Molecular and Clinical Advances in Understanding Early Embryo Development
This reprint considers a wide variety of topics concerning molecular and clinical advances in understanding early mammalian embryo development. The authors of various chapters of this book examine oocyte biology, preimplantation embryo development, blastocyst implantation in the uterus, and second c...
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| Ձևաչափ: | Online |
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| Լեզու: | անգլերեն |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Խորագրեր: | |
| Առցանց հասանելիություն: | ONIX_20230623_9783036574936_43 |
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Չկան պիտակներ, Եղեք առաջինը, ով նշում է այս գրառումը!
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| _version_ | 1869523127031037952 |
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| collection | Directory of Open Access Books |
| description | This reprint considers a wide variety of topics concerning molecular and clinical advances in understanding early mammalian embryo development. The authors of various chapters of this book examine oocyte biology, preimplantation embryo development, blastocyst implantation in the uterus, and second cellular lineage differentiation. In addition, epigenetic contributions to reproduction, which may occur throughout pregnancy and in resultant offspring, are also considered. Environmentally induced epigenetic changes in germ cells can render mammalian offspring less healthy, and these changes can be difficult to reverse. Included in these changes are those caused by assisted reproductive technologies (ARTs). It remains to be determined whether the healthiest preimplantation embryos develop in vitro in conditions that mimic the physiological environment in vivo or whether simpler conditions can also foster this development in vitro. In this regard, a number of advances as well as challenges in ART are considered by the authors of the chapters included in this book. |
| format | Online |
| id | doab-20.500.12854ir-100811 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1008112024-03-31T13:08:50Z Molecular and Clinical Advances in Understanding Early Embryo Development van Winkle, Lon J. oocyte amino acid transporters proline pipecolic acid in vitro fertilisation NANOG SOX17 bovine preimplantation development MEK second lineage differentiation sequence domain segregation epigenetic modification ZGA and implantation MacERV6-LTR1a primitive endoderm trophectoderm epiblast cynomolgus monkey embryos ESRRB porcine embryo culture in vitro maturation in vitro fertilization amino acid transport amino acid metabolism embryo development epigenetic modifications offspring maternal obesity childhood obesity lifestyle intervention cardiometabolic health programming follow-up embryo embryogenesis oogenesis fertility mitochondria mitochondrial DNA (mtDNA) mitochondrial score mitochondrial replacement therapy (MRT) autologous mitochondrial transfer germinal vesicle human electron microscopy assisted reproductive technologies (ARTs) decidualization recurrent spontaneous abortion long noncoding RNA epigenetics H3K27 methylation miR-155 CRISPR/Cas9 extracellular vesicles ROCK inhibitor preimplantation embryo diabetes DOHaD rabbit amino acid transporter Slc6a19 B0AT1 mouse n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBG Medical equipment and techniques This reprint considers a wide variety of topics concerning molecular and clinical advances in understanding early mammalian embryo development. The authors of various chapters of this book examine oocyte biology, preimplantation embryo development, blastocyst implantation in the uterus, and second cellular lineage differentiation. In addition, epigenetic contributions to reproduction, which may occur throughout pregnancy and in resultant offspring, are also considered. Environmentally induced epigenetic changes in germ cells can render mammalian offspring less healthy, and these changes can be difficult to reverse. Included in these changes are those caused by assisted reproductive technologies (ARTs). It remains to be determined whether the healthiest preimplantation embryos develop in vitro in conditions that mimic the physiological environment in vivo or whether simpler conditions can also foster this development in vitro. In this regard, a number of advances as well as challenges in ART are considered by the authors of the chapters included in this book. 2023-06-23T09:44:36Z 2023-06-23T09:44:36Z 2023 book ONIX_20230623_9783036574936_43 9783036574936 9783036574929 https://directory.doabooks.org/handle/20.500.12854/100811 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7274 https://mdpi.com/books/pdfview/book/7274 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7492-9 10.3390/books978-3-0365-7492-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036574936 9783036574929 256 Basel open access |
