Risk Assessment of Nanomaterials Toxicity
Regarding the increasing use of nanomaterials in almost every area of our daily life, toxicological risk assessment is one of the major requirements for their safe handling. Especially at workplaces, inhalation is the major route of exposure and potential toxicity, and effects on the lung need to be...
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| Materialtyp: | Online |
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| Språk: | engelska |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Länkar: | ONIX_20230808_9783036578125_39 |
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| _version_ | 1869518704840015872 |
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| collection | Directory of Open Access Books |
| description | Regarding the increasing use of nanomaterials in almost every area of our daily life, toxicological risk assessment is one of the major requirements for their safe handling. Especially at workplaces, inhalation is the major route of exposure and potential toxicity, and effects on the lung need to be considered. Furthermore, neurotoxicity associated with exposure to nanomaterials is a growing field of scientific investigation. However, not every single nanomaterial can be assessed in long-term animal inhalation studies, due to limited resources as well as political and societal efforts to reduce animal experiments according to the 3R principles. Thus, during the last few years, significant efforts have been dedicated to grouping nanomaterials, mainly based on advanced in vitro models. These new approach methodologies (NAMs) include detailed characterization of the respective materials in physiologically relevant media, but also more realistic exposure systems, such as co-cultures, also at the air–liquid interface, combined with comprehensive cellular investigations that provide quite detailed toxicological profiles. Thus, nanoparticles show differences in toxicity depending on their size, surface reactivity, and dissolution kinetics. Adverse cellular effects include inflammation, genotoxicity, oxidative stress, and epigenetic alterations. This Special Issue aims to highlight the recent advances in the mechanisms of nanomaterial toxicity, as well as the approaches for risk assessment, linking nanoparticle characteristics as well as in vitro toxicity to in vivo observations for advanced risk assessment. |
| format | Online |
| id | doab-20.500.12854ir-112471 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1124712024-04-09T23:16:33Z Risk Assessment of Nanomaterials Toxicity Hartwig, Andrea van Thriel, Christoph nanotoxicology titanium dioxide synthetic amorphous silica agglomerates and aggregates realistic exposure in vitro nanomaterials agglomerates air-liquid interface pulmonary toxicity metal-based nanoparticles and nanowires solubility intracellular bioavailability oxidative reactivity comet assay FADU assay engineered nanomaterials DNA strand breaks genotoxicity ENM interference hazard assessment database lung toxicity study quality nanoparticles gene regulation endocytosis inflammation NR4A1 interlaboratory comparison minimal information quality criteria description standards graphene 2D nanoplates lung inhalation toxicity in vitro Cr2O3 particles Cr(VI) release cytotoxicity gene expression profiles DNA damage signaling DNA repair proteins oxidative stress cell death pathways NAMs—new approach methodologies ALI—air–liquid interface BEAS-2B A549 NM-300K DNA damage chromosomal damage cytokines TiO2 NPs titanium dental implants 3D spheroids osteoblasts safe-by-design hazard testing in vitro methods SAbyNA advanced materials carbon nanotubes in vitro models respiratory tract bronchial epithelium alveolar epithelium ciliary beating frequency n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues Regarding the increasing use of nanomaterials in almost every area of our daily life, toxicological risk assessment is one of the major requirements for their safe handling. Especially at workplaces, inhalation is the major route of exposure and potential toxicity, and effects on the lung need to be considered. Furthermore, neurotoxicity associated with exposure to nanomaterials is a growing field of scientific investigation. However, not every single nanomaterial can be assessed in long-term animal inhalation studies, due to limited resources as well as political and societal efforts to reduce animal experiments according to the 3R principles. Thus, during the last few years, significant efforts have been dedicated to grouping nanomaterials, mainly based on advanced in vitro models. These new approach methodologies (NAMs) include detailed characterization of the respective materials in physiologically relevant media, but also more realistic exposure systems, such as co-cultures, also at the air–liquid interface, combined with comprehensive cellular investigations that provide quite detailed toxicological profiles. Thus, nanoparticles show differences in toxicity depending on their size, surface reactivity, and dissolution kinetics. Adverse cellular effects include inflammation, genotoxicity, oxidative stress, and epigenetic alterations. This Special Issue aims to highlight the recent advances in the mechanisms of nanomaterial toxicity, as well as the approaches for risk assessment, linking nanoparticle characteristics as well as in vitro toxicity to in vivo observations for advanced risk assessment. 