Mechanism of Action of Mycotoxins
Mycotoxins are a diverse group of chemicals that present wide toxicological responses in animals and humans. Their ingestion causes toxic effects that go from acute toxicity to long-term or chronic health disorders. Some mycotoxins have caused outbreaks of human toxicoses, and at least one mycotoxin...
محفوظ في:
| التنسيق: | Online |
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| اللغة: | الإنجليزية |
| منشور في: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| الموضوعات: | |
| الوصول للمادة أونلاين: | ONIX_20230714_9783036579238_97 |
| الوسوم: |
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| _version_ | 1869526714299711488 |
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| collection | Directory of Open Access Books |
| description | Mycotoxins are a diverse group of chemicals that present wide toxicological responses in animals and humans. Their ingestion causes toxic effects that go from acute toxicity to long-term or chronic health disorders. Some mycotoxins have caused outbreaks of human toxicoses, and at least one mycotoxin, aflatoxin B1, is an assumed human hepatocarcinogen. As part of a comprehensive effort to curtail the adverse health effects posed by mycotoxins, substantial research has been conducted to determine the mechanism of action of mycotoxins. Although much information has been obtained regarding the action of several mycotoxins, future research topics should continue to address several areas of critical concern.In vitro studies in different cell lines could detail and explain many of these mechanisms, while in vivo can give a real scenario in the development of a toxic effect. This Special Issue of Toxins collected the most recent reports on the mechanism of action of mycotoxins on single or combined mycotoxins studied in vivo or in vitro, the identification of known and unknown mycotoxins metabolites and other metabolites in different cell lines and animals or matrices (including organs, urine, or blood), and the development of analytical skills to study these mechanisms. A total of eleven papers, eight research papers and three review articles, are included in this reprint. |
| format | Online |
| id | doab-20.500.12854ir-101398 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1013982024-04-05T17:30:24Z Mechanism of Action of Mycotoxins García, Cristina Juan claudins mycotoxins intestinal barrier tight junctions food toxins infancy/childhood nutrition quality control bioaccessibility chromatography aflatoxin B1 bovine liver RNA-seq oxidative stress inflammatory response toll-like receptor 2 zearalenone zearalanone chicken lamb pig intestinal porcine jejunal epithelial cells Keap1-Nrf2 signaling pathway glucose nutrient absorption fumonisin B1 nanobody phage-display technology detoxification efficacy test fumonisin sphingolipid ceramide sphingomyelin muscle heart T-2 metabolites glutathione antioxidant enzymes mycotoxin aflatoxin toxicity metabolism swine decontamination ROS cytotoxicity plant extracts insulin resistance kidney metabolic flexibility patulin thema EDItEUR::Q Philosophy and Religion::QD Philosophy Mycotoxins are a diverse group of chemicals that present wide toxicological responses in animals and humans. Their ingestion causes toxic effects that go from acute toxicity to long-term or chronic health disorders. Some mycotoxins have caused outbreaks of human toxicoses, and at least one mycotoxin, aflatoxin B1, is an assumed human hepatocarcinogen. As part of a comprehensive effort to curtail the adverse health effects posed by mycotoxins, substantial research has been conducted to determine the mechanism of action of mycotoxins. Although much information has been obtained regarding the action of several mycotoxins, future research topics should continue to address several areas of critical concern.In vitro studies in different cell lines could detail and explain many of these mechanisms, while in vivo can give a real scenario in the development of a toxic effect. This Special Issue of Toxins collected the most recent reports on the mechanism of action of mycotoxins on single or combined mycotoxins studied in vivo or in vitro, the identification of known and unknown mycotoxins metabolites and other metabolites in different cell lines and animals or matrices (including organs, urine, or blood), and the development of analytical skills to study these mechanisms. A total of eleven papers, eight research papers and three review articles, are included in this reprint. 2023-07-14T14:29:49Z 2023-07-14T14:29:49Z 2023 book ONIX_20230714_9783036579238_97 9783036579238 9783036579221 https://directory.doabooks.org/handle/20.500.12854/101398 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7495 https://mdpi.com/books/pdfview/book/7495 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7922-1 10.3390/books978-3-0365-7922-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036579238 9783036579221 218 Basel open access |
| spellingShingle | claudins mycotoxins intestinal barrier tight junctions food toxins infancy/childhood nutrition quality control bioaccessibility chromatography aflatoxin B1 bovine liver RNA-seq oxidative stress inflammatory response toll-like receptor 2 zearalenone zearalanone chicken lamb pig intestinal porcine jejunal epithelial cells Keap1-Nrf2 signaling pathway glucose nutrient absorption fumonisin B1 nanobody phage-display technology detoxification efficacy test fumonisin sphingolipid ceramide sphingomyelin muscle heart T-2 metabolites glutathione antioxidant enzymes mycotoxin aflatoxin toxicity metabolism swine decontamination ROS cytotoxicity plant extracts insulin resistance kidney metabolic flexibility patulin thema EDItEUR::Q Philosophy and Religion::QD Philosophy Mechanism of Action of Mycotoxins |
| title | Mechanism of Action of Mycotoxins |
| title_full | Mechanism of Action of Mycotoxins |
| title_fullStr | Mechanism of Action of Mycotoxins |
| title_full_unstemmed | Mechanism of Action of Mycotoxins |
| title_short | Mechanism of Action of Mycotoxins |
| title_sort | mechanism of action of mycotoxins |
| topic | claudins mycotoxins intestinal barrier tight junctions food toxins infancy/childhood nutrition quality control bioaccessibility chromatography aflatoxin B1 bovine liver RNA-seq oxidative stress inflammatory response toll-like receptor 2 zearalenone zearalanone chicken lamb pig intestinal porcine jejunal epithelial cells Keap1-Nrf2 signaling pathway glucose nutrient absorption fumonisin B1 nanobody phage-display technology detoxification efficacy test fumonisin sphingolipid ceramide sphingomyelin muscle heart T-2 metabolites glutathione antioxidant enzymes mycotoxin aflatoxin toxicity metabolism swine decontamination ROS cytotoxicity plant extracts insulin resistance kidney metabolic flexibility patulin thema EDItEUR::Q Philosophy and Religion::QD Philosophy |
| topic_facet | claudins mycotoxins intestinal barrier tight junctions food toxins infancy/childhood nutrition quality control bioaccessibility chromatography aflatoxin B1 bovine liver RNA-seq oxidative stress inflammatory response toll-like receptor 2 zearalenone zearalanone chicken lamb pig intestinal porcine jejunal epithelial cells Keap1-Nrf2 signaling pathway glucose nutrient absorption fumonisin B1 nanobody phage-display technology detoxification efficacy test fumonisin sphingolipid ceramide sphingomyelin muscle heart T-2 metabolites glutathione antioxidant enzymes mycotoxin aflatoxin toxicity metabolism swine decontamination ROS cytotoxicity plant extracts insulin resistance kidney metabolic flexibility patulin thema EDItEUR::Q Philosophy and Religion::QD Philosophy |
| url | ONIX_20230714_9783036579238_97 |