Therapeutic Potential for Cannabis and Cannabinoids
Cannabis has a history of medical use dating back millennia; however, the use of cannabis for medicinal purposes fell out of favor in the middle of the last century. There is currently a renewed interest in the potential medicinal value of this plant, as well as individual compounds produced by Cann...
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| Формат: | Online |
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| Язык: | английский |
| Опубликовано: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Предметы: | |
| Online-ссылка: | ONIX_20230714_9783036575827_25 |
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| _version_ | 1869521670615597056 |
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| collection | Directory of Open Access Books |
| description | Cannabis has a history of medical use dating back millennia; however, the use of cannabis for medicinal purposes fell out of favor in the middle of the last century. There is currently a renewed interest in the potential medicinal value of this plant, as well as individual compounds produced by Cannabis (as well as synthetic analogs). Currently, nearly 50 countries permit the medical use of cannabis, and over a dozen other countries have legalized cannabis-based products (CBD, Sativex, Dronabinol, etc.) for medical use. While there exists a plethora of anecdotal reports indicating that cannabis can treat a variety of diseases, there is a limited amount of strong, evidence-based scientific data to support these claims. This Special Edition of Biomedicines, “Therapeutic Potential for Cannabis and Cannabinoids”, was dedicated to providing evidence for the medicinal value of cannabis to treat human illness and disease. Topics included, but were not limited to, preclinical animal models examining the efficacy of cannabis and cannabinoid derivatives on pain, anxiety, cancer, and other diseases; and cell and molecular models of cannabinoid pharmacokinetics, drug–drug interactions, and disease treatment. These studies are of great importance not only for progressing the cannabis field, but also for validating the use of cannabis and cannabinoids as therapeutics. |
| format | Online |
| id | doab-20.500.12854ir-101326 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1013262024-03-30T23:22:54Z Therapeutic Potential for Cannabis and Cannabinoids Raup-Konsavage, Wesley M. anti-microbial activity anti-biofilm activity Cannabis sativa L. endocannabinoids gut microbiota pathogens phytocannabinoids synovial fibroblast rheumatoid arthritis cannabis tetrahydrocannabinol cytokines calcium PBMC cannabinoid receptors TRPA1 2-hydroxy oleic acid anandamide anti Bcl2 endocannabinoid system membrane lipid therapy neuroblastoma N-arachidonoylethanolamine cortisol chronic pain injury autism spectrum disorder cannabinoids cannabidiol clinical trials randomized controlled sleep child psychiatry developmental disorders rat post-traumatic stress disorder (PTSD) URB597 mGluR5 CB1 receptor fatty acid amide hydrolase (FAAH) β-catenin cannabinoid immune macrophage elderly inflammatory bowel disease D9 tetrahydrocannabinol nitric oxide epilepsy animal model cognitive dysfunction zebrafish ∆9-tetrahydrocannabinol THC CBD prefrontal cortex striatum BDNF aging age-related diseases neuropathic pain anxiety inhalation HRQoL phytochemistry terpenes synergy entourage effect biosynthesis HIV cannabidiol (CBD) tetrahydrocannabinol (THC) chronic liver diseases quality of life pilot clinical trial MMP-2 MMP-9 VSMC H9c2 cells glucose cell proliferation apoptosis cardiovascular disease FAAH inhibitors MGL inhibitors neonatal brain injury hypoxia–ischemia neuroprotection neurogenesis inflammation bile acids transcriptomics estrogen deficiency ovariectomized mice postmenopause gut organoids ghrelin GHSR signaling late adolescence medical cannabis polypharmacy n/a thema EDItEUR::M Medicine and Nursing Cannabis has a history of medical use dating back millennia; however, the use of cannabis for medicinal purposes fell out of favor in the middle of the last century. There is currently a renewed interest in the potential medicinal value of this plant, as well as individual compounds produced by Cannabis (as well as synthetic analogs). Currently, nearly 50 countries permit the medical use of cannabis, and over a dozen other countries have legalized cannabis-based products (CBD, Sativex, Dronabinol, etc.) for medical use. While there exists a plethora of anecdotal reports indicating that cannabis can treat a variety of diseases, there is a limited amount of strong, evidence-based scientific data to support these claims. This Special Edition of Biomedicines, “Therapeutic Potential for Cannabis and Cannabinoids”, was dedicated to providing evidence for the medicinal value of cannabis to treat human illness and disease. Topics included, but were not limited to, preclinical animal models examining the efficacy of cannabis and cannabinoid derivatives on pain, anxiety, cancer, and other diseases; and cell and molecular models of cannabinoid pharmacokinetics, drug–drug interactions, and disease treatment. These studies are of great importance not only for progressing the cannabis field, but also for validating the use of cannabis and cannabinoids as therapeutics. 2023-07-14T14:24:24Z 2023-07-14T14:24:24Z 2023 book ONIX_20230714_9783036575827_25 9783036575827 9783036575834 https://directory.doabooks.org/handle/20.500.12854/101326 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7420 https://mdpi.com/books/pdfview/book/7420 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7583-4 10.3390/books978-3-0365-7583-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036575827 9783036575834 424 Basel open access |
