Chapter 8 Hyaluronan-Based Hydrogels as Functional Vectors for Standardised Therapeutics in Tissue Engineering and Regenerative Medicine
Hyaluronan-based hydrogels are optimal candidates when developing novel combined advanced therapy medicinal products (cATMP), tissue engineering products (TEP), and medical devices. The key physico-chemical properties of hydrogels may hinder, mediate, or stimulate therapeutic potentials borne by sta...
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| Format: | Online |
| Language: | English |
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Taylor & Francis
2023
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| Online Access: | https://library.oapen.org/handle/20.500.12657/76457 |
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| author | Porcello, Alexandre Laurent, Alexis Hirt-Burri, Nathalie Abdel-Sayed, Philippe de Buys Roessingh, Anthony Raffoul, Wassim Jordan, Olivier Allémann, Eric Applegate, Lee Ann |
| author_browse | Abdel-Sayed, Philippe Allémann, Eric Applegate, Lee Ann Hirt-Burri, Nathalie Jordan, Olivier Laurent, Alexis Porcello, Alexandre Raffoul, Wassim de Buys Roessingh, Anthony |
| author_facet | Porcello, Alexandre Laurent, Alexis Hirt-Burri, Nathalie Abdel-Sayed, Philippe de Buys Roessingh, Anthony Raffoul, Wassim Jordan, Olivier Allémann, Eric Applegate, Lee Ann |
| author_sort | Porcello, Alexandre |
| collection | Directory of Open Access Books |
| description | Hyaluronan-based hydrogels are optimal candidates when developing novel combined advanced therapy medicinal products (cATMP), tissue engineering products (TEP), and medical devices. The key physico-chemical properties of hydrogels may hinder, mediate, or stimulate therapeutic potentials borne by standardised cellular substrates in regenerative medicine. Parallel to delivery system or scaffold development, hydrogel functionalisation may be advantageous in specific musculoskeletal interventions or topical applications (e.g. viscosupplementation, soft tissue volumetric supplementation, rehabilitation topical preparations). Optimised combination product developmental workflows enable pragmatic regulatory classification of cell-based preparations. Such aspects will be discussed, as well as sustainable transposition to industrialised production settings. Hyaluronan benefits from extensive hindsight in numerous human and veterinary applications, providing a highly versatile backbone for quasi-infinite structural modification and physico-chemical property modulation. This chapter provides an overview of critical product design considerations and possible therapeutic applications of versatile hyaluronan-based preparations intended for cell therapy delivery, combined with optimised autologous or allogeneic therapeutic cell sources (e.g. platelet-rich plasma, stem cells, banked primary foetal progenitors). Particular focus was set on specific parameters directly impacting product potential in terms of clinical translation and effectiveness for topical wound healing or sub-critical volumetric defect correction and repair stimulation in musculoskeletal regenerative medicine applications. |
| format | Online |
| id | doab-20.500.12854ir-122102 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Taylor & Francis |
| publisherStr | Taylor & Francis |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1221022025-03-16T15:23:57Z Chapter 8 Hyaluronan-Based Hydrogels as Functional Vectors for Standardised Therapeutics in Tissue Engineering and Regenerative Medicine Porcello, Alexandre Laurent, Alexis Hirt-Burri, Nathalie Abdel-Sayed, Philippe de Buys Roessingh, Anthony Raffoul, Wassim Jordan, Olivier Allémann, Eric Applegate, Lee Ann Regenerative medicine, Carbon nanotube, Block copolymers, Wound healing, Anticancer therapy, Particles used in imaging Hyaluronan-based hydrogels are optimal candidates when developing novel combined advanced therapy medicinal products (cATMP), tissue engineering products (TEP), and medical devices. The key physico-chemical properties of hydrogels may hinder, mediate, or