Optic Neuropathies
Optic neuropathies are conditions in which there is damage to the optic nerve (ON) caused by a variety of causes, including glaucoma, inflammation, gene abnormalities, ischemia, trauma, and toxicity. ON damage triggers a process of axon degeneration, inflammatory cytokine upregulation, breakdown of...
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| Formato: | Online |
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| Idioma: | inglês |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Acesso em linha: | ONIX_20230623_9783036575056_11 |
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| description | Optic neuropathies are conditions in which there is damage to the optic nerve (ON) caused by a variety of causes, including glaucoma, inflammation, gene abnormalities, ischemia, trauma, and toxicity. ON damage triggers a process of axon degeneration, inflammatory cytokine upregulation, breakdown of the blood–optic nerve barrier, and, eventually, the induction of apoptosis of retinal ganglion cells (RGCs), resulting in optic atrophy. To date, there is no effective treatment for most optic neuropathies; however, because the damage initially is axogenic, there may exist a window of therapeutic opportunity before the death of RGCs. Thus, the search for effective treatments for various optic neuropathies before there is permanent damage to prevent or limit visual dysfunction and the development of methods to stimulate axon and/or RGC regeneration to restore vision after damage has occurred is pivotal.This reprint collected 19 articles published in this Special Issue of IJMS which covers the molecular mechanisms to protect RGCs and/or axonal damage, translational research, gene therapy, regenerative medicine, and neuroprotection for glaucoma. |
| format | Online |
| id | doab-20.500.12854ir-100779 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1007792024-03-31T13:09:53Z Optic Neuropathies Tsai, Rongkung Miller, Neil R. neuroprotection retinal ganglion cells optic neuropathy glaucoma pattern electroretinogram NMO astrocytes apoptosis BID inflammation neuroimmunology erythropoietin retinal ganglion cell optic nerve protection neuromyelitis optica spectrum disease aquaporin-4 myelin oligodendrocyte glycoprotein ocular coherence tomography complement microcystic macular degeneration Müller cell astrocyte oligodendrocyte microglia optic nerve head lamina cribrosa lamina cribrosa cells scleral fibroblasts glial cells intraocular pressure rat anterior ischemic optic neuropathy model retinal ganglion cell death TBP associated factor 9 TP53 regulated inhibitor of apoptosis 1 transcriptome optic nerve epigenetics myelin regeneration oligodendrocytes atypical optic neuritis treatment typical optic neuritis MOG MS prevention retina transcription CNS repair oncomodulin myeloid cells glaucomatous optic neuropathy fibrosis miR-29 extracellular matrix optic nerve crush azithromycin NAION neural injury neural ischemia neural inflammation Leber’s hereditary optic neuropathy LHON whole exome sequencing nuclear modifier genes leber’s hereditary optic neuropathy mitochondrial disorder mitochondrial optic neuropathy hereditary optic neuropathy neuro-ophthalmology idebenone nonarteritic anterior ischemic optic neuropathy rodents gene expression models diabetes ischemic optic neuropathy pioglitazone HSF1 Klf4 Oct4 Sox2 Yamanaka factors optic nerve regeneration zebrafish oligodendrocyte precursor cells secondary degeneration oxidative stress DNA damage proliferation blood-brain barrier CNS injury optic nerve injury synaptamide A8 axonal degeneration neuronal survival visual evoked potential n/a thema EDItEUR::M Medicine and Nursing Optic neuropathies are conditions in which there is damage to the optic nerve (ON) caused by a variety of causes, including glaucoma, inflammation, gene abnormalities, ischemia, trauma, and toxicity. ON damage triggers a process of axon degeneration, inflammatory cytokine upregulation, breakdown of the blood–optic nerve barrier, and, eventually, the induction of apoptosis of retinal ganglion cells (RGCs), resulting in optic atrophy. To date, there is no effective treatment for most optic neuropathies; however, because the damage initially is axogenic, there may exist a window of therapeutic opportunity before the death of RGCs. Thus, the search for effective treatments for various optic neuropathies before there is permanent damage to prevent or limit visual dysfunction and the development of methods to stimulate axon and/or RGC regeneration to restore vision after damage has occurred is pivotal.This reprint collected 19 articles published in this Special Issue of IJMS which covers the molecular mechanisms to protect RGCs and/or axonal damage, translational research, gene therapy, regenerative medicine, and neuroprotection for glaucoma. 2023-06-23T09:40:58Z 2023-06-23T09:40:58Z 2023 book ONIX_20230623_9783036575056_11 9783036575056 9783036575049 https://directory.doabooks.org/handle/20.500.12854/100779 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7241 https://mdpi.com/books/pdfview/book/7241 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7504-9 10.3390/books978-3-0365-7504-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036575056 9783036575049 322 Basel open access |
