Omics Approaches to Immune-Mediated Inflammatory Diseases: Towards Novel Biomarkers and Potential Therapeutic Targets
Chronic immune-mediated inflammatory diseases (IMIDs), usually accompanied by cardiovascular disease and neoplasias, are now prevailed worldwide. The limited efficacy of current therapeutics and a proportion of non-responders are linked to missing aspects in their pathophysiology at the molecular an...
Wedi'i Gadw mewn:
| Fformat: | Online |
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| Iaith: | Saesneg |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Pynciau: | |
| Mynediad Ar-lein: | ONIX_20231130_9783036592763_150 |
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Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
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| _version_ | 1869523731018153984 |
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| collection | Directory of Open Access Books |
| description | Chronic immune-mediated inflammatory diseases (IMIDs), usually accompanied by cardiovascular disease and neoplasias, are now prevailed worldwide. The limited efficacy of current therapeutics and a proportion of non-responders are linked to missing aspects in their pathophysiology at the molecular and cellular levels. High-throughput single- and multi-omics approaches and their combinations are expected to pinpoint the key players underlying IMIDs’ establishment and/or progression, thus suggesting potential therapeutic targets and biomarkers. This Reprint gathered 13 papers presenting recent relevant data related to the assessment of CVD risk in RA, tailored therapeutics in RA-interstitial lung disease, IgG4-related RA, and Sjögren’s syndrome, enabling early identification of PsA and improving outcomes in patients’ with psoriasis. Also, novel non-invasive biomarkers for endoscopic activity and mucosal healing in ulcerative colitis, IBD, and cell-death-associated inflammatory syndromes are proposed. Moreover, a certain subset of telocytes is suggested as the pilot governor of epithelial behavior in preneoplastic gastric lesions, a newer member of IL-1 family, as it is a critical partner in lung adenocarcinoma, while distinct transcriptomic signatures and pathway profiles in human melanocytes corresponding to different Staphylococcal superantigenic enterotoxins are possible targets for therapeutic intervention in cases of toxic shocks. Lastly, Tregs- and dendritic cell-based IMID biomarkers are recommended to enable at more efficient, personalized, and precise treatment strategies. |
| format | Online |
| id | doab-20.500.12854ir-128698 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1286982024-03-31T13:10:01Z Omics Approaches to Immune-Mediated Inflammatory Diseases: Towards Novel Biomarkers and Potential Therapeutic Targets Christodoulou, Maria-Ioanna arthritis rheumatoid immunoglobulin G immune system inflammation proteins proteomics rheumatoid arthritis periodontal disease cardiovascular disease biomarker ulcerative colitis gelsolin mucosal healing interstitial lung disease biomarkers treatment superantigens gene expression transcriptional dynamics staphylococcal enterotoxins SEB SEA TSST-1 toxins biological networks clustering functional pathways time–course analysis cDNA microarray human melanocytes cell death apoptosis necroptosis pyroptosis ubiquitin LUBAC OTULIN A20 autoimmunity human genetics epigenetics endoscopy imaging laboratory testing Sjogren’s syndrome patient stratification clinical relevance multi-omics psoriasis methylation histone ncRNAs immune-mediated inflammatory disorders autoimmune diseases immune regulation dendritic cells regulatory T cells omics therapeutic targeting chronic inflammation psoriatic diseases psoriatic arthritis data integration interleukin (IL-)37 lung adenocarcinoma survival infiltration rates FoxL1+-telocytes epithelial–mesenchymal interaction BMP signaling extracellular matrix mechanical microenvironment matrisome thema EDItEUR::M Medicine and Nursing Chronic immune-mediated inflammatory diseases (IMIDs), usually accompanied by cardiovascular disease and neoplasias, are now prevailed worldwide. The limited efficacy of current therapeutics and a proportion of non-responders are linked to missing aspects in their pathophysiology at the molecular and cellular levels. High-throughput single- and multi-omics approaches and their combinations are expected to pinpoint the key players underlying IMIDs’ establishment and/or progression, thus suggesting potential therapeutic targets and biomarkers. This Reprint gathered 13 papers presenting recent relevant data related to the assessment of CVD risk in RA, tailored therapeutics in RA-interstitial lung disease, IgG4-related RA, and Sjögren’s syndrome, enabling early identification of PsA and improving outcomes in patients’ with psoriasis. Also, novel non-invasive biomarkers for endoscopic activity and mucosal healing in ulcerative colitis, IBD, and cell-death-associated inflammatory syndromes are proposed. Moreover, a certain subset of telocytes is suggested as the pilot governor of epithelial behavior in preneoplastic gastric lesions, a newer member of IL-1 family, as it is a critical partner in lung adenocarcinoma, while distinct transcriptomic signatures and pathway profiles in human melanocytes corresponding to different Staphylococcal superantigenic enterotoxins are possible targets for therapeutic intervention in cases of toxic shocks. Lastly, Tregs- and dendritic cell-based IMID biomarkers are recommended to enable at more efficient, personalized, and precise treatment strategies. 2023-11-30T20:44:29Z 2023-11-30T20:44:29Z 2023 book ONIX_20231130_9783036592763_150 9783036592763 9783036592770 https://directory.doabooks.org/handle/20.500.12854/128698 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/8162 https://mdpi.com/books/pdfview/book/8162 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-9277-0 10.3390/books978-3-0365-9277-0 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036592763 9783036592770 246 Basel open access |
