Molecular Mechanisms of Synaptic Plasticity: Dynamic Changes in Neurons Functions
The human brain has hundreds of billions of neurons, and at least 7 million dendrites have been hypothesized to exist for each neuron, with over 100 trillion neuron–neuron, neuron–muscle, and neuron–endocrine cell synapses [1,2]. Our body continually receives stimuli from the outer environment, and...
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| Sprog: | engelsk |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Online adgang: | ONIX_20230911_9783036587158_127 |
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| description | The human brain has hundreds of billions of neurons, and at least 7 million dendrites have been hypothesized to exist for each neuron, with over 100 trillion neuron–neuron, neuron–muscle, and neuron–endocrine cell synapses [1,2]. Our body continually receives stimuli from the outer environment, and our brain’s ability to respond to these stimuli is ensured through synaptic processes, motivating the foundations of this Special Issue.This reprint aims to underline the role of synaptic plasticity phenomena in our body and clarify the mechanism operated by neurons to guarantee these phenomena. The collection in the Issue comprises 14 papers, including 8 reviews and 6 original works, one of which is a protocol for differentiating neurons from human stem cells, and 5 are preclinical works. |
| format | Online |
| id | doab-20.500.12854ir-113994 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1139942024-03-28T03:33:26Z Molecular Mechanisms of Synaptic Plasticity: Dynamic Changes in Neurons Functions Martella, Giuseppina autophagy proteasome immunoproteasome mTOR T-cells glia dopamine glutamate neuro-inflammation glucocorticoids noradrenaline tyrosine hydroxylase reticular formation dopamine transporter Parkinson’s disease PINK1 caspase-3 striatum synaptic plasticity long-term depression brain networks connectivity Alzheimer’s disease (AD) schizophrenia long-term potentiation (LTP) synaptic scaling resting state functional MRI (rs-fMRI) inflammation multiple sclerosis neuregulins ErbB receptors LTP LTD hippocampus midbrain dopamine neurons brain connectivity brain development gut-brain axis neurodevelopmental diseases neuronal cytoarchitecture neuroplasticity regulatory T cells serotonin (5-HT) endocannabinoid system spatial learning dorsal striatum amygdala Circular Hole Board AM251 mice dystonia D2 receptors synapses dopamine volume transmission SNARE proteins long-term potentiation learning and memory cognition Schaffer collateral-CA1 synapses tripartite synapse neurovascular unit systems biology Glutamate NMDA receptors dendritic spines brain disorders transmission electron microscopy human neurons induced neural stem cells synapse synaptic vesicles high contrast inhibition computational neuroscience GABA n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences The human brain has hundreds of billions of neurons, and at least 7 million dendrites have been hypothesized to exist for each neuron, with over 100 trillion neuron–neuron, neuron–muscle, and neuron–endocrine cell synapses [1,2]. Our body continually receives stimuli from the outer environment, and our brain’s ability to respond to these stimuli is ensured through synaptic processes, motivating the foundations of this Special Issue.This reprint aims to underline the role of synaptic plasticity phenomena in our body and clarify the mechanism operated by neurons to guarantee these phenomena. The collection in the Issue comprises 14 papers, including 8 reviews and 6 original works, one of which is a protocol for differentiating neurons from human stem cells, and 5 are preclinical works. 2023-09-11T12:19:59Z 2023-09-11T12:19:59Z 2023 book ONIX_20230911_9783036587158_127 9783036587158 9783036587141 https://directory.doabooks.org/handle/20.500.12854/113994 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/7838 https://mdpi.com/books/pdfview/book/7838 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-8714-1 10.3390/books978-3-0365-8714-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036587158 9783036587141 290 open access |
