Molecular Research of Alzheimer's Disease
The incidence and prevalence of Alzheimer's Disease are increasing worldwide due to aging and comorbidities. The classical neuropathogenetic model, which concentrates on brain amyloid plaque deposition, neurofibrillary tangles, and cholinergic system dysfunction, is being expanded and integrated wit...
Պահպանված է:
| Ձևաչափ: | Online |
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| Լեզու: | անգլերեն |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Խորագրեր: | |
| Առցանց հասանելիություն: | ONIX_20230911_9783036584386_105 |
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Չկան պիտակներ, Եղեք առաջինը, ով նշում է այս գրառումը!
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| _version_ | 1869526319933423616 |
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| collection | Directory of Open Access Books |
| description | The incidence and prevalence of Alzheimer's Disease are increasing worldwide due to aging and comorbidities. The classical neuropathogenetic model, which concentrates on brain amyloid plaque deposition, neurofibrillary tangles, and cholinergic system dysfunction, is being expanded and integrated with newer molecular models. Understanding the relationships between the classical pathogenetic pathways and newer hypotheses is imperative for guiding future research and developing effective drugs. The existence of newer molecular mechanisms such as risk factors, comorbidities like vascular diseases and diabetes mellitus, and neuroanatomical/neurofunctional alterations as blood–brain barrier breakdown and neurovascular unit dysfunction, offer potential targets to improve Alzheimer's Disease diagnosis and treatment. This reprint provides an overview of the pathophysiologic role of newer and older molecular mechanisms of Alzheimer's Disease, shedding light on new insights for the development of new therapeutic approaches. It also highlights newer candidate markers of disease onset and progression. |
| format | Online |
| id | doab-20.500.12854ir-113972 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1139722024-03-31T13:08:20Z Molecular Research of Alzheimer's Disease Falsetti, Lorenzo Alzheimer&rsquo s disease mild cognitive impairment type 3 diabetes mellitus MCI neurovascular unit neurovascular unit dysfunction blood&ndash brain barrier brain barrier disruption atherosclerosis biomarkers prognosis diagnosis thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology The incidence and prevalence of Alzheimer's Disease are increasing worldwide due to aging and comorbidities. The classical neuropathogenetic model, which concentrates on brain amyloid plaque deposition, neurofibrillary tangles, and cholinergic system dysfunction, is being expanded and integrated with newer molecular models. Understanding the relationships between the classical pathogenetic pathways and newer hypotheses is imperative for guiding future research and developing effective drugs. The existence of newer molecular mechanisms such as risk factors, comorbidities like vascular diseases and diabetes mellitus, and neuroanatomical/neurofunctional alterations as blood–brain barrier breakdown and neurovascular unit dysfunction, offer potential targets to improve Alzheimer's Disease diagnosis and treatment. This reprint provides an overview of the pathophysiologic role of newer and older molecular mechanisms of Alzheimer's Disease, shedding light on new insights for the development of new therapeutic approaches. It also highlights newer candidate markers of disease onset and progression. 2023-09-11T12:14:31Z 2023-09-11T12:14:31Z 2023 book ONIX_20230911_9783036584386_105 9783036584386 9783036584393 https://directory.doabooks.org/handle/20.500.12854/113972 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/7816 https://mdpi.com/books/pdfview/book/7816 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-8439-3 10.3390/books978-3-0365-8439-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036584386 9783036584393 206 open access |
| spellingShingle | Alzheimer&rsquo s disease mild cognitive impairment type 3 diabetes mellitus MCI neurovascular unit neurovascular unit dysfunction blood&ndash brain barrier brain barrier disruption atherosclerosis biomarkers prognosis diagnosis thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology Molecular Research of Alzheimer's Disease |
| title | Molecular Research of Alzheimer's Disease |
| title_full | Molecular Research of Alzheimer's Disease |
| title_fullStr | Molecular Research of Alzheimer's Disease |
| title_full_unstemmed | Molecular Research of Alzheimer's Disease |
| title_short | Molecular Research of Alzheimer's Disease |
| title_sort | molecular research of alzheimer s disease |
| topic | Alzheimer&rsquo s disease mild cognitive impairment type 3 diabetes mellitus MCI neurovascular unit neurovascular unit dysfunction blood&ndash brain barrier brain barrier disruption atherosclerosis biomarkers prognosis diagnosis thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology |
| topic_facet | Alzheimer&rsquo s disease mild cognitive impairment type 3 diabetes mellitus MCI neurovascular unit neurovascular unit dysfunction blood&ndash brain barrier brain barrier disruption atherosclerosis biomarkers prognosis diagnosis thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology |
| url | ONIX_20230911_9783036584386_105 |