Human Skin Cancer, Potential Biomarkers and Therapeutic Targets
Skin cancers, basal and squamous cell carcinomas, malignant melanomas, and Merkel cell carcinomas, constitute arguably the most common and increasingly prevalent human neoplasms. Here we discuss the epigenetic changes in DNA and chromatin, which are increasingly associated with melanoma. Several cha...
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| 格式: | Online |
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| 語言: | 英语 |
| 出版: |
IntechOpen
2023
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| 主題: | |
| 在線閱讀: | ONIX_20231201_9789535127116_512 |
| 標簽: |
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| _version_ | 1869531571962249216 |
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| collection | Directory of Open Access Books |
| description | Skin cancers, basal and squamous cell carcinomas, malignant melanomas, and Merkel cell carcinomas, constitute arguably the most common and increasingly prevalent human neoplasms. Here we discuss the epigenetic changes in DNA and chromatin, which are increasingly associated with melanoma. Several chapters focus on the posttranscriptional modification of the proteins at the melanocyte cell surface, their role in tumorigenesis, and their potential as therapeutic targets. Specifically, extracellular modifications of integrins, glycosylation of cell surface proteins, and changes of cadherins are presented. In a very interesting approach, a potential to target the mitochondria of melanoma cells is investigated. In conclusion, this volume presents various aspects of human skin cancers, components of the large worldwide effort to combat and eradicate this growing health concern. |
| format | Online |
| id | doab-20.500.12854ir-129403 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1294032024-03-31T22:43:42Z Human Skin Cancer, Potential Biomarkers and Therapeutic Targets Blumenberg, Miroslav melanoma, glycosylation, epigenetics, metastasis, cytotoxicity, migration thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology Skin cancers, basal and squamous cell carcinomas, malignant melanomas, and Merkel cell carcinomas, constitute arguably the most common and increasingly prevalent human neoplasms. Here we discuss the epigenetic changes in DNA and chromatin, which are increasingly associated with melanoma. Several chapters focus on the posttranscriptional modification of the proteins at the melanocyte cell surface, their role in tumorigenesis, and their potential as therapeutic targets. Specifically, extracellular modifications of integrins, glycosylation of cell surface proteins, and changes of cadherins are presented. In a very interesting approach, a potential to target the mitochondria of melanoma cells is investigated. In conclusion, this volume presents various aspects of human skin cancers, components of the large worldwide effort to combat and eradicate this growing health concern. 2023-12-01T15:21:57Z 2023-12-01T15:21:57Z 2016 book ONIX_20231201_9789535127116_512 9789535127116 9789535127109 9789535173175 https://directory.doabooks.org/handle/20.500.12854/129403 eng image/jpeg n/a https://www.intechopen.com/books/5303 https://mts.intechopen.com/storage/books/5303/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/61922 10.5772/61922 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9789535127116 9789535127109 9789535173175 IntechOpen 150 open access |
| spellingShingle | melanoma, glycosylation, epigenetics, metastasis, cytotoxicity, migration thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology Human Skin Cancer, Potential Biomarkers and Therapeutic Targets |
| title | Human Skin Cancer, Potential Biomarkers and Therapeutic Targets |
| title_full | Human Skin Cancer, Potential Biomarkers and Therapeutic Targets |
| title_fullStr | Human Skin Cancer, Potential Biomarkers and Therapeutic Targets |
| title_full_unstemmed | Human Skin Cancer, Potential Biomarkers and Therapeutic Targets |
| title_short | Human Skin Cancer, Potential Biomarkers and Therapeutic Targets |
| title_sort | human skin cancer potential biomarkers and therapeutic targets |
| topic | melanoma, glycosylation, epigenetics, metastasis, cytotoxicity, migration thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| topic_facet | melanoma, glycosylation, epigenetics, metastasis, cytotoxicity, migration thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| url | ONIX_20231201_9789535127116_512 |