Proteostasis and Proteolysis
Proteins are the key decision-making workforce for practically all cellular signals. The precise equilibrium between protein translation, folding, function and timely degradation, also known as "proteostasis", determine cellular health as well as organismal maintenance and survival. Loss of cellular...
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| Formato: | Online |
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| Idioma: | inglês |
| Publicado em: |
Taylor & Francis
2023
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| Acesso em linha: | https://library.oapen.org/handle/20.500.12657/62946 |
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| collection | Directory of Open Access Books |
| description | Proteins are the key decision-making workforce for practically all cellular signals. The precise equilibrium between protein translation, folding, function and timely degradation, also known as "proteostasis", determine cellular health as well as organismal maintenance and survival. Loss of cellular proteostasis is linked with physiological processes of deterioration such as aging, with conditions characterized by supraphysiological oxidative stress as well as with illness, including age-related diseases, neurodegeneration, inflammation, dystrophies and cancer. This book includes 18 chapters logically organized to allow comprehensive understanding of how maintenance of proteostasis protects cellular and organismal health, and how environmental and metabolic pressure can impair proteostasis and lead to disequilibrium and disease. Each chapter contains up-to-date information on its respective topic while some of them review the interplay of certain proteostatic mechanisms, a newly arising topic. Importantly, most chapters include tangible examples of how failure of proteostasis can underlie aging and disease. We hope that the compilation of the above topics will assist both novice and experienced researchers and students to become more familiar with the subject of proteostasis. In the long run, we hope that this book will inspire its readers and eventually promote new ideas and new research studies. |
| format | Online |
| id | doab-20.500.12854ir-100138 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Taylor & Francis |
| publisherStr | Taylor & Francis |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1001382025-07-17T09:59:51Z Proteostasis and Proteolysis Chondrogianni, Niki PICK, ELAH Gioran, Anna ad, age, alejandro, alihamze, anna, arantxa, aspects, assembly, Athanasopouloi, autophagy, between, cell, central, chaerone, chapter, Chondrogianni, complex, concluding, conculsions, contents, control, crosstalk, current, deciphering, definition, degradation, Diana, diseases, during, Efstathios, elF5A, Elah, Elisabeth, Factors, Farras, fathinajafabadi, Ferrando, Ferriz, folding, functions, future, gioran, gonos, heat, heidi, integrity, interplay, introsuction, irreversible, judith, kapetanou, kinetic, leading, localized, Marianna, Martinez, mechanisms, MicroRNAs, misfolding, molecular, motifs, network, Kiki, Olzscha, organellar, other, oxidative, panfilova,pathway, pauses, perspectives, pick, polu, pro, process, Proteasome, protein, proteinopathies, proteolysis, proteome, proteostasis, proteostatic, quality, references, regulation, regulators, related, remarks, rescues, response, reversible, ribosomal, riemer, rosa, RQC, S, shock,significance, sophia, stalling, stress, system, systemic, systems, table, targeting, term, thermodynamic, transcriptional , translation, translational, treatments, ubiquitin, unfolded thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Proteins are the key decision-making workforce for practically all cellular signals. The precise equilibrium between protein translation, folding, function and timely degradation, also known as "proteostasis", determine cellular health as well as organismal maintenance and survival. Loss of cellular proteostasis is linked with physiological processes of deterioration such as aging, with conditions characterized by supraphysiological oxidative stress as well as with illness, including age-related diseases, neurodegeneration, inflammation, dystrophies and cancer. This book includes 18 chapters logically organized to allow comprehensive understanding of how maintenance of proteostasis protects cellular and organismal health, and how environmental and metabolic pressure can impair proteostasis and lead to disequilibrium and disease. Each chapter contains up-to-date information on its respective topic while some of them review the interplay of certain proteostatic mechanisms, a newly arising topic. Importantly, most chapters include tangible examples of how failure of proteostasis can underlie aging and disease. We hope that the compilation of the above topics will assist both novice and experienced researchers and students to become more familiar with the subject of proteostasis. In the long run, we hope that this book will inspire its readers and eventually promote new ideas and new research studies. 