Nanoparticles in Ocular Drug Delivery Systems
Conventional ophthalmic formulations lack prolonged drug release effects and mucoadhesive properties, decreasing their residence time in the precorneal area and, therefore, in drug penetration across ocular tissues, presenting a low bioavailability with a consequent reduction in the therapeutic effi...
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| Formatua: | Online |
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| Hizkuntza: | ingelesa |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Sarrera elektronikoa: | ONIX_20230714_9783036580036_56 |
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| _version_ | 1869518228841037824 |
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| collection | Directory of Open Access Books |
| description | Conventional ophthalmic formulations lack prolonged drug release effects and mucoadhesive properties, decreasing their residence time in the precorneal area and, therefore, in drug penetration across ocular tissues, presenting a low bioavailability with a consequent reduction in the therapeutic efficacy. These limitations are related to the physiological mechanisms of the eye, for example, the diluting effect of formulations exerted by the tear fluid, constant turnover of the tear fluid, blink reflex, limited capacity of the conjunctival sac, and drainage of formulations applied by gravity.To increase the residence time of formulations on the surface of ocular tissues and increase their ability to penetrate these tissues, different strategies can be used, namely, the use of viscosifying agents, mucoadhesive polymers, stimuli-responsive polymers, microparticles, and colloidal carriers (e.g., micelles, liposomes, nanosuspensions, nanoemulsions, polymeric, and lipid nanoparticles). This Special Issue combines the latest research and review works reporting the use of nanoparticles in ophthalmic formulations to increase their bioavailability and improve the therapeutic efficacy of ophthalmic formulations. |
| format | Online |
| id | doab-20.500.12854ir-101357 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1013572024-03-31T13:10:23Z Nanoparticles in Ocular Drug Delivery Systems Almeida, Hugo Silva, Ana Catarina nanotechnology fluorescence ocular delivery probes diagnostics PKs cyclodextrin ophthalmic fosinopril sodium niosomes encapsulation stabilization flash nanoprecipitation conjunctivitis nanoparticles zein hyaluronic acid ciprofloxacin topical ocular drug delivery transferosomes linoleic acid cyclosporine A nanoparticle drug-delivery systems retinal drug delivery inner limiting membrane photodisruption vapor nanobubbles indocyanine green pulsed laser tolnaftate spanlastics cosolvent fungal keratitis kill kinetics susceptibility cannabidiol nanoemulsion carbopol® 940 NF autoclave IOP rabbits corneal tissue engineering epithelium stroma endothelium 3D bioprinting ocular diseases sustained ocular delivery therapeutic proteins barriers of corneal tissues nanocarriers microcarriers cell-penetrating peptides hydrogels ocular drug delivery nebivolol open-angle glaucoma in situ gel Box Behnken design Poloxamer-407 kappa-carrageenan glaucoma chitosan mucoadhesion ocular bioavailability therapeutic efficacy triamcinolone acetonide nanocrystals ocular inflammation corticosteroids media milling n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries Conventional ophthalmic formulations lack prolonged drug release effects and mucoadhesive properties, decreasing their residence time in the precorneal area and, therefore, in drug penetration across ocular tissues, presenting a low bioavailability with a consequent reduction in the therapeutic efficacy. These limitations are related to the physiological mechanisms of the eye, for example, the diluting effect of formulations exerted by the tear fluid, constant turnover of the tear fluid, blink reflex, limited capacity of the conjunctival sac, and drainage of formulations applied by gravity.To increase the residence time of formulations on the surface of ocular tissues and increase their ability to penetrate these tissues, different strategies can be used, namely, the use of viscosifying agents, mucoadhesive polymers, stimuli-responsive polymers, microparticles, and colloidal carriers (e.g., micelles, liposomes, nanosuspensions, nanoemulsions, polymeric, and lipid nanoparticles). This Special Issue combines the latest research and review works reporting the use of nanoparticles in ophthalmic formulations to increase their bioavailability and improve the therapeutic efficacy of ophthalmic formulations. 2023-07-14T14:26:41Z 2023-07-14T14:26:41Z 2023 book ONIX_20230714_9783036580036_56 9783036580036 9783036580029 https://directory.doabooks.org/handle/20.500.12854/101357 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7452 https://mdpi.com/books/pdfview/book/7452 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-8002-9 10.3390/books978-3-0365-8002-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036580036 9783036580029 266 Basel open access |
