Genetics and Epigenetics in Complex Diseases
Many of the most common diseases are influenced by a combination of multiple factors, which include environmental effectors as well as genetic and epigenetic variations. Therefore, these diseases are grouped under the term “complex” diseases because, from the point of view of genetics, they cannot b...
محفوظ في:
| التنسيق: | Online |
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| اللغة: | الإنجليزية |
| منشور في: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| الموضوعات: | |
| الوصول للمادة أونلاين: | ONIX_20230714_9783036578576_4 |
| الوسوم: |
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| _version_ | 1869521643361009664 |
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| collection | Directory of Open Access Books |
| description | Many of the most common diseases are influenced by a combination of multiple factors, which include environmental effectors as well as genetic and epigenetic variations. Therefore, these diseases are grouped under the term “complex” diseases because, from the point of view of genetics, they cannot be explained by simple Mendelian inheritance. The aim of this special issue was to identify genetic and epigenetic factors involved in such diseases in order to improve not only the knowledge of risk factors for those diseases, which could be of help for prevention, but also the understanding and characterization of each disease and to optimize and personalize the treatment. |
| format | Online |
| id | doab-20.500.12854ir-101305 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1013052024-03-28T03:31:09Z Genetics and Epigenetics in Complex Diseases Lopez-Lopez, Elixabet chromatin remodeling circular RNA DNA methylation histone modification non-coding RNA oncogenes tumor suppressor genes tumor virus chronic lymphocytic leukemia CLL SF3B1 mutation NOTCH IKAROS syncope vasovagal syncope genetics complex disorders susceptibility twin studies family studies candidate gene association studies genome-wide studies acute myeloid leukemia pediatric trio sequencing germline cancer predisposition POT1 shelterin complex psoriasis psoriatic arthritis NF-κB comorbidities genetic architecture SKP1 CUL1 RBX1 SKP2 FBXW7 FBXO5 SCF complex genome instability chromosome instability cancer VDBP vitamin D binding protein rs7041 rs4588 bone density diabetes obesity COPD pulmonary tuberculosis SNP MD PD CD33 Alzheimer’s disease sialic acid phagocytosis KLF14 body shape indices metabolic traits differential effect genetic variants resistin soluble suppression of tumorigenicity 2 weighted genetic risk score Taiwan Biobank coronary artery disease all-cause mortality major adverse cardiac events acute lymphoblastic leukemia RAD21 cohesin complex n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) Many of the most common diseases are influenced by a combination of multiple factors, which include environmental effectors as well as genetic and epigenetic variations. Therefore, these diseases are grouped under the term “complex” diseases because, from the point of view of genetics, they cannot be explained by simple Mendelian inheritance. The aim of this special issue was to identify genetic and epigenetic factors involved in such diseases in order to improve not only the knowledge of risk factors for those diseases, which could be of help for prevention, but also the understanding and characterization of each disease and to optimize and personalize the treatment. 2023-07-14T14:22:56Z 2023-07-14T14:22:56Z 2023 book ONIX_20230714_9783036578576_4 9783036578576 9783036578569 https://directory.doabooks.org/handle/20.500.12854/101305 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7398 https://mdpi.com/books/pdfview/book/7398 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7856-9 10.3390/books978-3-0365-7856-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036578576 9783036578569 238 Basel open access |
| spellingShingle | chromatin remodeling circular RNA DNA methylation histone modification non-coding RNA oncogenes tumor suppressor genes tumor virus chronic lymphocytic leukemia CLL SF3B1 mutation NOTCH IKAROS syncope vasovagal syncope genetics complex disorders susceptibility twin studies family studies candidate gene association studies genome-wide studies acute myeloid leukemia pediatric trio sequencing germline cancer predisposition POT1 shelterin complex psoriasis psoriatic arthritis NF-κB comorbidities genetic architecture SKP1 CUL1 RBX1 SKP2 FBXW7 FBXO5 SCF complex genome instability chromosome instability cancer VDBP vitamin D binding protein rs7041 rs4588 bone density diabetes obesity COPD pulmonary tuberculosis SNP MD PD CD33 Alzheimer’s disease sialic acid phagocytosis KLF14 body shape indices metabolic traits differential effect genetic variants resistin soluble suppression of tumorigenicity 2 weighted genetic risk score Taiwan Biobank coronary artery disease all-cause mortality major adverse cardiac events acute lymphoblastic leukemia RAD21 cohesin complex n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) Genetics and Epigenetics in Complex Diseases |
| title | Genetics and Epigenetics in Complex Diseases |
| title_full | Genetics and Epigenetics in Complex Diseases |
| title_fullStr | Genetics and Epigenetics in Complex Diseases |
| title_full_unstemmed | Genetics and Epigenetics in Complex Diseases |
| title_short | Genetics and Epigenetics in Complex Diseases |
| title_sort | genetics and epigenetics in complex diseases |
| topic | chromatin remodeling circular RNA DNA methylation histone modification non-coding RNA oncogenes tumor suppressor genes tumor virus chronic lymphocytic leukemia CLL SF3B1 mutation NOTCH IKAROS syncope vasovagal syncope genetics complex disorders susceptibility twin studies family studies candidate gene association studies genome-wide studies acute myeloid leukemia pediatric trio sequencing germline cancer predisposition POT1 shelterin complex psoriasis psoriatic arthritis NF-κB comorbidities genetic architecture SKP1 CUL1 RBX1 SKP2 FBXW7 FBXO5 SCF complex genome instability chromosome instability cancer VDBP vitamin D binding protein rs7041 rs4588 bone density diabetes obesity COPD pulmonary tuberculosis SNP MD PD CD33 Alzheimer’s disease sialic acid phagocytosis KLF14 body shape indices metabolic traits differential effect genetic variants resistin soluble suppression of tumorigenicity 2 weighted genetic risk score Taiwan Biobank coronary artery disease all-cause mortality major adverse cardiac events acute lymphoblastic leukemia RAD21 cohesin complex n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) |
| topic_facet | chromatin remodeling circular RNA DNA methylation histone modification non-coding RNA oncogenes tumor suppressor genes tumor virus chronic lymphocytic leukemia CLL SF3B1 mutation NOTCH IKAROS syncope vasovagal syncope genetics complex disorders susceptibility twin studies family studies candidate gene association studies genome-wide studies acute myeloid leukemia pediatric trio sequencing germline cancer predisposition POT1 shelterin complex psoriasis psoriatic arthritis NF-κB comorbidities genetic architecture SKP1 CUL1 RBX1 SKP2 FBXW7 FBXO5 SCF complex genome instability chromosome instability cancer VDBP vitamin D binding protein rs7041 rs4588 bone density diabetes obesity COPD pulmonary tuberculosis SNP MD PD CD33 Alzheimer’s disease sialic acid phagocytosis KLF14 body shape indices metabolic traits differential effect genetic variants resistin soluble suppression of tumorigenicity 2 weighted genetic risk score Taiwan Biobank coronary artery disease all-cause mortality major adverse cardiac events acute lymphoblastic leukemia RAD21 cohesin complex n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) |
| url | ONIX_20230714_9783036578576_4 |