Targeting Inflammation and Inflammatory-Related Diseases with Natural Bioactives
Inflammation is a complex biological response to injury as a result of different stimuli such as pathogens, damaged cells, or irritants. Inflammatory injuries induce the release of a variety of systemic mediators, cytokines, and chemokines that orchestrate cellular infiltration, consequentially brin...
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| Format: | Online |
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| Sprache: | Englisch |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| description | Inflammation is a complex biological response to injury as a result of different stimuli such as pathogens, damaged cells, or irritants. Inflammatory injuries induce the release of a variety of systemic mediators, cytokines, and chemokines that orchestrate cellular infiltration, consequentially bringing about the resolution of inflammatory responses and the restoration of tissue integrity. However, persistent inflammatory stimuli or the disregulation of the mechanisms of the resolution phase can lead to chronic inflammation and inflammatory-based diseases. Nowadays, commercially approved anti-inflammatory drugs are represented by nonsteroidal anti-inflammatory drugs (NSAID); glucocorticoids (SAID); and, in some cases, immunosuppressant and/or biological drugs. These agents are effective for the relief of the main inflammatory symptoms. However, they induce severe side effects, and most of them are inadequate for chronic use. Starting from these premises, the demand for new, effective, and safe anti-inflammatory drugs has led research in new therapeutic directions. The recent and emerging scientific community slant is oriented towards natural products/compounds that could represent a boon for the discovery of new active molecules and for the development of new drugs and potentially useful therapeutic agents in different inflammatory-related diseases. We hope that it will stimulate the interest of the scientific community involved in studying the effects of natural and synthetic compounds in different fields of interest such as acute and chronic inflammation, inflammatory pain, inflammation-related diseases (e.g., autoimmune diseases), amongst others. |
| format | Online |
| id | doab-20.500.12854ir-100094 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1000942024-03-31T13:08:10Z Targeting Inflammation and Inflammatory-Related Diseases with Natural Bioactives Maione, Francesco Padina boryana alginic acid particulate matter skin inflammation chelation BELFRIT immunity mPGES-1 natural compounds Th17 sulforaphane osteoclastogenesis autophagy JNK signaling pathway baicalin Glaesserella parasuis tight junctions peritoneum piglets calceolarioside A nociception phenylpropanoid glycosides Calceolaria citropten colitis T cell activation intestinal cell activation anti-inflammation MAPK diabetes mellitus infertility oxidative stress Portulaca oleracea Crepis Asteraceae LC-MS NMR cichoric acid phenolic acid biological activity mouse paw edema antihyperlipidemic NLRP3 IL-1β natural products docking design Allium cepa L. quercetin bioaccessibility design of experiments anti-inflammatory activity thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Inflammation is a complex biological response to injury as a result of different stimuli such as pathogens, damaged cells, or irritants. Inflammatory injuries induce the release of a variety of systemic mediators, cytokines, and chemokines that orchestrate cellular infiltration, consequentially bringing about the resolution of inflammatory responses and the restoration of tissue integrity. However, persistent inflammatory stimuli or the disregulation of the mechanisms of the resolution phase can lead to chronic inflammation and inflammatory-based diseases. Nowadays, commercially approved anti-inflammatory drugs are represented by nonsteroidal anti-inflammatory drugs (NSAID); glucocorticoids (SAID); and, in some cases, immunosuppressant and/or biological drugs. These agents are effective for the relief of the main inflammatory symptoms. However, they induce severe side effects, and most of them are inadequate for chronic use. Starting from these premises, the demand for new, effective, and safe anti-inflammatory drugs has led research in new therapeutic directions. The recent and emerging scientific community slant is oriented towards natural products/compounds that could represent a boon for the discovery of new active molecules and for the development of new drugs and potentially useful therapeutic agents in different inflammatory-related diseases. We hope that it will stimulate the interest of the scientific community involved in studying the effects of natural and synthetic compounds in different fields of interest such as acute and chronic inflammation, inflammatory pain, inflammation-related diseases (e.g., autoimmune diseases), amongst others. 2023-05-11T17:20:32Z 2023-05-11T17:20:32Z 2023 book ONIX_20230511_9783036572970_111 9783036572970 9783036572963 https://directory.doabooks.org/handle/20.500.12854/100094 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7187 https://mdpi.com/books/pdfview/book/7187 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7296-3 10.3390/books978-3-0365-7296-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036572970 9783036572963 166 Basel open access |
| spellingShingle | Padina boryana alginic acid particulate matter skin inflammation chelation BELFRIT immunity mPGES-1 natural compounds Th17 sulforaphane osteoclastogenesis autophagy JNK signaling pathway baicalin Glaesserella parasuis tight junctions peritoneum piglets calceolarioside A nociception phenylpropanoid glycosides Calceolaria citropten colitis T cell activation intestinal cell activation anti-inflammation MAPK diabetes mellitus infertility oxidative stress Portulaca oleracea Crepis Asteraceae LC-MS NMR cichoric acid phenolic acid biological activity mouse paw edema antihyperlipidemic NLRP3 IL-1β natural products docking design Allium cepa L. quercetin bioaccessibility design of experiments anti-inflammatory activity thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Targeting Inflammation and Inflammatory-Related Diseases with Natural Bioactives |
| title | Targeting Inflammation and Inflammatory-Related Diseases with Natural Bioactives |
| title_full | Targeting Inflammation and Inflammatory-Related Diseases with Natural Bioactives |
| title_fullStr | Targeting Inflammation and Inflammatory-Related Diseases with Natural Bioactives |
| title_full_unstemmed | Targeting Inflammation and Inflammatory-Related Diseases with Natural Bioactives |
| title_short | Targeting Inflammation and Inflammatory-Related Diseases with Natural Bioactives |
| title_sort | targeting inflammation and inflammatory related diseases with natural bioactives |
| topic | Padina boryana alginic acid particulate matter skin inflammation chelation BELFRIT immunity mPGES-1 natural compounds Th17 sulforaphane osteoclastogenesis autophagy JNK signaling pathway baicalin Glaesserella parasuis tight junctions peritoneum piglets calceolarioside A nociception phenylpropanoid glycosides Calceolaria citropten colitis T cell activation intestinal cell activation anti-inflammation MAPK diabetes mellitus infertility oxidative stress Portulaca oleracea Crepis Asteraceae LC-MS NMR cichoric acid phenolic acid biological activity mouse paw edema antihyperlipidemic NLRP3 IL-1β natural products docking design Allium cepa L. quercetin bioaccessibility design of experiments anti-inflammatory activity thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | Padina boryana alginic acid particulate matter skin inflammation chelation BELFRIT immunity mPGES-1 natural compounds Th17 sulforaphane osteoclastogenesis autophagy JNK signaling pathway baicalin Glaesserella parasuis tight junctions peritoneum piglets calceolarioside A nociception phenylpropanoid glycosides Calceolaria citropten colitis T cell activation intestinal cell activation anti-inflammation MAPK diabetes mellitus infertility oxidative stress Portulaca oleracea Crepis Asteraceae LC-MS NMR cichoric acid phenolic acid biological activity mouse paw edema antihyperlipidemic NLRP3 IL-1β natural products docking design Allium cepa L. quercetin bioaccessibility design of experiments anti-inflammatory activity thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | ONIX_20230511_9783036572970_111 |