| spellingShingle | oocyte amino acid transporters proline pipecolic acid in vitro fertilisation NANOG SOX17 bovine preimplantation development MEK second lineage differentiation sequence domain segregation epigenetic modification ZGA and implantation MacERV6-LTR1a primitive endoderm trophectoderm epiblast cynomolgus monkey embryos ESRRB porcine embryo culture in vitro maturation in vitro fertilization amino acid transport amino acid metabolism embryo development epigenetic modifications offspring maternal obesity childhood obesity lifestyle intervention cardiometabolic health programming follow-up embryo embryogenesis oogenesis fertility mitochondria mitochondrial DNA (mtDNA) mitochondrial score mitochondrial replacement therapy (MRT) autologous mitochondrial transfer germinal vesicle human electron microscopy assisted reproductive technologies (ARTs) decidualization recurrent spontaneous abortion long noncoding RNA epigenetics H3K27 methylation miR-155 CRISPR/Cas9 extracellular vesicles ROCK inhibitor preimplantation embryo diabetes DOHaD rabbit amino acid transporter Slc6a19 B0AT1 mouse n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBG Medical equipment and techniques Molecular and Clinical Advances in Understanding Early Embryo Development |
| title | Molecular and Clinical Advances in Understanding Early Embryo Development |
| title_full | Molecular and Clinical Advances in Understanding Early Embryo Development |
| title_fullStr | Molecular and Clinical Advances in Understanding Early Embryo Development |
| title_full_unstemmed | Molecular and Clinical Advances in Understanding Early Embryo Development |
| title_short | Molecular and Clinical Advances in Understanding Early Embryo Development |
| title_sort | molecular and clinical advances in understanding early embryo development |
| topic | oocyte amino acid transporters proline pipecolic acid in vitro fertilisation NANOG SOX17 bovine preimplantation development MEK second lineage differentiation sequence domain segregation epigenetic modification ZGA and implantation MacERV6-LTR1a primitive endoderm trophectoderm epiblast cynomolgus monkey embryos ESRRB porcine embryo culture in vitro maturation in vitro fertilization amino acid transport amino acid metabolism embryo development epigenetic modifications offspring maternal obesity childhood obesity lifestyle intervention cardiometabolic health programming follow-up embryo embryogenesis oogenesis fertility mitochondria mitochondrial DNA (mtDNA) mitochondrial score mitochondrial replacement therapy (MRT) autologous mitochondrial transfer germinal vesicle human electron microscopy assisted reproductive technologies (ARTs) decidualization recurrent spontaneous abortion long noncoding RNA epigenetics H3K27 methylation miR-155 CRISPR/Cas9 extracellular vesicles ROCK inhibitor preimplantation embryo diabetes DOHaD rabbit amino acid transporter Slc6a19 B0AT1 mouse n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBG Medical equipment and techniques |
| topic_facet | oocyte amino acid transporters proline pipecolic acid in vitro fertilisation NANOG SOX17 bovine preimplantation development MEK second lineage differentiation sequence domain segregation epigenetic modification ZGA and implantation MacERV6-LTR1a primitive endoderm trophectoderm epiblast cynomolgus monkey embryos ESRRB porcine embryo culture in vitro maturation in vitro fertilization amino acid transport amino acid metabolism embryo development epigenetic modifications offspring maternal obesity childhood obesity lifestyle intervention cardiometabolic health programming follow-up embryo embryogenesis oogenesis fertility mitochondria mitochondrial DNA (mtDNA) mitochondrial score mitochondrial replacement therapy (MRT) autologous mitochondrial transfer germinal vesicle human electron microscopy assisted reproductive technologies (ARTs) decidualization recurrent spontaneous abortion long noncoding RNA epigenetics H3K27 methylation miR-155 CRISPR/Cas9 extracellular vesicles ROCK inhibitor preimplantation embryo diabetes DOHaD rabbit amino acid transporter Slc6a19 B0AT1 mouse n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBG Medical equipment and techniques |
| url | ONIX_20230623_9783036574936_43 |