| spellingShingle | anti-microbial activity anti-biofilm activity Cannabis sativa L. endocannabinoids gut microbiota pathogens phytocannabinoids synovial fibroblast rheumatoid arthritis cannabis tetrahydrocannabinol cytokines calcium PBMC cannabinoid receptors TRPA1 2-hydroxy oleic acid anandamide anti Bcl2 endocannabinoid system membrane lipid therapy neuroblastoma N-arachidonoylethanolamine cortisol chronic pain injury autism spectrum disorder cannabinoids cannabidiol clinical trials randomized controlled sleep child psychiatry developmental disorders rat post-traumatic stress disorder (PTSD) URB597 mGluR5 CB1 receptor fatty acid amide hydrolase (FAAH) β-catenin cannabinoid immune macrophage elderly inflammatory bowel disease D9 tetrahydrocannabinol nitric oxide epilepsy animal model cognitive dysfunction zebrafish ∆9-tetrahydrocannabinol THC CBD prefrontal cortex striatum BDNF aging age-related diseases neuropathic pain anxiety inhalation HRQoL phytochemistry terpenes synergy entourage effect biosynthesis HIV cannabidiol (CBD) tetrahydrocannabinol (THC) chronic liver diseases quality of life pilot clinical trial MMP-2 MMP-9 VSMC H9c2 cells glucose cell proliferation apoptosis cardiovascular disease FAAH inhibitors MGL inhibitors neonatal brain injury hypoxia–ischemia neuroprotection neurogenesis inflammation bile acids transcriptomics estrogen deficiency ovariectomized mice postmenopause gut organoids ghrelin GHSR signaling late adolescence medical cannabis polypharmacy n/a thema EDItEUR::M Medicine and Nursing Therapeutic Potential for Cannabis and Cannabinoids |
| title | Therapeutic Potential for Cannabis and Cannabinoids |
| title_full | Therapeutic Potential for Cannabis and Cannabinoids |
| title_fullStr | Therapeutic Potential for Cannabis and Cannabinoids |
| title_full_unstemmed | Therapeutic Potential for Cannabis and Cannabinoids |
| title_short | Therapeutic Potential for Cannabis and Cannabinoids |
| title_sort | therapeutic potential for cannabis and cannabinoids |
| topic | anti-microbial activity anti-biofilm activity Cannabis sativa L. endocannabinoids gut microbiota pathogens phytocannabinoids synovial fibroblast rheumatoid arthritis cannabis tetrahydrocannabinol cytokines calcium PBMC cannabinoid receptors TRPA1 2-hydroxy oleic acid anandamide anti Bcl2 endocannabinoid system membrane lipid therapy neuroblastoma N-arachidonoylethanolamine cortisol chronic pain injury autism spectrum disorder cannabinoids cannabidiol clinical trials randomized controlled sleep child psychiatry developmental disorders rat post-traumatic stress disorder (PTSD) URB597 mGluR5 CB1 receptor fatty acid amide hydrolase (FAAH) β-catenin cannabinoid immune macrophage elderly inflammatory bowel disease D9 tetrahydrocannabinol nitric oxide epilepsy animal model cognitive dysfunction zebrafish ∆9-tetrahydrocannabinol THC CBD prefrontal cortex striatum BDNF aging age-related diseases neuropathic pain anxiety inhalation HRQoL phytochemistry terpenes synergy entourage effect biosynthesis HIV cannabidiol (CBD) tetrahydrocannabinol (THC) chronic liver diseases quality of life pilot clinical trial MMP-2 MMP-9 VSMC H9c2 cells glucose cell proliferation apoptosis cardiovascular disease FAAH inhibitors MGL inhibitors neonatal brain injury hypoxia–ischemia neuroprotection neurogenesis inflammation bile acids transcriptomics estrogen deficiency ovariectomized mice postmenopause gut organoids ghrelin GHSR signaling late adolescence medical cannabis polypharmacy n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | anti-microbial activity anti-biofilm activity Cannabis sativa L. endocannabinoids gut microbiota pathogens phytocannabinoids synovial fibroblast rheumatoid arthritis cannabis tetrahydrocannabinol cytokines calcium PBMC cannabinoid receptors TRPA1 2-hydroxy oleic acid anandamide anti Bcl2 endocannabinoid system membrane lipid therapy neuroblastoma N-arachidonoylethanolamine cortisol chronic pain injury autism spectrum disorder cannabinoids cannabidiol clinical trials randomized controlled sleep child psychiatry developmental disorders rat post-traumatic stress disorder (PTSD) URB597 mGluR5 CB1 receptor fatty acid amide hydrolase (FAAH) β-catenin cannabinoid immune macrophage elderly inflammatory bowel disease D9 tetrahydrocannabinol nitric oxide epilepsy animal model cognitive dysfunction zebrafish ∆9-tetrahydrocannabinol THC CBD prefrontal cortex striatum BDNF aging age-related diseases neuropathic pain anxiety inhalation HRQoL phytochemistry terpenes synergy entourage effect biosynthesis HIV cannabidiol (CBD) tetrahydrocannabinol (THC) chronic liver diseases quality of life pilot clinical trial MMP-2 MMP-9 VSMC H9c2 cells glucose cell proliferation apoptosis cardiovascular disease FAAH inhibitors MGL inhibitors neonatal brain injury hypoxia–ischemia neuroprotection neurogenesis inflammation bile acids transcriptomics estrogen deficiency ovariectomized mice postmenopause gut organoids ghrelin GHSR signaling late adolescence medical cannabis polypharmacy n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20230714_9783036575827_25 |