Topics on Drug Metabolism
In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful...
Salvato in:
| Natura: | Online |
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| Lingua: | inglese |
| Pubblicazione: |
IntechOpen
2023
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| Soggetti: | |
| Accesso online: | ONIX_20231201_9789535100997_229 |
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| _version_ | 1869528026060947456 |
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| collection | Directory of Open Access Books |
| description | In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates. |
| format | Online |
| id | doab-20.500.12854ir-129122 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1291222024-04-01T14:15:03Z Topics on Drug Metabolism Paxton, James Pharmacology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates. 2023-12-01T14:52:00Z 2023-12-01T14:52:00Z 2012 book ONIX_20231201_9789535100997_229 9789535100997 9789535143543 https://directory.doabooks.org/handle/20.500.12854/129122 eng image/jpeg n/a https://www.intechopen.com/books/672 https://mts.intechopen.com/storage/books/672/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/1180 10.5772/1180 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9789535100997 9789535143543 IntechOpen 308 open access |
| spellingShingle | Pharmacology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Topics on Drug Metabolism |
| title | Topics on Drug Metabolism |
| title_full | Topics on Drug Metabolism |
| title_fullStr | Topics on Drug Metabolism |
| title_full_unstemmed | Topics on Drug Metabolism |
| title_short | Topics on Drug Metabolism |
| title_sort | topics on drug metabolism |
| topic | Pharmacology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | Pharmacology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | ONIX_20231201_9789535100997_229 |