The Ins and Outs of miRNAs as Biomarkers
miRNAs are small noncoding RNAs that control gene expression at the post-transcriptional level. It has been recognized that dysregulation of miRNAs reflects the state and function of cells and tissues, contributing to their dysfunction. The identification of hundreds of extracellular miRNAs in biolo...
Збережено в:
| Формат: | Online |
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| Мова: | Англійська |
| Опубліковано: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Предмети: | |
| Онлайн доступ: | ONIX_20230714_9783036579252_47 |
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| _version_ | 1869514618080067584 |
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| collection | Directory of Open Access Books |
| description | miRNAs are small noncoding RNAs that control gene expression at the post-transcriptional level. It has been recognized that dysregulation of miRNAs reflects the state and function of cells and tissues, contributing to their dysfunction. The identification of hundreds of extracellular miRNAs in biological fluids has underscored their potential in the field of biomarker research. In addition, the therapeutic potential of miRNAs is receiving increasing attention in numerous conditions. On the other hand, many operational issues, including stability, delivery systems, and bioavailability, have yet to be resolved. In this dynamic field, biopharmaceutical companies are increasingly engaged, and ongoing clinical trials point to anti-miR and miR-mimic molecules as novel classes of molecules for upcoming therapeutic applications. This reprint aims to provide a broad overview of current knowledge on several outstanding issues and new opportunities offered by miRNAs in the treatment of diseases and as early diagnostic tools for next-generation medicine. |
| format | Online |
| id | doab-20.500.12854ir-101348 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1013482024-03-28T03:33:11Z The Ins and Outs of miRNAs as Biomarkers Iacomino, Giuseppe Lauria, Fabio mi-RNA physical exercise gene expression stress head and neck cancer miRNA chemoresistance protocol systematic review hazard ratio patient survival up-regulation down-regulation microRNA circulating miRNA theranostic biomarkers chemosensitivity melanoma meta-analysis miRNAs microRNAs liver neoplasms angiogenesis cancer biomarkers transfection qRT-PCR plasma amplification efficiency EBV LMP1 nasopharyngeal cells expression profiling chronic low-grade inflammation inflammation-associated biomarkers overweight and obesity children/adolescents sex-related associations DNA copy number variation comparative study progenitor cells amniotic fluid leiomyoma myometrium divergent cell commitment linear dysregulation circulating microRNAs extracellular miRNA nasopharyngeal carcinoma miRNA-based diagnosis HNSCC tumor-suppressor miR-30e-5p FOXD1 TCGA cervical cancer non-coding RNAs diagnosis prognosis therapeutics regulation of gene expression alveolar epithelial type II cells type II pneumocytes ATII AECII flow cytometry autofluorescence pathway analysis TGF-beta homeostasis EMT RNA-based therapeutic personalized medicine translational medicine breast cancer diagnostics therapy response hepatitis C virus liver injury microRNA-192 microRNA-29a HCV genotype-3 thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences miRNAs are small noncoding RNAs that control gene expression at the post-transcriptional level. It has been recognized that dysregulation of miRNAs reflects the state and function of cells and tissues, contributing to their dysfunction. The identification of hundreds of extracellular miRNAs in biological fluids has underscored their potential in the field of biomarker research. In addition, the therapeutic potential of miRNAs is receiving increasing attention in numerous conditions. On the other hand, many operational issues, including stability, delivery systems, and bioavailability, have yet to be resolved. In this dynamic field, biopharmaceutical companies are increasingly engaged, and ongoing clinical trials point to anti-miR and miR-mimic molecules as novel classes of molecules for upcoming therapeutic applications. This reprint aims to provide a broad overview of current knowledge on several outstanding issues and new opportunities offered by miRNAs in the treatment of diseases and as early diagnostic tools for next-generation medicine. 2023-07-14T14:26:00Z 2023-07-14T14:26:00Z 2023 book ONIX_20230714_9783036579252_47 9783036579252 9783036579245 https://directory.doabooks.org/handle/20.500.12854/101348 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7443 https://mdpi.com/books/pdfview/book/7443 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7924-5 10.3390/books978-3-0365-7924-5 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036579252 9783036579245 254 Basel open access |
