Amyotrophic Lateral Sclerosis
Though considerable amount of research, both pre-clinical and clinical, has been conducted during recent years, Amyotrophic Lateral Sclerosis (ALS) remains one of the mysterious diseases of the 21st century. Great efforts have been made to develop pathophysiological models and to clarify the underly...
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| Format: | Online |
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| Langue: | anglais |
| Publié: |
IntechOpen
2023
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| Sujets: | |
| Accès en ligne: | ONIX_20231201_9789533078069_205 |
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| _version_ | 1869518926510030848 |
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| collection | Directory of Open Access Books |
| description | Though considerable amount of research, both pre-clinical and clinical, has been conducted during recent years, Amyotrophic Lateral Sclerosis (ALS) remains one of the mysterious diseases of the 21st century. Great efforts have been made to develop pathophysiological models and to clarify the underlying pathology, and with novel instruments in genetics and transgenic techniques, the aim for finding a durable cure comes into scope. On the other hand, most pharmacological trials failed to show a benefit for ALS patients. In this book, the reader will find a compilation of state-of-the-art reviews about the etiology, epidemiology, and pathophysiology of ALS, the molecular basis of disease progression and clinical manifestations, the genetics familial ALS, as well as novel diagnostic criteria in the field of electrophysiology. An overview over all relevant pharmacological trials in ALS patients is also included, while the book concludes with a discussion on current advances and future trends in ALS research. |
| format | Online |
| id | doab-20.500.12854ir-129098 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1290982024-03-31T22:45:07Z Amyotrophic Lateral Sclerosis Maurer, Martin H. Physiology thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Though considerable amount of research, both pre-clinical and clinical, has been conducted during recent years, Amyotrophic Lateral Sclerosis (ALS) remains one of the mysterious diseases of the 21st century. Great efforts have been made to develop pathophysiological models and to clarify the underlying pathology, and with novel instruments in genetics and transgenic techniques, the aim for finding a durable cure comes into scope. On the other hand, most pharmacological trials failed to show a benefit for ALS patients. In this book, the reader will find a compilation of state-of-the-art reviews about the etiology, epidemiology, and pathophysiology of ALS, the molecular basis of disease progression and clinical manifestations, the genetics familial ALS, as well as novel diagnostic criteria in the field of electrophysiology. An overview over all relevant pharmacological trials in ALS patients is also included, while the book concludes with a discussion on current advances and future trends in ALS research. 2023-12-01T14:50:03Z 2023-12-01T14:50:03Z 2012 book ONIX_20231201_9789533078069_205 9789533078069 9789535143796 https://directory.doabooks.org/handle/20.500.12854/129098 eng image/jpeg n/a https://www.intechopen.com/books/543 https://mts.intechopen.com/storage/books/543/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/1054 10.5772/1054 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9789533078069 9789535143796 IntechOpen 740 open access |
| spellingShingle | Physiology thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Amyotrophic Lateral Sclerosis |
| title | Amyotrophic Lateral Sclerosis |
| title_full | Amyotrophic Lateral Sclerosis |
| title_fullStr | Amyotrophic Lateral Sclerosis |
| title_full_unstemmed | Amyotrophic Lateral Sclerosis |
| title_short | Amyotrophic Lateral Sclerosis |
| title_sort | amyotrophic lateral sclerosis |
| topic | Physiology thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| topic_facet | Physiology thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| url | ONIX_20231201_9789533078069_205 |