Physics of Protein Folding, Misfolding, and Intrinsic Disorder: A Themed Issue in Honour of Professor Vladimir Uversky on the Occasion of His 60th Birthday
This Special Issue of Biomolecules, “Physics of Protein Folding, Misfolding, and Intrinsic Disorder: A Themed Issue in Honour of Professor Vladimir Uversky on the Occasion of His 60th Birthday”, is a dedication to one of the discoverers of IDPs. This collection is a small token of the respect, admir...
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Rochtain ar líne: | ONIX_20231130_9783036591124_61 |
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Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
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| collection | Directory of Open Access Books |
| description | This Special Issue of Biomolecules, “Physics of Protein Folding, Misfolding, and Intrinsic Disorder: A Themed Issue in Honour of Professor Vladimir Uversky on the Occasion of His 60th Birthday”, is a dedication to one of the discoverers of IDPs. This collection is a small token of the respect, admiration, and affection the contributors have for Prof. Vladimir (Volodya) Uversky. It is also a celebration of his illustrious career, and his accomplishments, and contributions to the IDP field that have inspired so many minds worldwide. This Special Issue presents the state of the art as it emerges from the contribution of the community of IDP researchers (IDPers), who have responded to the invitation to give credit to the pioneering work of Prof. Vladimir Uversky aimed at defining the class of disordered proteins and at promoting the attention of scientists toward the existence of “non-globular proteins”. The papers in this collection show the advancement of our knowledge through the application of an integrative structural approach and witnesses at the same time the interest of the IDPer community toward new concepts (i.e., liquid-liquid phase separation) and new methodological frontiers (i.e., the application of machine learning and artificial intelligence to disorder prediction and modelling). |
| format | Online |
| id | doab-20.500.12854ir-128609 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1286092024-03-28T03:33:46Z Physics of Protein Folding, Misfolding, and Intrinsic Disorder: A Themed Issue in Honour of Professor Vladimir Uversky on the Occasion of His 60th Birthday Kulkarni, Prakash Brocca, Stefania Dunker, Keith Longhi, Sonia charge clustering polyelectrolytes average shape of conformational ensembles charged-residue patterning hydrodynamic radius solvent-accessible surface area proline content conformational compactness ellipsoid model intrinsically disordered proteins (IDPs) intrinsically disordered protein regions (IDRs) LC–MS/MS IUPred analysis Ostrinia nubilalis cold hardiness intrinsic disorder intrinsically disordered proteins intrinsic disordered regions disorder scale disorder propensity amino acids amino acid bias predictive performance disorder prediction SARS-CoV-2 COVID-19 IDP RNA NMR pH liquid-liquid phase separation protein solubility protein disorder mutations bioinformatics kinetics fluorescence site-directed mutagenesis protein–protein interactions SH2 domains Crkl Paxillin Calvin-Benson-Bassham cycle conditionally disordered protein history of modern science metabolism regulation moonlighting protein protein-protein interaction biomolecular condensates machine learning predictor physical interactions phase separation liquid–liquid phase separation biomineralization calcium carbonate otoliths nucleation pathways nickel intrinsically disordered regions lung cancer nmr isothermal titration calorimetry circular dichroism light scattering Dss1 intrinsically disordered protein IDPs molecular dynamics sequence composition SAXS membrane-less organelles stress long foldable segments pyHCA soluble domains protein sequence conditional order hidden order dark proteomes intrinsically disordered domains coexistence line tumor suppressor p53 intramolecular interaction salt-dependent binding affinity counterion condensation theory DNA binding fluorescence anisotropy van’t Hoff protein purification affinity chromatography Tau androgen receptor (AF1) isoform large-scale analysis protein structure AlphaFold canonical protein alpha-synuclein membrane synaptic vesicle synapsin Parkinson’s Myc drug targets SLiM small-molecule inhibitors glutamate receptor discrete molecular dynamics single molecule fluorescence integrative structural biology unfolded unstructured flexible protein function polymer physics percolation entanglement topology polymer rheology D/E repeats K/R repeats molecular dynamics simulations hub proteins multivalency transcription factor linker length heterogeneity dimers duplexes coarse-grained simulation molecular mass LLPS stability FUS n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences This Special Issue of Biomolecules, “Physics of Protein Folding, Misfolding, and Intrinsic Disorder: A Themed Issue in Honour of Professor Vladimir Uversky on the Occasion of His 