Ophthalmic Drug Delivery, 2nd Edition
Research in ophthalmic drug delivery has developed significant advances in the few last years, and efforts have been made to develop more effective topical formulations to increase drug bioavailability, efficiency, and safety. Drug delivery to the posterior segment of the eye remains a great challen...
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| Format: | Online |
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| Langue: | anglais |
| Publié: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Accès en ligne: | ONIX_20231130_9783036587998_9 |
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| _version_ | 1869520177431838720 |
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| collection | Directory of Open Access Books |
| description | Research in ophthalmic drug delivery has developed significant advances in the few last years, and efforts have been made to develop more effective topical formulations to increase drug bioavailability, efficiency, and safety. Drug delivery to the posterior segment of the eye remains a great challenge in the pharmaceutical industry due to the complexity and particularity of the eye's anatomy and physiology. Some advances have been made with the purpose of maintaining constant drug levels in the site of action. The anatomical ocular barriers have a great impact on drug pharmacokinetics and, subsequently, on the pharmacological effect.Despite the increasing interest in efficiently reaching the posterior segment of the eye with reduced adverse effects, there is still a need to expand the knowledge of ocular pharmacokinetics that allow the development of safer and more innovative drug delivery systems. These novel approaches may greatly improve the lives of patients with ocular pathologies. |
| format | Online |
| id | doab-20.500.12854ir-128557 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1285572024-03-31T13:10:24Z Ophthalmic Drug Delivery, 2nd Edition Otero-Espinar, Francisco Javier Ferreiro, Anxo Fernández ocular drug delivery pharmacokinetics tissue isolation rat eye drug concentration method pigment melanin aniridia ataluren ophthalmic solution rare disease stability tacrolimus hydroxypropyl-β-cyclodextrin topical ophthalmic administration eye drops uveitis PET/CT imaging ocular implants electrospinning technique glaucoma sustained drug release poly ε-caprolactone electrospun fibers permeability retina retinal pigment epithelium Ussing chamber intravitreal half-life posterior capsule opacification pathophysiology wound healing lens epithelial cells intraocular lenses experimental models clinical studies gold nanoparticles anterior chamber distribution intracameral injection trabecular meshwork hyaluronic acid liposomes intravitreal ocular drug delivery retinal explants amantadine blood–retinal barrier retinal disease NMDA receptor inner BRB retinal capitally endothelial cells outer BRB retinal pigment epithelial cells transporter rivoceranib drug repositioning microsphere subfoveal choroidal neovascularization macular degeneration endotoxin-induced uveitis interleukins immunosuppressants physicochemical stability container-content interaction leachable compound nanoparticles PLGA lactoferrin nanoprecipitation protein nanocarriers keratoconus corneal ecstatic disorder posterior capsular opacification intraocular lens surface modification photothermal therapy photodynamic therapy micro-pattern anti-biofouling ocular hypertension prostaglandin analogues aqueous solubility chemical stability intraocular pressure cystinosis ophthalmic administration cysteamine compounded formulation PET nanocrystals conjunctivitis besifloxacin Povacoat® fluoroquinolones acanthamoeba keratitis controlled drug delivery contact lens miltefosine thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries Research in ophthalmic drug delivery has developed significant advances in the few last years, and efforts have been made to develop more effective topical formulations to increase drug bioavailability, efficiency, and safety. Drug delivery to the posterior segment of the eye remains a great challenge in the pharmaceutical industry due to the complexity and particularity of the eye's anatomy and physiology. Some advances have been made with the purpose of maintaining constant drug levels in the site of action. The anatomical ocular barriers have a great impact on drug pharmacokinetics and, subsequently, on the pharmacological effect.Despite the increasing interest in efficiently reaching the posterior segment of the eye with reduced adverse effects, there is still a need to expand the knowledge of ocular pharmacokinetics that allow the development of safer and more innovative drug delivery systems. These novel approaches may greatly improve the lives of patients with ocular pathologies. 2023-11-30T20:31:30Z 2023-11-30T20:31:30Z 2023 book ONIX_20231130_9783036587998_9 9783036587998 9783036587981 https://directory.doabooks.org/handle/20.500.12854/128557 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/8004 https://mdpi.com/books/pdfview/book/8004 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-8798-1 10.3390/books978-3-0365-8798-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036587998 9783036587981 316 Basel open access |
