Impacts of Molecular Structure on Nucleic Acid-Protein Interactions
Interactions between nucleic acids and proteins are essential requirements for the viability of cellular life because they are indispensable for many basic biological processes. DNA is typically presented as a specific double-stranded helical structure, but nucleic acids have great structural flexib...
Sábháilte in:
| Formáid: | Online |
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| Teanga: | Béarla |
| Foilsithe / Cruthaithe: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Ábhair: | |
| Rochtain ar líne: | ONIX_20230511_9783036574455_108 |
| Clibeanna: |
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
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| _version_ | 1869528505469894656 |
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| collection | Directory of Open Access Books |
| description | Interactions between nucleic acids and proteins are essential requirements for the viability of cellular life because they are indispensable for many basic biological processes. DNA is typically presented as a specific double-stranded helical structure, but nucleic acids have great structural flexibility. Current knowledge demonstrates that the structural conformations of nucleic acids play critical roles in protein–DNA interactions. This book presents a collection of research findings published in the Special Issue of the International Journal of Molecular Sciences, titled “Impacts of Molecular Structure on Nucleic Acid-Protein Interactions”.The breadth of research findings reported here demonstrates that the structural flexibility of nucleic acids plays critical roles in their interactions with proteins, with important implications across a range of human diseases, including cancer and some infectious diseases.Prof. Richard BowaterUniversity of East Anglia, Norwich, United KingdomProf. Václav BrázdaInstitute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic |
| format | Online |
| id | doab-20.500.12854ir-100091 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1000912024-04-11T15:11:13Z Impacts of Molecular Structure on Nucleic Acid-Protein Interactions Brazda, Vaclav Bowater, Richard DNA RNA protein binding G-quadruplex triplex i-motif Z-DNA Z-RNA cruciform amino acid composition COVID-19 SARS-CoV-2 coronavirus CNBP virus bioinformatics coevolution host dsDNA G4Hunter evolution plant science nucleic acids circular dichroism UV light ligand rhodamine thiazole orange thioflavin T p53 aging longevity comparative analysis protein sequence Drosophila polytene chromosomes Canton-S agnostic ectopic pairing 1.688 repeats 372-bp repeats fragile X-associated primary ovarian insufficiency (FXPOI) fragile X-associated tremor/ataxia syndrome (FXTAS) fragile X syndrome (FXS) repeat instability repeat expansion chromosome fragility RNA gain-of-function repeat-associated non-AUG (RAN) translation repeat-mediated gene silencing Zα domain orthogonal representation algorithm toehold switch arithmetic operation RNA–RNA interaction molecular computing reversible computing DNA base sequence DNA structure DNA supercoiling epigenetics genome stability inverted repeat replication transcription nucleic acid–protein interactions thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology Interactions between nucleic acids and proteins are essential requirements for the viability of cellular life because they are indispensable for many basic biological processes. DNA is typically presented as a specific double-stranded helical structure, but nucleic acids have great structural flexibility. Current knowledge demonstrates that the structural conformations of nucleic acids play critical roles in protein–DNA interactions. This book presents a collection of research findings published in the Special Issue of the International Journal of Molecular Sciences, titled “Impacts of Molecular Structure on Nucleic Acid-Protein Interactions”.The breadth of research findings reported here demonstrates that the structural flexibility of nucleic acids plays critical roles in their interactions with proteins, with important implications across a range of human diseases, including cancer and some infectious diseases.Prof. Richard BowaterUniversity of East Anglia, Norwich, United KingdomProf. Václav BrázdaInstitute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic 2023-05-11T17:20:24Z 2023-05-11T17:20:24Z 2023 book ONIX_20230511_9783036574455_108 9783036574455 9783036574448 https://directory.doabooks.org/handle/20.500.12854/100091 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7184 https://mdpi.com/books/pdfview/book/7184 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7444-8 10.3390/books978-3-0365-7444-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036574455 9783036574448 216 Basel open access |