2023-05-12T04:02:59Z 2023-05-12T04:02:59Z 2023-05-11T13:59:25Z 2022 book https://library.oapen.org/handle/20.500.12657/62946 9780367499327 9780367499334 9781003048138 https://directory.doabooks.org/handle/20.500.12854/100138 eng open access Taylor & Francis CRC Press 10.1201/9781003048138 10.1201/9781003048138 fa69b019-f4ee-4979-8d42-c6b6c476b5f0 Chapter 2 Protein Folding And Misfolding 9780367499327 9780367499334 9781003048138 CRC Press open access |
| spellingShingle | ad, age, alejandro, alihamze, anna, arantxa, aspects, assembly, Athanasopouloi, autophagy, between, cell, central, chaerone, chapter, Chondrogianni, complex, concluding, conculsions, contents, control, crosstalk, current, deciphering, definition, degradation, Diana, diseases, during, Efstathios, elF5A, Elah, Elisabeth, Factors, Farras, fathinajafabadi, Ferrando, Ferriz, folding, functions, future, gioran, gonos, heat, heidi, integrity, interplay, introsuction, irreversible, judith, kapetanou, kinetic, leading, localized, Marianna, Martinez, mechanisms, MicroRNAs, misfolding, molecular, motifs, network, Kiki, Olzscha, organellar, other, oxidative, panfilova,pathway, pauses, perspectives, pick, polu, pro, process, Proteasome, protein, proteinopathies, proteolysis, proteome, proteostasis, proteostatic, quality, references, regulation, regulators, related, remarks, rescues, response, reversible, ribosomal, riemer, rosa, RQC, S, shock,significance, sophia, stalling, stress, system, systemic, systems, table, targeting, term, thermodynamic, transcriptional , translation, translational, treatments, ubiquitin, unfolded thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Proteostasis and Proteolysis |
| title | Proteostasis and Proteolysis |
| title_full | Proteostasis and Proteolysis |
| title_fullStr | Proteostasis and Proteolysis |
| title_full_unstemmed | Proteostasis and Proteolysis |
| title_short | Proteostasis and Proteolysis |
| title_sort | proteostasis and proteolysis |
| topic | ad, age, alejandro, alihamze, anna, arantxa, aspects, assembly, Athanasopouloi, autophagy, between, cell, central, chaerone, chapter, Chondrogianni, complex, concluding, conculsions, contents, control, crosstalk, current, deciphering, definition, degradation, Diana, diseases, during, Efstathios, elF5A, Elah, Elisabeth, Factors, Farras, fathinajafabadi, Ferrando, Ferriz, folding, functions, future, gioran, gonos, heat, heidi, integrity, interplay, introsuction, irreversible, judith, kapetanou, kinetic, leading, localized, Marianna, Martinez, mechanisms, MicroRNAs, misfolding, molecular, motifs, network, Kiki, Olzscha, organellar, other, oxidative, panfilova,pathway, pauses, perspectives, pick, polu, pro, process, Proteasome, protein, proteinopathies, proteolysis, proteome, proteostasis, proteostatic, quality, references, regulation, regulators, related, remarks, rescues, response, reversible, ribosomal, riemer, rosa, RQC, S, shock,significance, sophia, stalling, stress, system, systemic, systems, table, targeting, term, thermodynamic, transcriptional , translation, translational, treatments, ubiquitin, unfolded thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | ad, age, alejandro, alihamze, anna, arantxa, aspects, assembly, Athanasopouloi, autophagy, between, cell, central, chaerone, chapter, Chondrogianni, complex, concluding, conculsions, contents, control, crosstalk, current, deciphering, definition, degradation, Diana, diseases, during, Efstathios, elF5A, Elah, Elisabeth, Factors, Farras, fathinajafabadi, Ferrando, Ferriz, folding, functions, future, gioran, gonos, heat, heidi, integrity, interplay, introsuction, irreversible, judith, kapetanou, kinetic, leading, localized, Marianna, Martinez, mechanisms, MicroRNAs, misfolding, molecular, motifs, network, Kiki, Olzscha, organellar, other, oxidative, panfilova,pathway, pauses, perspectives, pick, polu, pro, process, Proteasome, protein, proteinopathies, proteolysis, proteome, proteostasis, proteostatic, quality, references, regulation, regulators, related, remarks, rescues, response, reversible, ribosomal, riemer, rosa, RQC, S, shock,significance, sophia, stalling, stress, system, systemic, systems, table, targeting, term, thermodynamic, transcriptional , translation, translational, treatments, ubiquitin, unfolded thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | https://library.oapen.org/handle/20.500.12657/62946 |