| spellingShingle | neuroprotection retinal ganglion cells optic neuropathy glaucoma pattern electroretinogram NMO astrocytes apoptosis BID inflammation neuroimmunology erythropoietin retinal ganglion cell optic nerve protection neuromyelitis optica spectrum disease aquaporin-4 myelin oligodendrocyte glycoprotein ocular coherence tomography complement microcystic macular degeneration Müller cell astrocyte oligodendrocyte microglia optic nerve head lamina cribrosa lamina cribrosa cells scleral fibroblasts glial cells intraocular pressure rat anterior ischemic optic neuropathy model retinal ganglion cell death TBP associated factor 9 TP53 regulated inhibitor of apoptosis 1 transcriptome optic nerve epigenetics myelin regeneration oligodendrocytes atypical optic neuritis treatment typical optic neuritis MOG MS prevention retina transcription CNS repair oncomodulin myeloid cells glaucomatous optic neuropathy fibrosis miR-29 extracellular matrix optic nerve crush azithromycin NAION neural injury neural ischemia neural inflammation Leber’s hereditary optic neuropathy LHON whole exome sequencing nuclear modifier genes leber’s hereditary optic neuropathy mitochondrial disorder mitochondrial optic neuropathy hereditary optic neuropathy neuro-ophthalmology idebenone nonarteritic anterior ischemic optic neuropathy rodents gene expression models diabetes ischemic optic neuropathy pioglitazone HSF1 Klf4 Oct4 Sox2 Yamanaka factors optic nerve regeneration zebrafish oligodendrocyte precursor cells secondary degeneration oxidative stress DNA damage proliferation blood-brain barrier CNS injury optic nerve injury synaptamide A8 axonal degeneration neuronal survival visual evoked potential n/a thema EDItEUR::M Medicine and Nursing Optic Neuropathies |
| title | Optic Neuropathies |
| title_full | Optic Neuropathies |
| title_fullStr | Optic Neuropathies |
| title_full_unstemmed | Optic Neuropathies |
| title_short | Optic Neuropathies |
| title_sort | optic neuropathies |
| topic | neuroprotection retinal ganglion cells optic neuropathy glaucoma pattern electroretinogram NMO astrocytes apoptosis BID inflammation neuroimmunology erythropoietin retinal ganglion cell optic nerve protection neuromyelitis optica spectrum disease aquaporin-4 myelin oligodendrocyte glycoprotein ocular coherence tomography complement microcystic macular degeneration Müller cell astrocyte oligodendrocyte microglia optic nerve head lamina cribrosa lamina cribrosa cells scleral fibroblasts glial cells intraocular pressure rat anterior ischemic optic neuropathy model retinal ganglion cell death TBP associated factor 9 TP53 regulated inhibitor of apoptosis 1 transcriptome optic nerve epigenetics myelin regeneration oligodendrocytes atypical optic neuritis treatment typical optic neuritis MOG MS prevention retina transcription CNS repair oncomodulin myeloid cells glaucomatous optic neuropathy fibrosis miR-29 extracellular matrix optic nerve crush azithromycin NAION neural injury neural ischemia neural inflammation Leber’s hereditary optic neuropathy LHON whole exome sequencing nuclear modifier genes leber’s hereditary optic neuropathy mitochondrial disorder mitochondrial optic neuropathy hereditary optic neuropathy neuro-ophthalmology idebenone nonarteritic anterior ischemic optic neuropathy rodents gene expression models diabetes ischemic optic neuropathy pioglitazone HSF1 Klf4 Oct4 Sox2 Yamanaka factors optic nerve regeneration zebrafish oligodendrocyte precursor cells secondary degeneration oxidative stress DNA damage proliferation blood-brain barrier CNS injury optic nerve injury synaptamide A8 axonal degeneration neuronal survival visual evoked potential n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | neuroprotection retinal ganglion cells optic neuropathy glaucoma pattern electroretinogram NMO astrocytes apoptosis BID inflammation neuroimmunology erythropoietin retinal ganglion cell optic nerve protection neuromyelitis optica spectrum disease aquaporin-4 myelin oligodendrocyte glycoprotein ocular coherence tomography complement microcystic macular degeneration Müller cell astrocyte oligodendrocyte microglia optic nerve head lamina cribrosa lamina cribrosa cells scleral fibroblasts glial cells intraocular pressure rat anterior ischemic optic neuropathy model retinal ganglion cell death TBP associated factor 9 TP53 regulated inhibitor of apoptosis 1 transcriptome optic nerve epigenetics myelin regeneration oligodendrocytes atypical optic neuritis treatment typical optic neuritis MOG MS prevention retina transcription CNS repair oncomodulin myeloid cells glaucomatous optic neuropathy fibrosis miR-29 extracellular matrix optic nerve crush azithromycin NAION neural injury neural ischemia neural inflammation Leber’s hereditary optic neuropathy LHON whole exome sequencing nuclear modifier genes leber’s hereditary optic neuropathy mitochondrial disorder mitochondrial optic neuropathy hereditary optic neuropathy neuro-ophthalmology idebenone nonarteritic anterior ischemic optic neuropathy rodents gene expression models diabetes ischemic optic neuropathy pioglitazone HSF1 Klf4 Oct4 Sox2 Yamanaka factors optic nerve regeneration zebrafish oligodendrocyte precursor cells secondary degeneration oxidative stress DNA damage proliferation blood-brain barrier CNS injury optic nerve injury synaptamide A8 axonal degeneration neuronal survival visual evoked potential n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20230623_9783036575056_11 |