60th Birthday”, is a dedication to one of the discoverers of IDPs. This collection is a small token of the respect, admiration, and affection the contributors have for Prof. Vladimir (Volodya) Uversky. It is also a celebration of his illustrious career, and his accomplishments, and contributions to the IDP field that have inspired so many minds worldwide. This Special Issue presents the state of the art as it emerges from the contribution of the community of IDP researchers (IDPers), who have responded to the invitation to give credit to the pioneering work of Prof. Vladimir Uversky aimed at defining the class of disordered proteins and at promoting the attention of scientists toward the existence of “non-globular proteins”. The papers in this collection show the advancement of our knowledge through the application of an integrative structural approach and witnesses at the same time the interest of the IDPer community toward new concepts (i.e., liquid-liquid phase separation) and new methodological frontiers (i.e., the application of machine learning and artificial intelligence to disorder prediction and modelling). 2023-11-30T20:36:01Z 2023-11-30T20:36:01Z 2023 book ONIX_20231130_9783036591124_61 9783036591124 9783036591131 https://directory.doabooks.org/handle/20.500.12854/128609 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/8061 https://mdpi.com/books/pdfview/book/8061 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-9113-1 10.3390/books978-3-0365-9113-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036591124 9783036591131 486 Basel open access |
| spellingShingle | charge clustering polyelectrolytes average shape of conformational ensembles charged-residue patterning hydrodynamic radius solvent-accessible surface area proline content conformational compactness ellipsoid model intrinsically disordered proteins (IDPs) intrinsically disordered protein regions (IDRs) LC–MS/MS IUPred analysis Ostrinia nubilalis cold hardiness intrinsic disorder intrinsically disordered proteins intrinsic disordered regions disorder scale disorder propensity amino acids amino acid bias predictive performance disorder prediction SARS-CoV-2 COVID-19 IDP RNA NMR pH liquid-liquid phase separation protein solubility protein disorder mutations bioinformatics kinetics fluorescence site-directed mutagenesis protein–protein interactions SH2 domains Crkl Paxillin Calvin-Benson-Bassham cycle conditionally disordered protein history of modern science metabolism regulation moonlighting protein protein-protein interaction biomolecular condensates machine learning predictor physical interactions phase separation liquid–liquid phase separation biomineralization calcium carbonate otoliths nucleation pathways nickel intrinsically disordered regions lung cancer nmr isothermal titration calorimetry circular dichroism light scattering Dss1 intrinsically disordered protein IDPs molecular dynamics sequence composition SAXS membrane-less organelles stress long foldable segments pyHCA soluble domains protein sequence conditional order hidden order dark proteomes intrinsically disordered domains coexistence line tumor suppressor p53 intramolecular interaction salt-dependent binding affinity counterion condensation theory DNA binding fluorescence anisotropy van’t Hoff protein purification affinity chromatography Tau androgen receptor (AF1) isoform large-scale analysis protein structure AlphaFold canonical protein alpha-synuclein membrane synaptic vesicle synapsin Parkinson’s Myc drug targets SLiM small-molecule inhibitors glutamate receptor discrete molecular dynamics single molecule fluorescence integrative structural biology unfolded unstructured flexible protein function polymer physics percolation entanglement topology polymer rheology D/E repeats K/R repeats molecular dynamics simulations hub proteins multivalency transcription factor linker length heterogeneity dimers duplexes coarse-grained simulation molecular mass LLPS stability FUS n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Physics of Protein Folding, Misfolding, and Intrinsic Disorder: A Themed Issue in Honour of Professor Vladimir Uversky on the Occasion of His 60th Birthday |
| title | Physics of Protein Folding, Misfolding, and Intrinsic Disorder: A Themed Issue in Honour of Professor Vladimir Uversky on the Occasion of His 60th Birthday |
| title_full | Physics of Protein Folding, Misfolding, and Intrinsic Disorder: A Themed Issue in Honour of Professor Vladimir Uversky on the Occasion of His 60th Birthday |
| title_fullStr | Physics of Protein Folding, Misfolding, and Intrinsic Disorder: A Themed Issue in Honour of Professor Vladimir Uversky on the Occasion of His 60th Birthday |
| title_full_unstemmed | Physics of Protein Folding, Misfolding, and Intrinsic Disorder: A Themed Issue in Honour of Professor Vladimir Uversky on the Occasion of His 60th Birthday |
| title_short | Physics of Protein Folding, Misfolding, and Intrinsic Disorder: A Themed Issue in Honour of Professor Vladimir Uversky on the Occasion of His 60th Birthday |