2023-08-08T15:13:47Z 2023-08-08T15:13:47Z 2023 book ONIX_20230808_9783036578125_39 9783036578125 9783036578132 https://directory.doabooks.org/handle/20.500.12854/112471 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7586 https://mdpi.com/books/pdfview/book/7586 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7813-2 10.3390/books978-3-0365-7813-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036578125 9783036578132 304 Basel open access |
| spellingShingle | nanotoxicology titanium dioxide synthetic amorphous silica agglomerates and aggregates realistic exposure in vitro nanomaterials agglomerates air-liquid interface pulmonary toxicity metal-based nanoparticles and nanowires solubility intracellular bioavailability oxidative reactivity comet assay FADU assay engineered nanomaterials DNA strand breaks genotoxicity ENM interference hazard assessment database lung toxicity study quality nanoparticles gene regulation endocytosis inflammation NR4A1 interlaboratory comparison minimal information quality criteria description standards graphene 2D nanoplates lung inhalation toxicity in vitro Cr2O3 particles Cr(VI) release cytotoxicity gene expression profiles DNA damage signaling DNA repair proteins oxidative stress cell death pathways NAMs—new approach methodologies ALI—air–liquid interface BEAS-2B A549 NM-300K DNA damage chromosomal damage cytokines TiO2 NPs titanium dental implants 3D spheroids osteoblasts safe-by-design hazard testing in vitro methods SAbyNA advanced materials carbon nanotubes in vitro models respiratory tract bronchial epithelium alveolar epithelium ciliary beating frequency n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues Risk Assessment of Nanomaterials Toxicity |
| title | Risk Assessment of Nanomaterials Toxicity |
| title_full | Risk Assessment of Nanomaterials Toxicity |
| title_fullStr | Risk Assessment of Nanomaterials Toxicity |
| title_full_unstemmed | Risk Assessment of Nanomaterials Toxicity |
| title_short | Risk Assessment of Nanomaterials Toxicity |
| title_sort | risk assessment of nanomaterials toxicity |
| topic | nanotoxicology titanium dioxide synthetic amorphous silica agglomerates and aggregates realistic exposure in vitro nanomaterials agglomerates air-liquid interface pulmonary toxicity metal-based nanoparticles and nanowires solubility intracellular bioavailability oxidative reactivity comet assay FADU assay engineered nanomaterials DNA strand breaks genotoxicity ENM interference hazard assessment database lung toxicity study quality nanoparticles gene regulation endocytosis inflammation NR4A1 interlaboratory comparison minimal information quality criteria description standards graphene 2D nanoplates lung inhalation toxicity in vitro Cr2O3 particles Cr(VI) release cytotoxicity gene expression profiles DNA damage signaling DNA repair proteins oxidative stress cell death pathways NAMs—new approach methodologies ALI—air–liquid interface BEAS-2B A549 NM-300K DNA damage chromosomal damage cytokines TiO2 NPs titanium dental implants 3D spheroids osteoblasts safe-by-design hazard testing in vitro methods SAbyNA advanced materials carbon nanotubes in vitro models respiratory tract bronchial epithelium alveolar epithelium ciliary beating frequency n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues |
| topic_facet | nanotoxicology titanium dioxide synthetic amorphous silica agglomerates and aggregates realistic exposure in vitro nanomaterials agglomerates air-liquid interface pulmonary toxicity metal-based nanoparticles and nanowires solubility intracellular bioavailability oxidative reactivity comet assay FADU assay engineered nanomaterials DNA strand breaks genotoxicity ENM interference hazard assessment database lung toxicity study quality nanoparticles gene regulation endocytosis inflammation NR4A1 interlaboratory comparison minimal information quality criteria description standards graphene 2D nanoplates lung inhalation toxicity in vitro Cr2O3 particles Cr(VI) release cytotoxicity gene expression profiles DNA damage signaling DNA repair proteins oxidative stress cell death pathways NAMs—new approach methodologies ALI—air–liquid interface BEAS-2B A549 NM-300K DNA damage chromosomal damage cytokines TiO2 NPs titanium dental implants 3D spheroids osteoblasts safe-by-design hazard testing in vitro methods SAbyNA advanced materials carbon nanotubes in vitro models respiratory tract bronchial epithelium alveolar epithelium ciliary beating frequency n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues |
| url | ONIX_20230808_9783036578125_39 |