| spellingShingle | DNA RNA protein binding G-quadruplex triplex i-motif Z-DNA Z-RNA cruciform amino acid composition COVID-19 SARS-CoV-2 coronavirus CNBP virus bioinformatics coevolution host dsDNA G4Hunter evolution plant science nucleic acids circular dichroism UV light ligand rhodamine thiazole orange thioflavin T p53 aging longevity comparative analysis protein sequence Drosophila polytene chromosomes Canton-S agnostic ectopic pairing 1.688 repeats 372-bp repeats fragile X-associated primary ovarian insufficiency (FXPOI) fragile X-associated tremor/ataxia syndrome (FXTAS) fragile X syndrome (FXS) repeat instability repeat expansion chromosome fragility RNA gain-of-function repeat-associated non-AUG (RAN) translation repeat-mediated gene silencing Zα domain orthogonal representation algorithm toehold switch arithmetic operation RNA–RNA interaction molecular computing reversible computing DNA base sequence DNA structure DNA supercoiling epigenetics genome stability inverted repeat replication transcription nucleic acid–protein interactions thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology Impacts of Molecular Structure on Nucleic Acid-Protein Interactions |
| title | Impacts of Molecular Structure on Nucleic Acid-Protein Interactions |
| title_full | Impacts of Molecular Structure on Nucleic Acid-Protein Interactions |
| title_fullStr | Impacts of Molecular Structure on Nucleic Acid-Protein Interactions |
| title_full_unstemmed | Impacts of Molecular Structure on Nucleic Acid-Protein Interactions |
| title_short | Impacts of Molecular Structure on Nucleic Acid-Protein Interactions |
| title_sort | impacts of molecular structure on nucleic acid protein interactions |
| topic | DNA RNA protein binding G-quadruplex triplex i-motif Z-DNA Z-RNA cruciform amino acid composition COVID-19 SARS-CoV-2 coronavirus CNBP virus bioinformatics coevolution host dsDNA G4Hunter evolution plant science nucleic acids circular dichroism UV light ligand rhodamine thiazole orange thioflavin T p53 aging longevity comparative analysis protein sequence Drosophila polytene chromosomes Canton-S agnostic ectopic pairing 1.688 repeats 372-bp repeats fragile X-associated primary ovarian insufficiency (FXPOI) fragile X-associated tremor/ataxia syndrome (FXTAS) fragile X syndrome (FXS) repeat instability repeat expansion chromosome fragility RNA gain-of-function repeat-associated non-AUG (RAN) translation repeat-mediated gene silencing Zα domain orthogonal representation algorithm toehold switch arithmetic operation RNA–RNA interaction molecular computing reversible computing DNA base sequence DNA structure DNA supercoiling epigenetics genome stability inverted repeat replication transcription nucleic acid–protein interactions thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology |
| topic_facet | DNA RNA protein binding G-quadruplex triplex i-motif Z-DNA Z-RNA cruciform amino acid composition COVID-19 SARS-CoV-2 coronavirus CNBP virus bioinformatics coevolution host dsDNA G4Hunter evolution plant science nucleic acids circular dichroism UV light ligand rhodamine thiazole orange thioflavin T p53 aging longevity comparative analysis protein sequence Drosophila polytene chromosomes Canton-S agnostic ectopic pairing 1.688 repeats 372-bp repeats fragile X-associated primary ovarian insufficiency (FXPOI) fragile X-associated tremor/ataxia syndrome (FXTAS) fragile X syndrome (FXS) repeat instability repeat expansion chromosome fragility RNA gain-of-function repeat-associated non-AUG (RAN) translation repeat-mediated gene silencing Zα domain orthogonal representation algorithm toehold switch arithmetic operation RNA–RNA interaction molecular computing reversible computing DNA base sequence DNA structure DNA supercoiling epigenetics genome stability inverted repeat replication transcription nucleic acid–protein interactions thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology |
| url | ONIX_20230511_9783036574455_108 |