stimulate therapeutic potentials borne by standardised cellular substrates in regenerative medicine. Parallel to delivery system or scaffold development, hydrogel functionalisation may be advantageous in specific musculoskeletal interventions or topical applications (e.g. viscosupplementation, soft tissue volumetric supplementation, rehabilitation topical preparations). Optimised combination product developmental workflows enable pragmatic regulatory classification of cell-based preparations. Such aspects will be discussed, as well as sustainable transposition to industrialised production settings. Hyaluronan benefits from extensive hindsight in numerous human and veterinary applications, providing a highly versatile backbone for quasi-infinite structural modification and physico-chemical property modulation. This chapter provides an overview of critical product design considerations and possible therapeutic applications of versatile hyaluronan-based preparations intended for cell therapy delivery, combined with optimised autologous or allogeneic therapeutic cell sources (e.g. platelet-rich plasma, stem cells, banked primary foetal progenitors). Particular focus was set on specific parameters directly impacting product potential in terms of clinical translation and effectiveness for topical wound healing or sub-critical volumetric defect correction and repair stimulation in musculoskeletal regenerative medicine applications. 2023-11-17T09:27:57Z 2023-11-17T09:27:57Z 2023-09-27T12:59:58Z 2022 chapter https://library.oapen.org/handle/20.500.12657/76457 9780367721138 9780367721169 https://directory.doabooks.org/handle/20.500.12854/122102 eng open access image/jpeg image/jpeg image/jpeg Attribution 4.0 International Attribution 4.0 International Attribution 4.0 International https://library.oapen.org/bitstream/20.500.12657/76457/1/9781003153504_10.1201_9781003153504-8.pdf https://library.oapen.org/bitstream/20.500.12657/76457/1/9781003153504_10.1201_9781003153504-8.pdf https://library.oapen.org/bitstream/20.500.12657/76457/1/9781003153504_10.1201_9781003153504-8.pdf Taylor & Francis CRC Press 10.1201/9781003153504-8 10.1201/9781003153504-8 fa69b019-f4ee-4979-8d42-c6b6c476b5f0 Nanopharmaceuticals in Regenerative Medicine 9780367721138 9780367721169 CRC Press 31 open access |
| spellingShingle | Regenerative medicine, Carbon nanotube, Block copolymers, Wound healing, Anticancer therapy, Particles used in imaging Porcello, Alexandre Laurent, Alexis Hirt-Burri, Nathalie Abdel-Sayed, Philippe de Buys Roessingh, Anthony Raffoul, Wassim Jordan, Olivier Allémann, Eric Applegate, Lee Ann Chapter 8 Hyaluronan-Based Hydrogels as Functional Vectors for Standardised Therapeutics in Tissue Engineering and Regenerative Medicine |
| title | Chapter 8 Hyaluronan-Based Hydrogels as Functional Vectors for Standardised Therapeutics in Tissue Engineering and Regenerative Medicine |
| title_full | Chapter 8 Hyaluronan-Based Hydrogels as Functional Vectors for Standardised Therapeutics in Tissue Engineering and Regenerative Medicine |
| title_fullStr | Chapter 8 Hyaluronan-Based Hydrogels as Functional Vectors for Standardised Therapeutics in Tissue Engineering and Regenerative Medicine |
| title_full_unstemmed | Chapter 8 Hyaluronan-Based Hydrogels as Functional Vectors for Standardised Therapeutics in Tissue Engineering and Regenerative Medicine |
| title_short | Chapter 8 Hyaluronan-Based Hydrogels as Functional Vectors for Standardised Therapeutics in Tissue Engineering and Regenerative Medicine |
| title_sort | chapter 8 hyaluronan based hydrogels as functional vectors for standardised therapeutics in tissue engineering and regenerative medicine |
| topic | Regenerative medicine, Carbon nanotube, Block copolymers, Wound healing, Anticancer therapy, Particles used in imaging |
| topic_facet | Regenerative medicine, Carbon nanotube, Block copolymers, Wound healing, Anticancer therapy, Particles used in imaging |
| url | https://library.oapen.org/handle/20.500.12657/76457 |
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