Purinergic Signaling in Neuroinflammation
It is currently apparent that extracellular ATP's physiological effect is mediated by its interaction with specific purinergic receptors. All purinergic receptors are divided into P1-purinoreceptors and P2-purinoreceptors. Each of the subtypes is divided into a number of families. For instance, P2 r...
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| বিন্যাস: | Online |
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| ভাষা: | ইংরেজি |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | ONIX_20230623_9783036576879_81 |
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| collection | Directory of Open Access Books |
| description | It is currently apparent that extracellular ATP's physiological effect is mediated by its interaction with specific purinergic receptors. All purinergic receptors are divided into P1-purinoreceptors and P2-purinoreceptors. Each of the subtypes is divided into a number of families. For instance, P2 receptors are divided into P2X and P2Y receptors according to the mechanism by which their effect is realized: P2Y are G-protein-coupled receptors, while P2X receptors are ligand-operated ion channels. P2X receptors are important molecular therapeutic targets, the malfunctioning of which leads to severe complications in the physiology of humans and animals and causes dangerous diseases. The search for compounds that can modulate the function of purinergic receptors can lead to the creation of new drugs that are effective in central and peripheral nervous system and immune system disease treatment, including neuroinflammation, hypoxia/ischemia, epilepsy and neuropathic pain. In this Special Issue, we wish to offer a platform for high-quality publications on the latest advances in the identification of P2X/Y- and P1-receptor blockers, functions and regulation by them; the characterization of these receptor signaling networks and crosstalk; mechanisms underlying the role of purinoceptors in neurodegenerative illnesses as well as chronic neuronal changes following acute noxious damage and therapeutic opportunities associated with regulation of purinergic receptor activity. |
| format | Online |
| id | doab-20.500.12854ir-100849 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1008492024-03-28T03:33:45Z Purinergic Signaling in Neuroinflammation Aminin, Dmitry Illes, Peter adenosine receptors adipogenesis osteogenesis adipose tissue bone marrow obesity neonatal seizures development ATP purinergic signalling P2X7 receptor endometriosis adenosine P2Y P2X ectonucleotidases pain inflammation endometrium CD73 CD39 P2Y2 receptor P2X4 receptor canine dog DH82 macrophage neuroinflammation antinociception cerebral ischemia oxygen-glucose deprivation A2B receptors oligodendrocyte differentiation demyelination retina purinergic modulation glycinergic neurotransmission microglia neurodegeneration glycine transporters guanosine stroke neuroprotection purinergic signaling purinergic receptors autoimmune disease astroglia G protein-coupled receptor 17 (GPR17) neurite outgrowth montelukast NG2 ex vivo organotypic brain slice co-culture neurodegeneration and neuroregeneration n/a macrophages P2X7R pore formation inflammasome activation inflammatory diseases gallic acid visceral pain depression hippocampus spinal cord dorsal root ganglion thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences It is currently apparent that extracellular ATP's physiological effect is mediated by its interaction with specific purinergic receptors. All purinergic receptors are divided into P1-purinoreceptors and P2-purinoreceptors. Each of the subtypes is divided into a number of families. For instance, P2 receptors are divided into P2X and P2Y receptors according to the mechanism by which their effect is realized: P2Y are G-protein-coupled receptors, while P2X receptors are ligand-operated ion channels. P2X receptors are important molecular therapeutic targets, the malfunctioning of which leads to severe complications in the physiology of humans and animals and causes dangerous diseases. The search for compounds that can modulate the function of purinergic receptors can lead to the creation of new drugs that are effective in central and peripheral nervous system and immune system disease treatment, including neuroinflammation, hypoxia/ischemia, epilepsy and neuropathic pain. In this Special Issue, we wish to offer a platform for high-quality publications on the latest advances in the identification of P2X/Y- and P1-receptor blockers, functions and regulation by them; the characterization of these receptor signaling networks and crosstalk; mechanisms underlying the role of purinoceptors in neurodegenerative illnesses as well as chronic neuronal changes following acute noxious damage and therapeutic opportunities associated with regulation of purinergic receptor activity. 