Stem Cells and Irradiation
The main difficulty of radiotherapy is to destroy cancer cells without depletion of healthy tissue. Stem cells and cancers are tightly interrelated. On one hand, radiosensitivity/radioressistance of cancer stem cells affects the radiocurability of tumors. On the other hand, radiosensitivity is respo...
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| Format: | Online |
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| Sprache: | Englisch |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Online-Zugang: | ONIX_20230623_9783036569017_23 |
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| description | The main difficulty of radiotherapy is to destroy cancer cells without depletion of healthy tissue. Stem cells and cancers are tightly interrelated. On one hand, radiosensitivity/radioressistance of cancer stem cells affects the radiocurability of tumors. On the other hand, radiosensitivity is responsible for the stem cell depletion of organs at risk exposed to irradiation. Efficient solide cancer destruction is limited by the preservation of organ homeostasis. For this reason, targeted irradiation is an effective cancer therapy, but damage inflicted to normal tissues surrounding the tumor may cause severe complications. The consequences of stem cell depletion of healthy tissue irradiated are acute and chronic radiation diseases. Research on the radiosensitivity of cancer stem cells and adult stem cells associated with tissue regeneration medicine will bring forth the solution for optimal radiocurability associated with long-term patients’ quality of life. |
| format | Online |
| id | doab-20.500.12854ir-100791 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1007912024-03-28T03:33:47Z Stem Cells and Irradiation Chapel, Alain human epidermis keratinocytes stem cells precursor cells low-dose γ irradiation regeneration dysplasia epithelial-to-mesenchymal transition (EMT) ZEB1 experimental radiotherapy radiobiology mesenchymal stem cells cell therapy exosome annexin A1 acute respiratory-distress syndrome COVID-19 local radiation injuries conditioned medium cell technologies X-ray radiation skin placenta Radiation stem/progenitor cells organoids radiation therapy radiation cystitis fibrosis treatment stem cells therapy macrophages mesenchymal stem cell radiation damage BCSC ALDH activity fractionated dose of γ radiation radioresistance ROS Nrf2 Keap1 miR200a epithelial–mesenchymal transition (EMT) colorectal cancer cancer-stem like cells SOX2 PI3K/AKT radiation-induced injury radiotherapy radiation mesenchymal stem cell extracellular vesicles micro vesicles paracrine effect adipose tissue derived stem cells n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences The main difficulty of radiotherapy is to destroy cancer cells without depletion of healthy tissue. Stem cells and cancers are tightly interrelated. On one hand, radiosensitivity/radioressistance of cancer stem cells affects the radiocurability of tumors. On the other hand, radiosensitivity is responsible for the stem cell depletion of organs at risk exposed to irradiation. Efficient solide cancer destruction is limited by the preservation of organ homeostasis. For this reason, targeted irradiation is an effective cancer therapy, but damage inflicted to normal tissues surrounding the tumor may cause severe complications. The consequences of stem cell depletion of healthy tissue irradiated are acute and chronic radiation diseases. Research on the radiosensitivity of cancer stem cells and adult stem cells associated with tissue regeneration medicine will bring forth the solution for optimal radiocurability associated with long-term patients’ quality of life. 2023-06-23T09:42:01Z 2023-06-23T09:42:01Z 2023 book ONIX_20230623_9783036569017_23 9783036569017 9783036569000 https://directory.doabooks.org/handle/20.500.12854/100791 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7253 https://mdpi.com/books/pdfview/book/7253 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-6900-0 10.3390/books978-3-0365-6900-0 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036569017 9783036569000 184 Basel open access |
| spellingShingle | human epidermis keratinocytes stem cells precursor cells low-dose γ irradiation regeneration dysplasia epithelial-to-mesenchymal transition (EMT) ZEB1 experimental radiotherapy radiobiology mesenchymal stem cells cell therapy exosome annexin A1 acute respiratory-distress syndrome COVID-19 local radiation injuries conditioned medium cell technologies X-ray radiation skin placenta Radiation stem/progenitor cells organoids radiation therapy radiation cystitis fibrosis treatment stem cells therapy macrophages mesenchymal stem cell radiation damage BCSC ALDH activity fractionated dose of γ radiation radioresistance ROS Nrf2 Keap1 miR200a epithelial–mesenchymal transition (EMT) colorectal cancer cancer-stem like cells SOX2 PI3K/AKT radiation-induced injury radiotherapy radiation mesenchymal stem cell extracellular vesicles micro vesicles paracrine effect adipose tissue derived stem cells n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Stem Cells and Irradiation |
| title | Stem Cells and Irradiation |
| title_full | Stem Cells and Irradiation |
| title_fullStr | Stem Cells and Irradiation |
| title_full_unstemmed | Stem Cells and Irradiation |
| title_short | Stem Cells and Irradiation |
| title_sort | stem cells and irradiation |
| topic | human epidermis keratinocytes stem cells precursor cells low-dose γ irradiation regeneration dysplasia epithelial-to-mesenchymal transition (EMT) ZEB1 experimental radiotherapy radiobiology mesenchymal stem cells cell therapy exosome annexin A1 acute respiratory-distress syndrome COVID-19 local radiation injuries conditioned medium cell technologies X-ray radiation skin placenta Radiation stem/progenitor cells organoids radiation therapy radiation cystitis fibrosis treatment stem cells therapy macrophages mesenchymal stem cell radiation damage BCSC ALDH activity fractionated dose of γ radiation radioresistance ROS Nrf2 Keap1 miR200a epithelial–mesenchymal transition (EMT) colorectal cancer cancer-stem like cells SOX2 PI3K/AKT radiation-induced injury radiotherapy radiation mesenchymal stem cell extracellular vesicles micro vesicles paracrine effect adipose tissue derived stem cells n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | human epidermis keratinocytes stem cells precursor cells low-dose γ irradiation regeneration dysplasia epithelial-to-mesenchymal transition (EMT) ZEB1 experimental radiotherapy radiobiology mesenchymal stem cells cell therapy exosome annexin A1 acute respiratory-distress syndrome COVID-19 local radiation injuries conditioned medium cell technologies X-ray radiation skin placenta Radiation stem/progenitor cells organoids radiation therapy radiation cystitis fibrosis treatment stem cells therapy macrophages mesenchymal stem cell radiation damage BCSC ALDH activity fractionated dose of γ radiation radioresistance ROS Nrf2 Keap1 miR200a epithelial–mesenchymal transition (EMT) colorectal cancer cancer-stem like cells SOX2 PI3K/AKT radiation-induced injury radiotherapy radiation mesenchymal stem cell extracellular vesicles micro vesicles paracrine effect adipose tissue derived stem cells n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20230623_9783036569017_23 |