Diagnosis, Treatment, and Management of COPD and Asthma
Chronic obstructive pulmonary disease (COPD) is a disorder characterized by airflow limitation and is one of the major causes of mortality and morbidity across the globe. Although several guidelines have been published over the past three decades, they were generated in response to the fact that COP...
Gardado en:
| Formato: | Online |
|---|---|
| Idioma: | inglés |
| Publicado: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
|
| Subjects: | |
| Acceso en liña: | ONIX_20231130_9783036589657_165 |
| Tags: |
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
|
| _version_ | 1869529332232224768 |
|---|---|
| collection | Directory of Open Access Books |
| description | Chronic obstructive pulmonary disease (COPD) is a disorder characterized by airflow limitation and is one of the major causes of mortality and morbidity across the globe. Although several guidelines have been published over the past three decades, they were generated in response to the fact that COPD is a major cause of mortality and morbidity and remains an important social problem. In the 20th century, forced expiratory volume in one second (FEV1) was the single most important measure in patients with COPD from discriminative, evaluative, and predictive standpoints. We found that dyspnea is a better mortality predictor than FEV1 in 2002 and exercise capacity in 2003. Subsequently, it has become apparent that physical activity is more predictive of mortality. Furthermore, we have recently developed the tendency to use the reduction of the future risk of exacerbation as the endpoint of relatively large-scale clinical trials rather than the improvement of FEV1. Many researchers have continued to seek better outcome markers and have also discussed what should be used as primary or secondary endpoints in clinical trials in subjects with COPD. We have undoubtedly made great progress but still have a lot of work to do for the best interests of patients. |
| format | Online |
| id | doab-20.500.12854ir-128713 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1287132024-03-31T13:10:07Z Diagnosis, Treatment, and Management of COPD and Asthma Nishimura, Koichi COPD biomass-burning HHIP sputum supernatant lung function indoor pollution chronic obstructive pulmonary disease cytokines systemic inflammation clusters adenosine triphosphate heat shock protein 70 lung cancer saliva biochemistry diagnostics prognosis 6MWT STST exercise capacity oxygen desaturation acidosis breathing cardiopulmonary exercise testing dynamic hyperinflation muscle ventilation inhaled corticosteroids (ICS) chronic obstructive pulmonary disease (COPD) blood eosinophil count (BEC) eosinophil the Global Initiative for Chronic Obstructive Lung Disease (GOLD) acute exacerbation of COPD (AECOPD) SERS multivariate analysis spirometry lower limit of normal underdiagnosis early detection app-based spirometer asthma–COPD overlap asthma fractional exhaled nitric oxide immunoglobulin E COPD guideline Asia respiratory pathophysiology bronchodilator reversibility biomarker treatment response the Brief Fatigue Inventory (BFI) the revised Short–Form McGill Pain Questionnaire 2 (SF-MPQ-2) the Kihon Checklist fatigue pain respiratory diseases inflammatory markers neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) telemedicine telehealth telemonitoring acute exacerbation COPD diagnosis prevention biomarkers biologics eosinophils inflammation neutrophils treatment n/a thema EDItEUR::M Medicine and Nursing Chronic obstructive pulmonary disease (COPD) is a disorder characterized by airflow limitation and is one of the major causes of mortality and morbidity across the globe. Although several guidelines have been published over the past three decades, they were generated in response to the fact that COPD is a major cause of mortality and morbidity and remains an important social problem. In the 20th century, forced expiratory volume in one second (FEV1) was the single most important measure in patients with COPD from discriminative, evaluative, and predictive standpoints. We found that dyspnea is a better mortality predictor than FEV1 in 2002 and exercise capacity in 2003. Subsequently, it has become apparent that physical activity is more predictive of mortality. Furthermore, we have recently developed the tendency to use the reduction of the future risk of exacerbation as the endpoint of relatively large-scale clinical trials rather than the improvement of FEV1. Many researchers have continued to seek better outcome markers and have also discussed what should be used as primary or secondary endpoints in clinical trials in subjects with COPD. We have undoubtedly made great progress but still have a lot of work to do for the best interests of patients. 2023-11-30T20:45:49Z 2023-11-30T20:45:49Z 2023 book ONIX_20231130_9783036589657_165 9783036589657 9783036589640 https://directory.doabooks.org/handle/20.500.12854/128713 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/8177 https://mdpi.com/books/pdfview/book/8177 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-8964-0 10.3390/books978-3-0365-8964-0 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036589657 9783036589640 286 Basel open access |
