Iron Metabolism, Redox Balance and Neurological Diseases
With the aging of the population, the incidence rate and number of elderly nervous system diseases have increased sharply. This event has brought huge problems to society. Despite significant efforts being made to explore new treatment options and drugs, the results have been limited. The reason may...
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| Format: | Online |
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| Jezik: | engleski |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Online pristup: | ONIX_20231130_9783036588445_279 |
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| _version_ | 1869523674321649664 |
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| collection | Directory of Open Access Books |
| description | With the aging of the population, the incidence rate and number of elderly nervous system diseases have increased sharply. This event has brought huge problems to society. Despite significant efforts being made to explore new treatment options and drugs, the results have been limited. The reason may be due to people's incomplete understanding of the pathogenesis of these age-related diseases. Iron is the most abundant trace element in the human body and is essential for normal life activities. Previous studies have shown that brain iron levels increase with age. The abnormal increase in brain iron levels is closely related to age-related neurological diseases. The disruption of the redox balance may be an important mechanism for the occurrence of neurological diseases caused by brain iron abnormalities. This Special Issue mainly highlights and discusses the latest research progress related to the regulation of brain iron metabolism, redox balance, and the pathogenesis of neurological diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), cerebral ischemia, cancer and maintenance of cellular stemness. The molecular mechanisms of iron-misregulation-induced redox imbalance in disease pathogenesis were analyzed. On this basis, further discussions were conducted on potential therapeutic targets for regulating iron metabolism to achieve effective intervention in elderly neurological diseases. |
| format | Online |
| id | doab-20.500.12854ir-128827 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1288272024-03-31T13:10:24Z Iron Metabolism, Redox Balance and Neurological Diseases Chang, Yan-Zhong glioma ferroptosis lipid peroxidation molecular mechanisms treatment CHIR99021 glycogen synthesis kinase 3 classical Wnt signaling pathway ferritin Neuro-2a cell stemness MitoQ PMMP autophagy radioprotection energy phenotype coenzyme Q10 tissue concentrations therapeutics Alzheimer’s disease dementia vascular dementia Lewy body dementia IRP2 Hif2 inhibition Fe-S clusters ferritinophagy microcytic anemia iron homeostasis iron dysregulation inflammation infection cancer iron chelation glucose metabolism NLRP3 inflammasome insulin resistance oxidative stress CY-09 OTUD3 ER stress IRE1α XBP1s Fortilin intracellular iron homeostasis neuroinflammation neurodegenerative diseases Nrf2 NF-κB 4-HNE Parkinson’s disease stroke neurodevelopment iron chelator n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries With the aging of the population, the incidence rate and number of elderly nervous system diseases have increased sharply. This event has brought huge problems to society. Despite significant efforts being made to explore new treatment options and drugs, the results have been limited. The reason may be due to people's incomplete understanding of the pathogenesis of these age-related diseases. Iron is the most abundant trace element in the human body and is essential for normal life activities. Previous studies have shown that brain iron levels increase with age. The abnormal increase in brain iron levels is closely related to age-related neurological diseases. The disruption of the redox balance may be an important mechanism for the occurrence of neurological diseases caused by brain iron abnormalities. This Special Issue mainly highlights and discusses the latest research progress related to the regulation of brain iron metabolism, redox balance, and the pathogenesis of neurological diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), cerebral ischemia, cancer and maintenance of cellular stemness. The molecular mechanisms of iron-misregulation-induced redox imbalance in disease pathogenesis were analyzed. On this basis, further discussions were conducted on potential therapeutic targets for regulating iron metabolism to achieve effective intervention in elderly neurological diseases. 2023-11-30T20:56:31Z 2023-11-30T20:56:31Z 2023 book ONIX_20231130_9783036588445_279 9783036588445 9783036588452 https://directory.doabooks.org/handle/20.500.12854/128827 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/8295 https://mdpi.com/books/pdfview/book/8295 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-8845-2 10.3390/books978-3-0365-8845-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036588445 9783036588452 210 Basel open access |
| spellingShingle | glioma ferroptosis lipid peroxidation molecular mechanisms treatment CHIR99021 glycogen synthesis kinase 3 classical Wnt signaling pathway ferritin Neuro-2a cell stemness MitoQ PMMP autophagy radioprotection energy phenotype coenzyme Q10 tissue concentrations therapeutics Alzheimer’s disease dementia vascular dementia Lewy body dementia IRP2 Hif2 inhibition Fe-S clusters ferritinophagy microcytic anemia iron homeostasis iron dysregulation inflammation infection cancer iron chelation glucose metabolism NLRP3 inflammasome insulin resistance oxidative stress CY-09 OTUD3 ER stress IRE1α XBP1s Fortilin intracellular iron homeostasis neuroinflammation neurodegenerative diseases Nrf2 NF-κB 4-HNE Parkinson’s disease stroke neurodevelopment iron chelator n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries Iron Metabolism, Redox Balance and Neurological Diseases |
| title | Iron Metabolism, Redox Balance and Neurological Diseases |
| title_full | Iron Metabolism, Redox Balance and Neurological Diseases |
| title_fullStr | Iron Metabolism, Redox Balance and Neurological Diseases |
| title_full_unstemmed | Iron Metabolism, Redox Balance and Neurological Diseases |
| title_short | Iron Metabolism, Redox Balance and Neurological Diseases |
| title_sort | iron metabolism redox balance and neurological diseases |
| topic | glioma ferroptosis lipid peroxidation molecular mechanisms treatment CHIR99021 glycogen synthesis kinase 3 classical Wnt signaling pathway ferritin Neuro-2a cell stemness MitoQ PMMP autophagy radioprotection energy phenotype coenzyme Q10 tissue concentrations therapeutics Alzheimer’s disease dementia vascular dementia Lewy body dementia IRP2 Hif2 inhibition Fe-S clusters ferritinophagy microcytic anemia iron homeostasis iron dysregulation inflammation infection cancer iron chelation glucose metabolism NLRP3 inflammasome insulin resistance oxidative stress CY-09 OTUD3 ER stress IRE1α XBP1s Fortilin intracellular iron homeostasis neuroinflammation neurodegenerative diseases Nrf2 NF-κB 4-HNE Parkinson’s disease stroke neurodevelopment iron chelator n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries |
| topic_facet | glioma ferroptosis lipid peroxidation molecular mechanisms treatment CHIR99021 glycogen synthesis kinase 3 classical Wnt signaling pathway ferritin Neuro-2a cell stemness MitoQ PMMP autophagy radioprotection energy phenotype coenzyme Q10 tissue concentrations therapeutics Alzheimer’s disease dementia vascular dementia Lewy body dementia IRP2 Hif2 inhibition Fe-S clusters ferritinophagy microcytic anemia iron homeostasis iron dysregulation inflammation infection cancer iron chelation glucose metabolism NLRP3 inflammasome insulin resistance oxidative stress CY-09 OTUD3 ER stress IRE1α XBP1s Fortilin intracellular iron homeostasis neuroinflammation neurodegenerative diseases Nrf2 NF-κB 4-HNE Parkinson’s disease stroke neurodevelopment iron chelator n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries |
| url | ONIX_20231130_9783036588445_279 |