Recent Advances in Understanding of the Role of Synuclein Family Members in Health and Disease
In this Special Issue, we have compiled data and opinions from leading scientists to demonstrate the recent advances in the study of function and dysfunction of synucleins. These proteins are involved in multiple normal and pathological molecular processes and consequently have various effects on ce...
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| Aineistotyyppi: | Online |
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| Kieli: | englanti |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Aiheet: | |
| Linkit: | ONIX_20231130_9783036589381_131 |
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| collection | Directory of Open Access Books |
| description | In this Special Issue, we have compiled data and opinions from leading scientists to demonstrate the recent advances in the study of function and dysfunction of synucleins. These proteins are involved in multiple normal and pathological molecular processes and consequently have various effects on cell biology of the nervous system. Three members of the synuclein family share many structural properties and have an overlapping pattern of expression and intracellular distribution in the developing and adult nervous system, which point to functional redundancy within the family. However, each synuclein has its own functions which are not shared with the two other family members, and there are certain cellular mechanisms and pathways in which these functions could be antagonistic rather than synergistic. |
| format | Online |
| id | doab-20.500.12854ir-128679 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
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| spelling | doab-20.500.12854ir-1286792024-03-31T13:08:32Z Recent Advances in Understanding of the Role of Synuclein Family Members in Health and Disease Ninkina, Natalia prenatal alcohol exposure synucleins alcohol consumption free-choice hippocampus midbrain mRNA expression α-synuclein rats dopaminergic neuron MPTP knockout mice Parkinson’s disease alpha-synuclein SH-SY5Y hiPSCs organoid aggregation synucleinopathy blood–brain barrier microglia astrocytes overexpression mutation Lewy body synucleinopathies multiple system atrophy dementia with Lewy bodies deep brain stimulation focused ultrasound gene therapy surgical techniques dopamine electroencephalogram frequency spectrum α-, β- and γ-synuclein epigenetic protein aggregation SNARE-complex protein trafficking phytochemicals methylation histones γ-synuclein autoantibodies glaucoma α2-macroglobulin tear fluid intraocular pressure SARS-CoV-2 spike RBD domain amyloid aggregation post-COVID-19 neurodegeneration SARS-CoV-2 vaccine depression serotonin raphe nuclei Lewy bodies diseases E46K-SNCA cognition nonmotor clustering analysis multimodal MRI n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences In this Special Issue, we have compiled data and opinions from leading scientists to demonstrate the recent advances in the study of function and dysfunction of synucleins. These proteins are involved in multiple normal and pathological molecular processes and consequently have various effects on cell biology of the nervous system. Three members of the synuclein family share many structural properties and have an overlapping pattern of expression and intracellular distribution in the developing and adult nervous system, which point to functional redundancy within the family. However, each synuclein has its own functions which are not shared with the two other family members, and there are certain cellular mechanisms and pathways in which these functions could be antagonistic rather than synergistic. 2023-11-30T20:43:03Z 2023-11-30T20:43:03Z 2023 book ONIX_20231130_9783036589381_131 9783036589381 9783036589398 https://directory.doabooks.org/handle/20.500.12854/128679 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/8141 https://mdpi.com/books/pdfview/book/8141 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-8939-8 10.3390/books978-3-0365-8939-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036589381 9783036589398 188 Basel open access |
| spellingShingle | prenatal alcohol exposure synucleins alcohol consumption free-choice hippocampus midbrain mRNA expression α-synuclein rats dopaminergic neuron MPTP knockout mice Parkinson’s disease alpha-synuclein SH-SY5Y hiPSCs organoid aggregation synucleinopathy blood–brain barrier microglia astrocytes overexpression mutation Lewy body synucleinopathies multiple system atrophy dementia with Lewy bodies deep brain stimulation focused ultrasound gene therapy surgical techniques dopamine electroencephalogram frequency spectrum α-, β- and γ-synuclein epigenetic protein aggregation SNARE-complex protein trafficking phytochemicals methylation histones γ-synuclein autoantibodies glaucoma α2-macroglobulin tear fluid intraocular pressure SARS-CoV-2 spike RBD domain amyloid aggregation post-COVID-19 neurodegeneration SARS-CoV-2 vaccine depression serotonin raphe nuclei Lewy bodies diseases E46K-SNCA cognition nonmotor clustering analysis multimodal MRI n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Recent Advances in Understanding of the Role of Synuclein Family Members in Health and Disease |
| title | Recent Advances in Understanding of the Role of Synuclein Family Members in Health and Disease |
| title_full | Recent Advances in Understanding of the Role of Synuclein Family Members in Health and Disease |
| title_fullStr | Recent Advances in Understanding of the Role of Synuclein Family Members in Health and Disease |
| title_full_unstemmed | Recent Advances in Understanding of the Role of Synuclein Family Members in Health and Disease |
| title_short | Recent Advances in Understanding of the Role of Synuclein Family Members in Health and Disease |
| title_sort | recent advances in understanding of the role of synuclein family members in health and disease |
| topic | prenatal alcohol exposure synucleins alcohol consumption free-choice hippocampus midbrain mRNA expression α-synuclein rats dopaminergic neuron MPTP knockout mice Parkinson’s disease alpha-synuclein SH-SY5Y hiPSCs organoid aggregation synucleinopathy blood–brain barrier microglia astrocytes overexpression mutation Lewy body synucleinopathies multiple system atrophy dementia with Lewy bodies deep brain stimulation focused ultrasound gene therapy surgical techniques dopamine electroencephalogram frequency spectrum α-, β- and γ-synuclein epigenetic protein aggregation SNARE-complex protein trafficking phytochemicals methylation histones γ-synuclein autoantibodies glaucoma α2-macroglobulin tear fluid intraocular pressure SARS-CoV-2 spike RBD domain amyloid aggregation post-COVID-19 neurodegeneration SARS-CoV-2 vaccine depression serotonin raphe nuclei Lewy bodies diseases E46K-SNCA cognition nonmotor clustering analysis multimodal MRI n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | prenatal alcohol exposure synucleins alcohol consumption free-choice hippocampus midbrain mRNA expression α-synuclein rats dopaminergic neuron MPTP knockout mice Parkinson’s disease alpha-synuclein SH-SY5Y hiPSCs organoid aggregation synucleinopathy blood–brain barrier microglia astrocytes overexpression mutation Lewy body synucleinopathies multiple system atrophy dementia with Lewy bodies deep brain stimulation focused ultrasound gene therapy surgical techniques dopamine electroencephalogram frequency spectrum α-, β- and γ-synuclein epigenetic protein aggregation SNARE-complex protein trafficking phytochemicals methylation histones γ-synuclein autoantibodies glaucoma α2-macroglobulin tear fluid intraocular pressure SARS-CoV-2 spike RBD domain amyloid aggregation post-COVID-19 neurodegeneration SARS-CoV-2 vaccine depression serotonin raphe nuclei Lewy bodies diseases E46K-SNCA cognition nonmotor clustering analysis multimodal MRI n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | ONIX_20231130_9783036589381_131 |