Application of Genetics and Genomics in Livestock Production
The delivery of genome sequences for most livestock species over the past 10–15 years has generated the potential to revolutionise livestock production globally, by providing farmers with the ability to match individual animals to rapidly changing climates, production systems and markets. Initially,...
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| 語言: | 英语 |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| 在線閱讀: | ONIX_20230808_9783036571447_4 |
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| collection | Directory of Open Access Books |
| description | The delivery of genome sequences for most livestock species over the past 10–15 years has generated the potential to revolutionise livestock production globally, by providing farmers with the ability to match individual animals to rapidly changing climates, production systems and markets. Initially, technologies such as marker-assisted selection, functional genomics, gene expression, transcriptomics, proteomics and metabolomics were hailed as technologies with the greatest promise of delivering on that potential. To date, however, their potential for the delivery of practical solutions for livestock farmers is still to be realised, though they do provide supportive evidence of value to other approaches. Gene editing using tools such as CRISPR-Cas9 also show strong promise, but face regulatory hurdles before practical applications can be delivered for use by farmers. The technology that has had the greatest impact to date is genomic selection. This year marks 20 years since genomic selection was developed by Meuwissen, Hayes and Goddard (Genetics, 2001, 157: 1819-1829) and genomic selection has been successfully applied in livestock, plants and even human health applications. However, genomic selection also faces ongoing limitations around lack of essential phenotypes, particularly for expensive or difficult-to-measure traits and possibly the need for faster/greater computational capacity. It is therefore timely to examine the impact of genomic technologies generally, and to identify successes and limitations that need to be overcome in order to achieve practical applications for livestock producers in future. |
| format | Online |
| id | doab-20.500.12854ir-112436 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1124362024-03-28T03:31:24Z Application of Genetics and Genomics in Livestock Production Burrow, Heather Goddard, Michael DNA pooling parentage reproduction genomic relationship genomic prediction genomic selection smallholder farmers beef and dairy cattle sheep and goats phenotypes reference populations capacity-building value of genomic information OTUD7A goose inflammation immune nonalcoholic fatty liver disease high density genotyping imputation sequencing reference population ssGBLUP ssGTBLUP genomic evaluation single-step Holstein genetic groups metafounder positive selection adaptive introgression runs of homozygosity haplotype cattle bursa of Fabricius development degradation chicken transcriptomic analysis genotype by environment breeding strategies selection index response circRNAs DPCs cashmere goats HOXC8 RSPO1 CCBE1 implementation strategy beef cattle tropical environments crossbreeding within-breed selection productive traits resistance to environmental stressors breed conservation causal variants linkage disequilibrium quantitative trait loci fertility heritability genetic evaluation variance components index selection n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes The delivery of genome sequences for most livestock species over the past 10–15 years has generated the potential to revolutionise livestock production globally, by providing farmers with the ability to match individual animals to rapidly changing climates, production systems and markets. Initially, technologies such as marker-assisted selection, functional genomics, gene expression, transcriptomics, proteomics and metabolomics were hailed as technologies with the greatest promise of delivering on that potential. To date, however, their potential for the delivery of practical solutions for livestock farmers is still to be realised, though they do provide supportive evidence of value to other approaches. Gene editing using tools such as CRISPR-Cas9 also show strong promise, but face regulatory hurdles before practical applications can be delivered for use by farmers. The technology that has had the greatest impact to date is genomic selection. This year marks 20 years since genomic selection was developed by Meuwissen, Hayes and Goddard (Genetics, 2001, 157: 1819-1829) and genomic selection has been successfully applied in livestock, plants and even human health applications. However, genomic selection also faces ongoing limitations around lack of essential phenotypes, particularly for expensive or difficult-to-measure traits and possibly the need for faster/greater computational capacity. It is therefore timely to examine the impact of genomic technologies generally, and to identify successes and limitations that need to be overcome in order to achieve practical applications for livestock producers in future. 2023-08-08T15:11:04Z 2023-08-08T15:11:04Z 2023 book ONIX_20230808_9783036571447_4 9783036571447 9783036571454 https://directory.doabooks.org/handle/20.500.12854/112436 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7547 https://mdpi.com/books/pdfview/book/7547 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7145-4 10.3390/books978-3-0365-7145-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036571447 9783036571454 222 Basel open access |
| spellingShingle | DNA pooling parentage reproduction genomic relationship genomic prediction genomic selection smallholder farmers beef and dairy cattle sheep and goats phenotypes reference populations capacity-building value of genomic information OTUD7A goose inflammation immune nonalcoholic fatty liver disease high density genotyping imputation sequencing reference population ssGBLUP ssGTBLUP genomic evaluation single-step Holstein genetic groups metafounder positive selection adaptive introgression runs of homozygosity haplotype cattle bursa of Fabricius development degradation chicken transcriptomic analysis genotype by environment breeding strategies selection index response circRNAs DPCs cashmere goats HOXC8 RSPO1 CCBE1 implementation strategy beef cattle tropical environments crossbreeding within-breed selection productive traits resistance to environmental stressors breed conservation causal variants linkage disequilibrium quantitative trait loci fertility heritability genetic evaluation variance components index selection n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes Application of Genetics and Genomics in Livestock Production |
| title | Application of Genetics and Genomics in Livestock Production |
| title_full | Application of Genetics and Genomics in Livestock Production |
| title_fullStr | Application of Genetics and Genomics in Livestock Production |
| title_full_unstemmed | Application of Genetics and Genomics in Livestock Production |
| title_short | Application of Genetics and Genomics in Livestock Production |
| title_sort | application of genetics and genomics in livestock production |
| topic | DNA pooling parentage reproduction genomic relationship genomic prediction genomic selection smallholder farmers beef and dairy cattle sheep and goats phenotypes reference populations capacity-building value of genomic information OTUD7A goose inflammation immune nonalcoholic fatty liver disease high density genotyping imputation sequencing reference population ssGBLUP ssGTBLUP genomic evaluation single-step Holstein genetic groups metafounder positive selection adaptive introgression runs of homozygosity haplotype cattle bursa of Fabricius development degradation chicken transcriptomic analysis genotype by environment breeding strategies selection index response circRNAs DPCs cashmere goats HOXC8 RSPO1 CCBE1 implementation strategy beef cattle tropical environments crossbreeding within-breed selection productive traits resistance to environmental stressors breed conservation causal variants linkage disequilibrium quantitative trait loci fertility heritability genetic evaluation variance components index selection n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes |
| topic_facet | DNA pooling parentage reproduction genomic relationship genomic prediction genomic selection smallholder farmers beef and dairy cattle sheep and goats phenotypes reference populations capacity-building value of genomic information OTUD7A goose inflammation immune nonalcoholic fatty liver disease high density genotyping imputation sequencing reference population ssGBLUP ssGTBLUP genomic evaluation single-step Holstein genetic groups metafounder positive selection adaptive introgression runs of homozygosity haplotype cattle bursa of Fabricius development degradation chicken transcriptomic analysis genotype by environment breeding strategies selection index response circRNAs DPCs cashmere goats HOXC8 RSPO1 CCBE1 implementation strategy beef cattle tropical environments crossbreeding within-breed selection productive traits resistance to environmental stressors breed conservation causal variants linkage disequilibrium quantitative trait loci fertility heritability genetic evaluation variance components index selection n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes |
| url | ONIX_20230808_9783036571447_4 |