2023-06-23T09:47:41Z 2023-06-23T09:47:41Z 2023 book ONIX_20230623_9783036576879_81 9783036576879 9783036576862 https://directory.doabooks.org/handle/20.500.12854/100849 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7312 https://mdpi.com/books/pdfview/book/7312 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7686-2 10.3390/books978-3-0365-7686-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036576879 9783036576862 276 Basel open access |
| spellingShingle | adenosine receptors adipogenesis osteogenesis adipose tissue bone marrow obesity neonatal seizures development ATP purinergic signalling P2X7 receptor endometriosis adenosine P2Y P2X ectonucleotidases pain inflammation endometrium CD73 CD39 P2Y2 receptor P2X4 receptor canine dog DH82 macrophage neuroinflammation antinociception cerebral ischemia oxygen-glucose deprivation A2B receptors oligodendrocyte differentiation demyelination retina purinergic modulation glycinergic neurotransmission microglia neurodegeneration glycine transporters guanosine stroke neuroprotection purinergic signaling purinergic receptors autoimmune disease astroglia G protein-coupled receptor 17 (GPR17) neurite outgrowth montelukast NG2 ex vivo organotypic brain slice co-culture neurodegeneration and neuroregeneration n/a macrophages P2X7R pore formation inflammasome activation inflammatory diseases gallic acid visceral pain depression hippocampus spinal cord dorsal root ganglion thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Purinergic Signaling in Neuroinflammation |
| title | Purinergic Signaling in Neuroinflammation |
| title_full | Purinergic Signaling in Neuroinflammation |
| title_fullStr | Purinergic Signaling in Neuroinflammation |
| title_full_unstemmed | Purinergic Signaling in Neuroinflammation |
| title_short | Purinergic Signaling in Neuroinflammation |
| title_sort | purinergic signaling in neuroinflammation |
| topic | adenosine receptors adipogenesis osteogenesis adipose tissue bone marrow obesity neonatal seizures development ATP purinergic signalling P2X7 receptor endometriosis adenosine P2Y P2X ectonucleotidases pain inflammation endometrium CD73 CD39 P2Y2 receptor P2X4 receptor canine dog DH82 macrophage neuroinflammation antinociception cerebral ischemia oxygen-glucose deprivation A2B receptors oligodendrocyte differentiation demyelination retina purinergic modulation glycinergic neurotransmission microglia neurodegeneration glycine transporters guanosine stroke neuroprotection purinergic signaling purinergic receptors autoimmune disease astroglia G protein-coupled receptor 17 (GPR17) neurite outgrowth montelukast NG2 ex vivo organotypic brain slice co-culture neurodegeneration and neuroregeneration n/a macrophages P2X7R pore formation inflammasome activation inflammatory diseases gallic acid visceral pain depression hippocampus spinal cord dorsal root ganglion thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | adenosine receptors adipogenesis osteogenesis adipose tissue bone marrow obesity neonatal seizures development ATP purinergic signalling P2X7 receptor endometriosis adenosine P2Y P2X ectonucleotidases pain inflammation endometrium CD73 CD39 P2Y2 receptor P2X4 receptor canine dog DH82 macrophage neuroinflammation antinociception cerebral ischemia oxygen-glucose deprivation A2B receptors oligodendrocyte differentiation demyelination retina purinergic modulation glycinergic neurotransmission microglia neurodegeneration glycine transporters guanosine stroke neuroprotection purinergic signaling purinergic receptors autoimmune disease astroglia G protein-coupled receptor 17 (GPR17) neurite outgrowth montelukast NG2 ex vivo organotypic brain slice co-culture neurodegeneration and neuroregeneration n/a macrophages P2X7R pore formation inflammasome activation inflammatory diseases gallic acid visceral pain depression hippocampus spinal cord dorsal root ganglion thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20230623_9783036576879_81 |