Pathogenesis and Novel Therapeutics in Asthma
Asthma is a prevalent chronic inflammatory disease of the airways with complex etiology and mechanistic pathways and variable clinical presentation. Such heterogeneity renders the search for targeted therapies difficult. Currently, the best-known disease phenotype with tailored biological treatment...
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| Формат: | Online |
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| Язык: | английский |
| Опубликовано: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Предметы: | |
| Online-ссылка: | ONIX_20230714_9783036578422_21 |
| Метки: |
Нет меток, Требуется 1-ая метка записи!
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| _version_ | 1869527226222903296 |
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| collection | Directory of Open Access Books |
| description | Asthma is a prevalent chronic inflammatory disease of the airways with complex etiology and mechanistic pathways and variable clinical presentation. Such heterogeneity renders the search for targeted therapies difficult. Currently, the best-known disease phenotype with tailored biological treatment is eosinophilic asthma; however, even in some of these patients, anti-IL5 treatment is ineffective. Furthermore, about a quarter of patients, especially those with a severe phenotype, develop progressive and irreversible airway obstruction, leading to persistent symptoms despite optimized treatment. Therefore, new therapeutic approaches are still needed, particularly in severe asthma. The Special Issue presents asthma research focusing on modern personalized therapeutic approaches. Particular interest is directed to novel asthma biomarkers, including molecular and epigenetic ones, shining new light on pathogenesis, phenotyping, and customized therapy in various airway inflammatory patterns of the disease. In addition, research articles on airway epithelial cell dysfunction, airway remodeling, and the overlap between asthma and chronic obstructive pulmonary disease are welcomed. Stanislawa Bazan-Socha (Guest Editors) |
| format | Online |
| id | doab-20.500.12854ir-101322 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1013222024-03-31T13:09:52Z Pathogenesis and Novel Therapeutics in Asthma Bazan-Socha, Stanislawa bronchial epithelial cells extracellular vesicles miRNAs airway epithelium asthma cellular compartmentalization allergic rhinitis allergen immunotherapy bronchial asthma component-resolved diagnosis sublingual immunotherapy fungal sensitization IL-17A Candida albicans mediation effect oxidative stress CBA assay airway remodeling severe asthma bronchial fibroblasts fibrosis Bcl10 NF-κB pathway cytokines efficacy investigational Phase I Phase II RCT allergy eosinophils immune health natural therapeutics prostacyclin allergic inflammation proinflammatory anti-inflammatory BLT2 G-CSF 12-LO neutrophil airway inflammation n/a miRNA children serum exhaled breath condensate diagnosis exacerbation biomarkers factors thema EDItEUR::M Medicine and Nursing Asthma is a prevalent chronic inflammatory disease of the airways with complex etiology and mechanistic pathways and variable clinical presentation. Such heterogeneity renders the search for targeted therapies difficult. Currently, the best-known disease phenotype with tailored biological treatment is eosinophilic asthma; however, even in some of these patients, anti-IL5 treatment is ineffective. Furthermore, about a quarter of patients, especially those with a severe phenotype, develop progressive and irreversible airway obstruction, leading to persistent symptoms despite optimized treatment. Therefore, new therapeutic approaches are still needed, particularly in severe asthma. The Special Issue presents asthma research focusing on modern personalized therapeutic approaches. Particular interest is directed to novel asthma biomarkers, including molecular and epigenetic ones, shining new light on pathogenesis, phenotyping, and customized therapy in various airway inflammatory patterns of the disease. In addition, research articles on airway epithelial cell dysfunction, airway remodeling, and the overlap between asthma and chronic obstructive pulmonary disease are welcomed. Stanislawa Bazan-Socha (Guest Editors) 2023-07-14T14:24:08Z 2023-07-14T14:24:08Z 2023 book ONIX_20230714_9783036578422_21 9783036578422 9783036578439 https://directory.doabooks.org/handle/20.500.12854/101322 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7416 https://mdpi.com/books/pdfview/book/7416 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7843-9 10.3390/books978-3-0365-7843-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036578422 9783036578439 168 Basel open access |
| spellingShingle | bronchial epithelial cells extracellular vesicles miRNAs airway epithelium asthma cellular compartmentalization allergic rhinitis allergen immunotherapy bronchial asthma component-resolved diagnosis sublingual immunotherapy fungal sensitization IL-17A Candida albicans mediation effect oxidative stress CBA assay airway remodeling severe asthma bronchial fibroblasts fibrosis Bcl10 NF-κB pathway cytokines efficacy investigational Phase I Phase II RCT allergy eosinophils immune health natural therapeutics prostacyclin allergic inflammation proinflammatory anti-inflammatory BLT2 G-CSF 12-LO neutrophil airway inflammation n/a miRNA children serum exhaled breath condensate diagnosis exacerbation biomarkers factors thema EDItEUR::M Medicine and Nursing Pathogenesis and Novel Therapeutics in Asthma |
| title | Pathogenesis and Novel Therapeutics in Asthma |
| title_full | Pathogenesis and Novel Therapeutics in Asthma |
| title_fullStr | Pathogenesis and Novel Therapeutics in Asthma |
| title_full_unstemmed | Pathogenesis and Novel Therapeutics in Asthma |
| title_short | Pathogenesis and Novel Therapeutics in Asthma |
| title_sort | pathogenesis and novel therapeutics in asthma |
| topic | bronchial epithelial cells extracellular vesicles miRNAs airway epithelium asthma cellular compartmentalization allergic rhinitis allergen immunotherapy bronchial asthma component-resolved diagnosis sublingual immunotherapy fungal sensitization IL-17A Candida albicans mediation effect oxidative stress CBA assay airway remodeling severe asthma bronchial fibroblasts fibrosis Bcl10 NF-κB pathway cytokines efficacy investigational Phase I Phase II RCT allergy eosinophils immune health natural therapeutics prostacyclin allergic inflammation proinflammatory anti-inflammatory BLT2 G-CSF 12-LO neutrophil airway inflammation n/a miRNA children serum exhaled breath condensate diagnosis exacerbation biomarkers factors thema EDItEUR::M Medicine and Nursing |
| topic_facet | bronchial epithelial cells extracellular vesicles miRNAs airway epithelium asthma cellular compartmentalization allergic rhinitis allergen immunotherapy bronchial asthma component-resolved diagnosis sublingual immunotherapy fungal sensitization IL-17A Candida albicans mediation effect oxidative stress CBA assay airway remodeling severe asthma bronchial fibroblasts fibrosis Bcl10 NF-κB pathway cytokines efficacy investigational Phase I Phase II RCT allergy eosinophils immune health natural therapeutics prostacyclin allergic inflammation proinflammatory anti-inflammatory BLT2 G-CSF 12-LO neutrophil airway inflammation n/a miRNA children serum exhaled breath condensate diagnosis exacerbation biomarkers factors thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20230714_9783036578422_21 |