| spellingShingle | arthritis rheumatoid immunoglobulin G immune system inflammation proteins proteomics rheumatoid arthritis periodontal disease cardiovascular disease biomarker ulcerative colitis gelsolin mucosal healing interstitial lung disease biomarkers treatment superantigens gene expression transcriptional dynamics staphylococcal enterotoxins SEB SEA TSST-1 toxins biological networks clustering functional pathways time–course analysis cDNA microarray human melanocytes cell death apoptosis necroptosis pyroptosis ubiquitin LUBAC OTULIN A20 autoimmunity human genetics epigenetics endoscopy imaging laboratory testing Sjogren’s syndrome patient stratification clinical relevance multi-omics psoriasis methylation histone ncRNAs immune-mediated inflammatory disorders autoimmune diseases immune regulation dendritic cells regulatory T cells omics therapeutic targeting chronic inflammation psoriatic diseases psoriatic arthritis data integration interleukin (IL-)37 lung adenocarcinoma survival infiltration rates FoxL1+-telocytes epithelial–mesenchymal interaction BMP signaling extracellular matrix mechanical microenvironment matrisome thema EDItEUR::M Medicine and Nursing Omics Approaches to Immune-Mediated Inflammatory Diseases: Towards Novel Biomarkers and Potential Therapeutic Targets |
| title | Omics Approaches to Immune-Mediated Inflammatory Diseases: Towards Novel Biomarkers and Potential Therapeutic Targets |
| title_full | Omics Approaches to Immune-Mediated Inflammatory Diseases: Towards Novel Biomarkers and Potential Therapeutic Targets |
| title_fullStr | Omics Approaches to Immune-Mediated Inflammatory Diseases: Towards Novel Biomarkers and Potential Therapeutic Targets |
| title_full_unstemmed | Omics Approaches to Immune-Mediated Inflammatory Diseases: Towards Novel Biomarkers and Potential Therapeutic Targets |
| title_short | Omics Approaches to Immune-Mediated Inflammatory Diseases: Towards Novel Biomarkers and Potential Therapeutic Targets |
| title_sort | omics approaches to immune mediated inflammatory diseases towards novel biomarkers and potential therapeutic targets |
| topic | arthritis rheumatoid immunoglobulin G immune system inflammation proteins proteomics rheumatoid arthritis periodontal disease cardiovascular disease biomarker ulcerative colitis gelsolin mucosal healing interstitial lung disease biomarkers treatment superantigens gene expression transcriptional dynamics staphylococcal enterotoxins SEB SEA TSST-1 toxins biological networks clustering functional pathways time–course analysis cDNA microarray human melanocytes cell death apoptosis necroptosis pyroptosis ubiquitin LUBAC OTULIN A20 autoimmunity human genetics epigenetics endoscopy imaging laboratory testing Sjogren’s syndrome patient stratification clinical relevance multi-omics psoriasis methylation histone ncRNAs immune-mediated inflammatory disorders autoimmune diseases immune regulation dendritic cells regulatory T cells omics therapeutic targeting chronic inflammation psoriatic diseases psoriatic arthritis data integration interleukin (IL-)37 lung adenocarcinoma survival infiltration rates FoxL1+-telocytes epithelial–mesenchymal interaction BMP signaling extracellular matrix mechanical microenvironment matrisome thema EDItEUR::M Medicine and Nursing |
| topic_facet | arthritis rheumatoid immunoglobulin G immune system inflammation proteins proteomics rheumatoid arthritis periodontal disease cardiovascular disease biomarker ulcerative colitis gelsolin mucosal healing interstitial lung disease biomarkers treatment superantigens gene expression transcriptional dynamics staphylococcal enterotoxins SEB SEA TSST-1 toxins biological networks clustering functional pathways time–course analysis cDNA microarray human melanocytes cell death apoptosis necroptosis pyroptosis ubiquitin LUBAC OTULIN A20 autoimmunity human genetics epigenetics endoscopy imaging laboratory testing Sjogren’s syndrome patient stratification clinical relevance multi-omics psoriasis methylation histone ncRNAs immune-mediated inflammatory disorders autoimmune diseases immune regulation dendritic cells regulatory T cells omics therapeutic targeting chronic inflammation psoriatic diseases psoriatic arthritis data integration interleukin (IL-)37 lung adenocarcinoma survival infiltration rates FoxL1+-telocytes epithelial–mesenchymal interaction BMP signaling extracellular matrix mechanical microenvironment matrisome thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20231130_9783036592763_150 |