Glutathione: Chemistry and Biochemistry
It has been known that cellular glutathione content and its speciation play a role, among others, in redox homeostasis, cell cycle control, immunological defense, and pathological abnormalities. Furthermore, it plays a significant role in the biotransformation of drugs and other endogenous or exogen...
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| Formato: | Online |
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| Lenguaje: | inglés |
| Publicado: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Materias: | |
| Acceso en línea: | ONIX_20230911_9783036586670_112 |
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| _version_ | 1869531344765190144 |
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| collection | Directory of Open Access Books |
| description | It has been known that cellular glutathione content and its speciation play a role, among others, in redox homeostasis, cell cycle control, immunological defense, and pathological abnormalities. Furthermore, it plays a significant role in the biotransformation of drugs and other endogenous or exogenous electrophilic species. Most of these cellular functions are related to the thiol function of the cysteine moiety.This reprint presents the publications that appeared in the Special Issue of Molecules, “Glutathione: Chemistry and Biochemistry.” The first three contributions review the present-day knowledge of the GSH/GSSG system and the most important GSH-related proteins involved in regulating various cellular events. The subsequent four contributions present selected interventions that modulate the GSSG/2GSH system. One of the contributions to this session describes a new HPLC method to quantify the reduced and oxidized glutathione levels. The third session involves three contributions demonstrating the role of GSH in the metabolism of different candidate and clinically used anticancer drugs. One of the contributions, a theoretical work, provides helpful information for developing GSH analogs with high ACE inhibitor activity.By purpose and content, this Special Issue is addressed to the vast number of life science researchers (academic and industrial) and medical professionals who are interested in or already engaged in research that involves glutathione. |
| format | Online |
| id | doab-20.500.12854ir-113979 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1139792024-03-28T03:30:40Z Glutathione: Chemistry and Biochemistry Perjési, Pál cyclophosphamide autoimmune diseases glutathione glutathione-S-transferase polymorphism glutaredoxin iron-sulfur cluster iron S-glutathionylation S-nitrosylation GSH nitrosoglutathione redox-regulation polymerized whey protein physicochemical properties pharmacokinetics toxicity chalcone cysteine thiols Michael addition diastereoselective addition reactive oxygen species oxidative stress nanotoxicity cell injury fluorescence probes brain liquid chromatography diode array detector anticancer drugs mechanisms of glutathione conjugation reaction detoxification bioactivation sulodexide endothelial cells ischemia apoptosis GSSG GCLc GSS redox potential supramolecular arrangement M06-2X/6-311++G(d,p) DFT molecular docking angiotensin-converting enzyme cell redox homeostasis glutathionylation glutathione system glutathione enzyme n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences It has been known that cellular glutathione content and its speciation play a role, among others, in redox homeostasis, cell cycle control, immunological defense, and pathological abnormalities. Furthermore, it plays a significant role in the biotransformation of drugs and other endogenous or exogenous electrophilic species. Most of these cellular functions are related to the thiol function of the cysteine moiety.This reprint presents the publications that appeared in the Special Issue of Molecules, “Glutathione: Chemistry and Biochemistry.” The first three contributions review the present-day knowledge of the GSH/GSSG system and the most important GSH-related proteins involved in regulating various cellular events. The subsequent four contributions present selected interventions that modulate the GSSG/2GSH system. One of the contributions to this session describes a new HPLC method to quantify the reduced and oxidized glutathione levels. The third session involves three contributions demonstrating the role of GSH in the metabolism of different candidate and clinically used anticancer drugs. One of the contributions, a theoretical work, provides helpful information for developing GSH analogs with high ACE inhibitor activity.By purpose and content, this Special Issue is addressed to the vast number of life science researchers (academic and industrial) and medical professionals who are interested in or already engaged in research that involves glutathione. 2023-09-11T12:16:09Z 2023-09-11T12:16:09Z 2023 book ONIX_20230911_9783036586670_112 9783036586670 9783036586663 https://directory.doabooks.org/handle/20.500.12854/113979 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/7823 https://mdpi.com/books/pdfview/book/7823 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-8666-3 10.3390/books978-3-0365-8666-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 d48f09f2-08c2-4dde-ba80-93d6046f4ca2 9783036586670 9783036586663 212 open access |
| spellingShingle | cyclophosphamide autoimmune diseases glutathione glutathione-S-transferase polymorphism glutaredoxin iron-sulfur cluster iron S-glutathionylation S-nitrosylation GSH nitrosoglutathione redox-regulation polymerized whey protein physicochemical properties pharmacokinetics toxicity chalcone cysteine thiols Michael addition diastereoselective addition reactive oxygen species oxidative stress nanotoxicity cell injury fluorescence probes brain liquid chromatography diode array detector anticancer drugs mechanisms of glutathione conjugation reaction detoxification bioactivation sulodexide endothelial cells ischemia apoptosis GSSG GCLc GSS redox potential supramolecular arrangement M06-2X/6-311++G(d,p) DFT molecular docking angiotensin-converting enzyme cell redox homeostasis glutathionylation glutathione system glutathione enzyme n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Glutathione: Chemistry and Biochemistry |
| title | Glutathione: Chemistry and Biochemistry |
| title_full | Glutathione: Chemistry and Biochemistry |
| title_fullStr | Glutathione: Chemistry and Biochemistry |
| title_full_unstemmed | Glutathione: Chemistry and Biochemistry |
| title_short | Glutathione: Chemistry and Biochemistry |
| title_sort | glutathione chemistry and biochemistry |
| topic | cyclophosphamide autoimmune diseases glutathione glutathione-S-transferase polymorphism glutaredoxin iron-sulfur cluster iron S-glutathionylation S-nitrosylation GSH nitrosoglutathione redox-regulation polymerized whey protein physicochemical properties pharmacokinetics toxicity chalcone cysteine thiols Michael addition diastereoselective addition reactive oxygen species oxidative stress nanotoxicity cell injury fluorescence probes brain liquid chromatography diode array detector anticancer drugs mechanisms of glutathione conjugation reaction detoxification bioactivation sulodexide endothelial cells ischemia apoptosis GSSG GCLc GSS redox potential supramolecular arrangement M06-2X/6-311++G(d,p) DFT molecular docking angiotensin-converting enzyme cell redox homeostasis glutathionylation glutathione system glutathione enzyme n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | cyclophosphamide autoimmune diseases glutathione glutathione-S-transferase polymorphism glutaredoxin iron-sulfur cluster iron S-glutathionylation S-nitrosylation GSH nitrosoglutathione redox-regulation polymerized whey protein physicochemical properties pharmacokinetics toxicity chalcone cysteine thiols Michael addition diastereoselective addition reactive oxygen species oxidative stress nanotoxicity cell injury fluorescence probes brain liquid chromatography diode array detector anticancer drugs mechanisms of glutathione conjugation reaction detoxification bioactivation sulodexide endothelial cells ischemia apoptosis GSSG GCLc GSS redox potential supramolecular arrangement M06-2X/6-311++G(d,p) DFT molecular docking angiotensin-converting enzyme cell redox homeostasis glutathionylation glutathione system glutathione enzyme n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20230911_9783036586670_112 |