| spellingShingle | autophagy proteasome immunoproteasome mTOR T-cells glia dopamine glutamate neuro-inflammation glucocorticoids noradrenaline tyrosine hydroxylase reticular formation dopamine transporter Parkinson’s disease PINK1 caspase-3 striatum synaptic plasticity long-term depression brain networks connectivity Alzheimer’s disease (AD) schizophrenia long-term potentiation (LTP) synaptic scaling resting state functional MRI (rs-fMRI) inflammation multiple sclerosis neuregulins ErbB receptors LTP LTD hippocampus midbrain dopamine neurons brain connectivity brain development gut-brain axis neurodevelopmental diseases neuronal cytoarchitecture neuroplasticity regulatory T cells serotonin (5-HT) endocannabinoid system spatial learning dorsal striatum amygdala Circular Hole Board AM251 mice dystonia D2 receptors synapses dopamine volume transmission SNARE proteins long-term potentiation learning and memory cognition Schaffer collateral-CA1 synapses tripartite synapse neurovascular unit systems biology Glutamate NMDA receptors dendritic spines brain disorders transmission electron microscopy human neurons induced neural stem cells synapse synaptic vesicles high contrast inhibition computational neuroscience GABA n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Molecular Mechanisms of Synaptic Plasticity: Dynamic Changes in Neurons Functions |
| title | Molecular Mechanisms of Synaptic Plasticity: Dynamic Changes in Neurons Functions |
| title_full | Molecular Mechanisms of Synaptic Plasticity: Dynamic Changes in Neurons Functions |
| title_fullStr | Molecular Mechanisms of Synaptic Plasticity: Dynamic Changes in Neurons Functions |
| title_full_unstemmed | Molecular Mechanisms of Synaptic Plasticity: Dynamic Changes in Neurons Functions |
| title_short | Molecular Mechanisms of Synaptic Plasticity: Dynamic Changes in Neurons Functions |
| title_sort | molecular mechanisms of synaptic plasticity dynamic changes in neurons functions |
| topic | autophagy proteasome immunoproteasome mTOR T-cells glia dopamine glutamate neuro-inflammation glucocorticoids noradrenaline tyrosine hydroxylase reticular formation dopamine transporter Parkinson’s disease PINK1 caspase-3 striatum synaptic plasticity long-term depression brain networks connectivity Alzheimer’s disease (AD) schizophrenia long-term potentiation (LTP) synaptic scaling resting state functional MRI (rs-fMRI) inflammation multiple sclerosis neuregulins ErbB receptors LTP LTD hippocampus midbrain dopamine neurons brain connectivity brain development gut-brain axis neurodevelopmental diseases neuronal cytoarchitecture neuroplasticity regulatory T cells serotonin (5-HT) endocannabinoid system spatial learning dorsal striatum amygdala Circular Hole Board AM251 mice dystonia D2 receptors synapses dopamine volume transmission SNARE proteins long-term potentiation learning and memory cognition Schaffer collateral-CA1 synapses tripartite synapse neurovascular unit systems biology Glutamate NMDA receptors dendritic spines brain disorders transmission electron microscopy human neurons induced neural stem cells synapse synaptic vesicles high contrast inhibition computational neuroscience GABA n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | autophagy proteasome immunoproteasome mTOR T-cells glia dopamine glutamate neuro-inflammation glucocorticoids noradrenaline tyrosine hydroxylase reticular formation dopamine transporter Parkinson’s disease PINK1 caspase-3 striatum synaptic plasticity long-term depression brain networks connectivity Alzheimer’s disease (AD) schizophrenia long-term potentiation (LTP) synaptic scaling resting state functional MRI (rs-fMRI) inflammation multiple sclerosis neuregulins ErbB receptors LTP LTD hippocampus midbrain dopamine neurons brain connectivity brain development gut-brain axis neurodevelopmental diseases neuronal cytoarchitecture neuroplasticity regulatory T cells serotonin (5-HT) endocannabinoid system spatial learning dorsal striatum amygdala Circular Hole Board AM251 mice dystonia D2 receptors synapses dopamine volume transmission SNARE proteins long-term potentiation learning and memory cognition Schaffer collateral-CA1 synapses tripartite synapse neurovascular unit systems biology Glutamate NMDA receptors dendritic spines brain disorders transmission electron microscopy human neurons induced neural stem cells synapse synaptic vesicles high contrast inhibition computational neuroscience GABA n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20230911_9783036587158_127 |