | solvate polymorph bilastine crystal structure determination single crystal X-ray diffraction structure determination from powder diffraction aripiprazole multicomponent crystal crystal structure solubility drug–drug cocrystal furosemide ethenzamide piroxicam mechanochemical synthesis amorphous drug characterization methods crystallization physical stability molecular mobility aminoglutethimide eutectic mixture melt phase diagram nucleobases multicomponent solids crystal engineering DFT H-bonding pyridinecarboxamides cocrystals mandelic acid X-ray structure DFT calculations xanthines theophylline squaric acid controlled release dissolution lidocaine mechanochemistry multicomponent materials API pharmaceutical solids diclofenac pharmaceutical solid forms n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PH Physics |
| topic_facet | solvate polymorph bilastine crystal structure determination single crystal X-ray diffraction structure determination from powder diffraction aripiprazole multicomponent crystal crystal structure solubility drug–drug cocrystal furosemide ethenzamide piroxicam mechanochemical synthesis amorphous drug characterization methods crystallization physical stability molecular mobility aminoglutethimide eutectic mixture melt phase diagram nucleobases multicomponent solids crystal engineering DFT H-bonding pyridinecarboxamides cocrystals mandelic acid X-ray structure DFT calculations xanthines theophylline squaric acid controlled release dissolution lidocaine mechanochemistry multicomponent materials API pharmaceutical solids diclofenac pharmaceutical solid forms n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PH Physics |
| url | ONIX_20230511_9783036572161_80 |