Protein-Protein Interactions
Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last severa...
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| 格式: | Online |
|---|---|
| 語言: | 英语 |
| 出版: |
IntechOpen
2023
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| 主題: | |
| 在線閱讀: | ONIX_20231201_9789535103974_275 |
| 標簽: |
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| _version_ | 1869518746325876736 |
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| collection | Directory of Open Access Books |
| description | Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others. |
| format | Online |
| id | doab-20.500.12854ir-129167 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1291672024-04-05T17:30:43Z Protein-Protein Interactions Cai, Weibo Hong, Hao Biochemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others. 2023-12-01T14:57:47Z 2023-12-01T14:57:47Z 2012 book ONIX_20231201_9789535103974_275 9789535103974 9789535143123 https://directory.doabooks.org/handle/20.500.12854/129167 eng image/jpeg n/a https://www.intechopen.com/books/2290 https://mts.intechopen.com/storage/books/2290/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/2679 10.5772/2679 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9789535103974 9789535143123 IntechOpen 486 open access |
| spellingShingle | Biochemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry Protein-Protein Interactions |
| title | Protein-Protein Interactions |
| title_full | Protein-Protein Interactions |
| title_fullStr | Protein-Protein Interactions |
| title_full_unstemmed | Protein-Protein Interactions |
| title_short | Protein-Protein Interactions |
| title_sort | protein protein interactions |
| topic | Biochemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| topic_facet | Biochemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| url | ONIX_20231201_9789535103974_275 |