| spellingShingle | nanotechnology fluorescence ocular delivery probes diagnostics PKs cyclodextrin ophthalmic fosinopril sodium niosomes encapsulation stabilization flash nanoprecipitation conjunctivitis nanoparticles zein hyaluronic acid ciprofloxacin topical ocular drug delivery transferosomes linoleic acid cyclosporine A nanoparticle drug-delivery systems retinal drug delivery inner limiting membrane photodisruption vapor nanobubbles indocyanine green pulsed laser tolnaftate spanlastics cosolvent fungal keratitis kill kinetics susceptibility cannabidiol nanoemulsion carbopol® 940 NF autoclave IOP rabbits corneal tissue engineering epithelium stroma endothelium 3D bioprinting ocular diseases sustained ocular delivery therapeutic proteins barriers of corneal tissues nanocarriers microcarriers cell-penetrating peptides hydrogels ocular drug delivery nebivolol open-angle glaucoma in situ gel Box Behnken design Poloxamer-407 kappa-carrageenan glaucoma chitosan mucoadhesion ocular bioavailability therapeutic efficacy triamcinolone acetonide nanocrystals ocular inflammation corticosteroids media milling n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries Nanoparticles in Ocular Drug Delivery Systems |
| title | Nanoparticles in Ocular Drug Delivery Systems |
| title_full | Nanoparticles in Ocular Drug Delivery Systems |
| title_fullStr | Nanoparticles in Ocular Drug Delivery Systems |
| title_full_unstemmed | Nanoparticles in Ocular Drug Delivery Systems |
| title_short | Nanoparticles in Ocular Drug Delivery Systems |
| title_sort | nanoparticles in ocular drug delivery systems |
| topic | nanotechnology fluorescence ocular delivery probes diagnostics PKs cyclodextrin ophthalmic fosinopril sodium niosomes encapsulation stabilization flash nanoprecipitation conjunctivitis nanoparticles zein hyaluronic acid ciprofloxacin topical ocular drug delivery transferosomes linoleic acid cyclosporine A nanoparticle drug-delivery systems retinal drug delivery inner limiting membrane photodisruption vapor nanobubbles indocyanine green pulsed laser tolnaftate spanlastics cosolvent fungal keratitis kill kinetics susceptibility cannabidiol nanoemulsion carbopol® 940 NF autoclave IOP rabbits corneal tissue engineering epithelium stroma endothelium 3D bioprinting ocular diseases sustained ocular delivery therapeutic proteins barriers of corneal tissues nanocarriers microcarriers cell-penetrating peptides hydrogels ocular drug delivery nebivolol open-angle glaucoma in situ gel Box Behnken design Poloxamer-407 kappa-carrageenan glaucoma chitosan mucoadhesion ocular bioavailability therapeutic efficacy triamcinolone acetonide nanocrystals ocular inflammation corticosteroids media milling n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries |
| topic_facet | nanotechnology fluorescence ocular delivery probes diagnostics PKs cyclodextrin ophthalmic fosinopril sodium niosomes encapsulation stabilization flash nanoprecipitation conjunctivitis nanoparticles zein hyaluronic acid ciprofloxacin topical ocular drug delivery transferosomes linoleic acid cyclosporine A nanoparticle drug-delivery systems retinal drug delivery inner limiting membrane photodisruption vapor nanobubbles indocyanine green pulsed laser tolnaftate spanlastics cosolvent fungal keratitis kill kinetics susceptibility cannabidiol nanoemulsion carbopol® 940 NF autoclave IOP rabbits corneal tissue engineering epithelium stroma endothelium 3D bioprinting ocular diseases sustained ocular delivery therapeutic proteins barriers of corneal tissues nanocarriers microcarriers cell-penetrating peptides hydrogels ocular drug delivery nebivolol open-angle glaucoma in situ gel Box Behnken design Poloxamer-407 kappa-carrageenan glaucoma chitosan mucoadhesion ocular bioavailability therapeutic efficacy triamcinolone acetonide nanocrystals ocular inflammation corticosteroids media milling n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries |
| url | ONIX_20230714_9783036580036_56 |