| spellingShingle | mi-RNA physical exercise gene expression stress head and neck cancer miRNA chemoresistance protocol systematic review hazard ratio patient survival up-regulation down-regulation microRNA circulating miRNA theranostic biomarkers chemosensitivity melanoma meta-analysis miRNAs microRNAs liver neoplasms angiogenesis cancer biomarkers transfection qRT-PCR plasma amplification efficiency EBV LMP1 nasopharyngeal cells expression profiling chronic low-grade inflammation inflammation-associated biomarkers overweight and obesity children/adolescents sex-related associations DNA copy number variation comparative study progenitor cells amniotic fluid leiomyoma myometrium divergent cell commitment linear dysregulation circulating microRNAs extracellular miRNA nasopharyngeal carcinoma miRNA-based diagnosis HNSCC tumor-suppressor miR-30e-5p FOXD1 TCGA cervical cancer non-coding RNAs diagnosis prognosis therapeutics regulation of gene expression alveolar epithelial type II cells type II pneumocytes ATII AECII flow cytometry autofluorescence pathway analysis TGF-beta homeostasis EMT RNA-based therapeutic personalized medicine translational medicine breast cancer diagnostics therapy response hepatitis C virus liver injury microRNA-192 microRNA-29a HCV genotype-3 thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences The Ins and Outs of miRNAs as Biomarkers |
| title | The Ins and Outs of miRNAs as Biomarkers |
| title_full | The Ins and Outs of miRNAs as Biomarkers |
| title_fullStr | The Ins and Outs of miRNAs as Biomarkers |
| title_full_unstemmed | The Ins and Outs of miRNAs as Biomarkers |
| title_short | The Ins and Outs of miRNAs as Biomarkers |
| title_sort | ins and outs of mirnas as biomarkers |
| topic | mi-RNA physical exercise gene expression stress head and neck cancer miRNA chemoresistance protocol systematic review hazard ratio patient survival up-regulation down-regulation microRNA circulating miRNA theranostic biomarkers chemosensitivity melanoma meta-analysis miRNAs microRNAs liver neoplasms angiogenesis cancer biomarkers transfection qRT-PCR plasma amplification efficiency EBV LMP1 nasopharyngeal cells expression profiling chronic low-grade inflammation inflammation-associated biomarkers overweight and obesity children/adolescents sex-related associations DNA copy number variation comparative study progenitor cells amniotic fluid leiomyoma myometrium divergent cell commitment linear dysregulation circulating microRNAs extracellular miRNA nasopharyngeal carcinoma miRNA-based diagnosis HNSCC tumor-suppressor miR-30e-5p FOXD1 TCGA cervical cancer non-coding RNAs diagnosis prognosis therapeutics regulation of gene expression alveolar epithelial type II cells type II pneumocytes ATII AECII flow cytometry autofluorescence pathway analysis TGF-beta homeostasis EMT RNA-based therapeutic personalized medicine translational medicine breast cancer diagnostics therapy response hepatitis C virus liver injury microRNA-192 microRNA-29a HCV genotype-3 thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | mi-RNA physical exercise gene expression stress head and neck cancer miRNA chemoresistance protocol systematic review hazard ratio patient survival up-regulation down-regulation microRNA circulating miRNA theranostic biomarkers chemosensitivity melanoma meta-analysis miRNAs microRNAs liver neoplasms angiogenesis cancer biomarkers transfection qRT-PCR plasma amplification efficiency EBV LMP1 nasopharyngeal cells expression profiling chronic low-grade inflammation inflammation-associated biomarkers overweight and obesity children/adolescents sex-related associations DNA copy number variation comparative study progenitor cells amniotic fluid leiomyoma myometrium divergent cell commitment linear dysregulation circulating microRNAs extracellular miRNA nasopharyngeal carcinoma miRNA-based diagnosis HNSCC tumor-suppressor miR-30e-5p FOXD1 TCGA cervical cancer non-coding RNAs diagnosis prognosis therapeutics regulation of gene expression alveolar epithelial type II cells type II pneumocytes ATII AECII flow cytometry autofluorescence pathway analysis TGF-beta homeostasis EMT RNA-based therapeutic personalized medicine translational medicine breast cancer diagnostics therapy response hepatitis C virus liver injury microRNA-192 microRNA-29a HCV genotype-3 thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20230714_9783036579252_47 |