The Molecular and Cellular Mechanisms of Inflammation and Tissue Regeneration
Wound healing has three overlapping steps: 1) coagulation and inflammation, 2) the proliferation and formation of new tissue, and 3) tissue remodeling. The initial phase of acute wound healing is the coagulation and the formation of a temporary wound matrix. This phase begins immediately after the i...
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| Format: | Online |
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| Langue: | anglais |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Accès en ligne: | ONIX_20230714_9783036578989_123 |
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| description | Wound healing has three overlapping steps: 1) coagulation and inflammation, 2) the proliferation and formation of new tissue, and 3) tissue remodeling. The initial phase of acute wound healing is the coagulation and the formation of a temporary wound matrix. This phase begins immediately after the injury and is completed within a few hours. Inflammation is crucial to the clean-up–repair process. Early inhibition of inflammation can hinder regeneration processes. Inflammation is associated with the activation of the innate immune system. At the site of inflammation, neutrophils appear first, followed by monocytes, which may differentiate into macrophages. The main function of macrophages and immune cells is to remove cell debris and microorganisms. These cells, in addition to the functions mentioned below, play an essential role in preparing the next phase by coordinating cellular processes. The second phase starts with the division of the cells. This process allows damaged and lost structures to be replaced. Granulation tissue formed by the extracellular matrix (ECM) and new blood vessels generated by angiogenesis fills the lesion. This process usually takes 2–10 days. In the final phase, the blood vessels regress, the inflammation resolves, and the granulation tissue becomes functional tissue. In this phase, the ECM transforms from a temporary ECM to a permanent collagen matrix. This phase starts 2–3 weeks after injury and can last for years if tissue regeneration is inadequate. |
| format | Online |
| id | doab-20.500.12854ir-101424 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1014242024-03-28T03:30:39Z The Molecular and Cellular Mechanisms of Inflammation and Tissue Regeneration Nikovics, Krisztina [Inflammation]   [Tissue Regeneration] [Immune Cells] [Macrophages] [Atherosclerosis] [Biomaterials] [Spinal Cord Injury] [Toll-Interleukin 1 Receptor Domain Adaptor Protein (TIRAP)] [Alumina Nanoparticles] [Organophosphorus Materials] [Reactive Oxygen Species (ROS)] [Endogenous Antioxidants] [Neuronal Remyelination] [Platelet-rich Plasma (PRP)] [Mesenchymal Stem Cell (MSC)] [Cancer Metastasis] [In Situ Hybridization] [Hybridization Chain Reaction (HCR)] thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Wound healing has three overlapping steps: 1) coagulation and inflammation, 2) the proliferation and formation of new tissue, and 3) tissue remodeling. The initial phase of acute wound healing is the coagulation and the formation of a temporary wound matrix. This phase begins immediately after the injury and is completed within a few hours. Inflammation is crucial to the clean-up–repair process. Early inhibition of inflammation can hinder regeneration processes. Inflammation is associated with the activation of the innate immune system. At the site of inflammation, neutrophils appear first, followed by monocytes, which may differentiate into macrophages. The main function of macrophages and immune cells is to remove cell debris and microorganisms. These cells, in addition to the functions mentioned below, play an essential role in preparing the next phase by coordinating cellular processes. The second phase starts with the division of the cells. This process allows damaged and lost structures to be replaced. Granulation tissue formed by the extracellular matrix (ECM) and new blood vessels generated by angiogenesis fills the lesion. This process usually takes 2–10 days. In the final phase, the blood vessels regress, the inflammation resolves, and the granulation tissue becomes functional tissue. In this phase, the ECM transforms from a temporary ECM to a permanent collagen matrix. This phase starts 2–3 weeks after injury and can last for years if tissue regeneration is inadequate. 2023-07-14T14:31:41Z 2023-07-14T14:31:41Z 2023 book ONIX_20230714_9783036578989_123 9783036578989 9783036578996 https://directory.doabooks.org/handle/20.500.12854/101424 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7524 https://mdpi.com/books/pdfview/book/7524 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7899-6 10.3390/books978-3-0365-7899-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036578989 9783036578996 232 Basel open access |
| spellingShingle | [Inflammation]   [Tissue Regeneration] [Immune Cells] [Macrophages] [Atherosclerosis] [Biomaterials] [Spinal Cord Injury] [Toll-Interleukin 1 Receptor Domain Adaptor Protein (TIRAP)] [Alumina Nanoparticles] [Organophosphorus Materials] [Reactive Oxygen Species (ROS)] [Endogenous Antioxidants] [Neuronal Remyelination] [Platelet-rich Plasma (PRP)] [Mesenchymal Stem Cell (MSC)] [Cancer Metastasis] [In Situ Hybridization] [Hybridization Chain Reaction (HCR)] thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences The Molecular and Cellular Mechanisms of Inflammation and Tissue Regeneration |
| title | The Molecular and Cellular Mechanisms of Inflammation and Tissue Regeneration |
| title_full | The Molecular and Cellular Mechanisms of Inflammation and Tissue Regeneration |
| title_fullStr | The Molecular and Cellular Mechanisms of Inflammation and Tissue Regeneration |
| title_full_unstemmed | The Molecular and Cellular Mechanisms of Inflammation and Tissue Regeneration |
| title_short | The Molecular and Cellular Mechanisms of Inflammation and Tissue Regeneration |
| title_sort | molecular and cellular mechanisms of inflammation and tissue regeneration |
| topic | [Inflammation]   [Tissue Regeneration] [Immune Cells] [Macrophages] [Atherosclerosis] [Biomaterials] [Spinal Cord Injury] [Toll-Interleukin 1 Receptor Domain Adaptor Protein (TIRAP)] [Alumina Nanoparticles] [Organophosphorus Materials] [Reactive Oxygen Species (ROS)] [Endogenous Antioxidants] [Neuronal Remyelination] [Platelet-rich Plasma (PRP)] [Mesenchymal Stem Cell (MSC)] [Cancer Metastasis] [In Situ Hybridization] [Hybridization Chain Reaction (HCR)] thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | [Inflammation]   [Tissue Regeneration] [Immune Cells] [Macrophages] [Atherosclerosis] [Biomaterials] [Spinal Cord Injury] [Toll-Interleukin 1 Receptor Domain Adaptor Protein (TIRAP)] [Alumina Nanoparticles] [Organophosphorus Materials] [Reactive Oxygen Species (ROS)] [Endogenous Antioxidants] [Neuronal Remyelination] [Platelet-rich Plasma (PRP)] [Mesenchymal Stem Cell (MSC)] [Cancer Metastasis] [In Situ Hybridization] [Hybridization Chain Reaction (HCR)] thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20230714_9783036578989_123 |