| spellingShingle | COPD biomass-burning HHIP sputum supernatant lung function indoor pollution chronic obstructive pulmonary disease cytokines systemic inflammation clusters adenosine triphosphate heat shock protein 70 lung cancer saliva biochemistry diagnostics prognosis 6MWT STST exercise capacity oxygen desaturation acidosis breathing cardiopulmonary exercise testing dynamic hyperinflation muscle ventilation inhaled corticosteroids (ICS) chronic obstructive pulmonary disease (COPD) blood eosinophil count (BEC) eosinophil the Global Initiative for Chronic Obstructive Lung Disease (GOLD) acute exacerbation of COPD (AECOPD) SERS multivariate analysis spirometry lower limit of normal underdiagnosis early detection app-based spirometer asthma–COPD overlap asthma fractional exhaled nitric oxide immunoglobulin E COPD guideline Asia respiratory pathophysiology bronchodilator reversibility biomarker treatment response the Brief Fatigue Inventory (BFI) the revised Short–Form McGill Pain Questionnaire 2 (SF-MPQ-2) the Kihon Checklist fatigue pain respiratory diseases inflammatory markers neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) telemedicine telehealth telemonitoring acute exacerbation COPD diagnosis prevention biomarkers biologics eosinophils inflammation neutrophils treatment n/a thema EDItEUR::M Medicine and Nursing Diagnosis, Treatment, and Management of COPD and Asthma |
| title | Diagnosis, Treatment, and Management of COPD and Asthma |
| title_full | Diagnosis, Treatment, and Management of COPD and Asthma |
| title_fullStr | Diagnosis, Treatment, and Management of COPD and Asthma |
| title_full_unstemmed | Diagnosis, Treatment, and Management of COPD and Asthma |
| title_short | Diagnosis, Treatment, and Management of COPD and Asthma |
| title_sort | diagnosis treatment and management of copd and asthma |
| topic | COPD biomass-burning HHIP sputum supernatant lung function indoor pollution chronic obstructive pulmonary disease cytokines systemic inflammation clusters adenosine triphosphate heat shock protein 70 lung cancer saliva biochemistry diagnostics prognosis 6MWT STST exercise capacity oxygen desaturation acidosis breathing cardiopulmonary exercise testing dynamic hyperinflation muscle ventilation inhaled corticosteroids (ICS) chronic obstructive pulmonary disease (COPD) blood eosinophil count (BEC) eosinophil the Global Initiative for Chronic Obstructive Lung Disease (GOLD) acute exacerbation of COPD (AECOPD) SERS multivariate analysis spirometry lower limit of normal underdiagnosis early detection app-based spirometer asthma–COPD overlap asthma fractional exhaled nitric oxide immunoglobulin E COPD guideline Asia respiratory pathophysiology bronchodilator reversibility biomarker treatment response the Brief Fatigue Inventory (BFI) the revised Short–Form McGill Pain Questionnaire 2 (SF-MPQ-2) the Kihon Checklist fatigue pain respiratory diseases inflammatory markers neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) telemedicine telehealth telemonitoring acute exacerbation COPD diagnosis prevention biomarkers biologics eosinophils inflammation neutrophils treatment n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | COPD biomass-burning HHIP sputum supernatant lung function indoor pollution chronic obstructive pulmonary disease cytokines systemic inflammation clusters adenosine triphosphate heat shock protein 70 lung cancer saliva biochemistry diagnostics prognosis 6MWT STST exercise capacity oxygen desaturation acidosis breathing cardiopulmonary exercise testing dynamic hyperinflation muscle ventilation inhaled corticosteroids (ICS) chronic obstructive pulmonary disease (COPD) blood eosinophil count (BEC) eosinophil the Global Initiative for Chronic Obstructive Lung Disease (GOLD) acute exacerbation of COPD (AECOPD) SERS multivariate analysis spirometry lower limit of normal underdiagnosis early detection app-based spirometer asthma–COPD overlap asthma fractional exhaled nitric oxide immunoglobulin E COPD guideline Asia respiratory pathophysiology bronchodilator reversibility biomarker treatment response the Brief Fatigue Inventory (BFI) the revised Short–Form McGill Pain Questionnaire 2 (SF-MPQ-2) the Kihon Checklist fatigue pain respiratory diseases inflammatory markers neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) telemedicine telehealth telemonitoring acute exacerbation COPD diagnosis prevention biomarkers biologics eosinophils inflammation neutrophils treatment n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20231130_9783036589657_165 |