| title_sort | physics of protein folding misfolding and intrinsic disorder a themed issue in honour of professor vladimir uversky on the occasion of his 60th birthday |
| topic | charge clustering polyelectrolytes average shape of conformational ensembles charged-residue patterning hydrodynamic radius solvent-accessible surface area proline content conformational compactness ellipsoid model intrinsically disordered proteins (IDPs) intrinsically disordered protein regions (IDRs) LC–MS/MS IUPred analysis Ostrinia nubilalis cold hardiness intrinsic disorder intrinsically disordered proteins intrinsic disordered regions disorder scale disorder propensity amino acids amino acid bias predictive performance disorder prediction SARS-CoV-2 COVID-19 IDP RNA NMR pH liquid-liquid phase separation protein solubility protein disorder mutations bioinformatics kinetics fluorescence site-directed mutagenesis protein–protein interactions SH2 domains Crkl Paxillin Calvin-Benson-Bassham cycle conditionally disordered protein history of modern science metabolism regulation moonlighting protein protein-protein interaction biomolecular condensates machine learning predictor physical interactions phase separation liquid–liquid phase separation biomineralization calcium carbonate otoliths nucleation pathways nickel intrinsically disordered regions lung cancer nmr isothermal titration calorimetry circular dichroism light scattering Dss1 intrinsically disordered protein IDPs molecular dynamics sequence composition SAXS membrane-less organelles stress long foldable segments pyHCA soluble domains protein sequence conditional order hidden order dark proteomes intrinsically disordered domains coexistence line tumor suppressor p53 intramolecular interaction salt-dependent binding affinity counterion condensation theory DNA binding fluorescence anisotropy van’t Hoff protein purification affinity chromatography Tau androgen receptor (AF1) isoform large-scale analysis protein structure AlphaFold canonical protein alpha-synuclein membrane synaptic vesicle synapsin Parkinson’s Myc drug targets SLiM small-molecule inhibitors glutamate receptor discrete molecular dynamics single molecule fluorescence integrative structural biology unfolded unstructured flexible protein function polymer physics percolation entanglement topology polymer rheology D/E repeats K/R repeats molecular dynamics simulations hub proteins multivalency transcription factor linker length heterogeneity dimers duplexes coarse-grained simulation molecular mass LLPS stability FUS n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | charge clustering polyelectrolytes average shape of conformational ensembles charged-residue patterning hydrodynamic radius solvent-accessible surface area proline content conformational compactness ellipsoid model intrinsically disordered proteins (IDPs) intrinsically disordered protein regions (IDRs) LC–MS/MS IUPred analysis Ostrinia nubilalis cold hardiness intrinsic disorder intrinsically disordered proteins intrinsic disordered regions disorder scale disorder propensity amino acids amino acid bias predictive performance disorder prediction SARS-CoV-2 COVID-19 IDP RNA NMR pH liquid-liquid phase separation protein solubility protein disorder mutations bioinformatics kinetics fluorescence site-directed mutagenesis protein–protein interactions SH2 domains Crkl Paxillin Calvin-Benson-Bassham cycle conditionally disordered protein history of modern science metabolism regulation moonlighting protein protein-protein interaction biomolecular condensates machine learning predictor physical interactions phase separation liquid–liquid phase separation biomineralization calcium carbonate otoliths nucleation pathways nickel intrinsically disordered regions lung cancer nmr isothermal titration calorimetry circular dichroism light scattering Dss1 intrinsically disordered protein IDPs molecular dynamics sequence composition SAXS membrane-less organelles stress long foldable segments pyHCA soluble domains protein sequence conditional order hidden order dark proteomes intrinsically disordered domains coexistence line tumor suppressor p53 intramolecular interaction salt-dependent binding affinity counterion condensation theory DNA binding fluorescence anisotropy van’t Hoff protein purification affinity chromatography Tau androgen receptor (AF1) isoform large-scale analysis protein structure AlphaFold canonical protein alpha-synuclein membrane synaptic vesicle synapsin Parkinson’s Myc drug targets SLiM small-molecule inhibitors glutamate receptor discrete molecular dynamics single molecule fluorescence integrative structural biology unfolded unstructured flexible protein function polymer physics percolation entanglement topology polymer rheology D/E repeats K/R repeats molecular dynamics simulations hub proteins multivalency transcription factor linker length heterogeneity dimers duplexes coarse-grained simulation molecular mass LLPS stability FUS n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20231130_9783036591124_61 |