| spellingShingle | ocular drug delivery pharmacokinetics tissue isolation rat eye drug concentration method pigment melanin aniridia ataluren ophthalmic solution rare disease stability tacrolimus hydroxypropyl-β-cyclodextrin topical ophthalmic administration eye drops uveitis PET/CT imaging ocular implants electrospinning technique glaucoma sustained drug release poly ε-caprolactone electrospun fibers permeability retina retinal pigment epithelium Ussing chamber intravitreal half-life posterior capsule opacification pathophysiology wound healing lens epithelial cells intraocular lenses experimental models clinical studies gold nanoparticles anterior chamber distribution intracameral injection trabecular meshwork hyaluronic acid liposomes intravitreal ocular drug delivery retinal explants amantadine blood–retinal barrier retinal disease NMDA receptor inner BRB retinal capitally endothelial cells outer BRB retinal pigment epithelial cells transporter rivoceranib drug repositioning microsphere subfoveal choroidal neovascularization macular degeneration endotoxin-induced uveitis interleukins immunosuppressants physicochemical stability container-content interaction leachable compound nanoparticles PLGA lactoferrin nanoprecipitation protein nanocarriers keratoconus corneal ecstatic disorder posterior capsular opacification intraocular lens surface modification photothermal therapy photodynamic therapy micro-pattern anti-biofouling ocular hypertension prostaglandin analogues aqueous solubility chemical stability intraocular pressure cystinosis ophthalmic administration cysteamine compounded formulation PET nanocrystals conjunctivitis besifloxacin Povacoat® fluoroquinolones acanthamoeba keratitis controlled drug delivery contact lens miltefosine thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries Ophthalmic Drug Delivery, 2nd Edition |
| title | Ophthalmic Drug Delivery, 2nd Edition |
| title_full | Ophthalmic Drug Delivery, 2nd Edition |
| title_fullStr | Ophthalmic Drug Delivery, 2nd Edition |
| title_full_unstemmed | Ophthalmic Drug Delivery, 2nd Edition |
| title_short | Ophthalmic Drug Delivery, 2nd Edition |
| title_sort | ophthalmic drug delivery 2nd edition |
| topic | ocular drug delivery pharmacokinetics tissue isolation rat eye drug concentration method pigment melanin aniridia ataluren ophthalmic solution rare disease stability tacrolimus hydroxypropyl-β-cyclodextrin topical ophthalmic administration eye drops uveitis PET/CT imaging ocular implants electrospinning technique glaucoma sustained drug release poly ε-caprolactone electrospun fibers permeability retina retinal pigment epithelium Ussing chamber intravitreal half-life posterior capsule opacification pathophysiology wound healing lens epithelial cells intraocular lenses experimental models clinical studies gold nanoparticles anterior chamber distribution intracameral injection trabecular meshwork hyaluronic acid liposomes intravitreal ocular drug delivery retinal explants amantadine blood–retinal barrier retinal disease NMDA receptor inner BRB retinal capitally endothelial cells outer BRB retinal pigment epithelial cells transporter rivoceranib drug repositioning microsphere subfoveal choroidal neovascularization macular degeneration endotoxin-induced uveitis interleukins immunosuppressants physicochemical stability container-content interaction leachable compound nanoparticles PLGA lactoferrin nanoprecipitation protein nanocarriers keratoconus corneal ecstatic disorder posterior capsular opacification intraocular lens surface modification photothermal therapy photodynamic therapy micro-pattern anti-biofouling ocular hypertension prostaglandin analogues aqueous solubility chemical stability intraocular pressure cystinosis ophthalmic administration cysteamine compounded formulation PET nanocrystals conjunctivitis besifloxacin Povacoat® fluoroquinolones acanthamoeba keratitis controlled drug delivery contact lens miltefosine thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries |
| topic_facet | ocular drug delivery pharmacokinetics tissue isolation rat eye drug concentration method pigment melanin aniridia ataluren ophthalmic solution rare disease stability tacrolimus hydroxypropyl-β-cyclodextrin topical ophthalmic administration eye drops uveitis PET/CT imaging ocular implants electrospinning technique glaucoma sustained drug release poly ε-caprolactone electrospun fibers permeability retina retinal pigment epithelium Ussing chamber intravitreal half-life posterior capsule opacification pathophysiology wound healing lens epithelial cells intraocular lenses experimental models clinical studies gold nanoparticles anterior chamber distribution intracameral injection trabecular meshwork hyaluronic acid liposomes intravitreal ocular drug delivery retinal explants amantadine blood–retinal barrier retinal disease NMDA receptor inner BRB retinal capitally endothelial cells outer BRB retinal pigment epithelial cells transporter rivoceranib drug repositioning microsphere subfoveal choroidal neovascularization macular degeneration endotoxin-induced uveitis interleukins immunosuppressants physicochemical stability container-content interaction leachable compound nanoparticles PLGA lactoferrin nanoprecipitation protein nanocarriers keratoconus corneal ecstatic disorder posterior capsular opacification intraocular lens surface modification photothermal therapy photodynamic therapy micro-pattern anti-biofouling ocular hypertension prostaglandin analogues aqueous solubility chemical stability intraocular pressure cystinosis ophthalmic administration cysteamine compounded formulation PET nanocrystals conjunctivitis besifloxacin Povacoat® fluoroquinolones acanthamoeba keratitis controlled drug delivery contact lens miltefosine thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries |
| url | ONIX_20231130_9783036587998_9 |