Prion
Protein aggregation causes malfunction in several biochemical processes. Genetic and spontaneous formations of these transmissible spongiform encephalopathies are fatal to humans and animals. Conformational change of normal form of the protein to misfolded form causes its accumulation. The misfolded...
সংরক্ষণ করুন:
| বিন্যাস: | Online |
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| ভাষা: | ইংরেজি |
| প্রকাশিত: |
IntechOpen
2023
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | ONIX_20231201_9789535130024_564 |
| ট্যাগগুলো: |
কোনো ট্যাগ নেই, প্রথমজন হিসাবে ট্যাগ করুন!
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| _version_ | 1869516300282232832 |
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| collection | Directory of Open Access Books |
| description | Protein aggregation causes malfunction in several biochemical processes. Genetic and spontaneous formations of these transmissible spongiform encephalopathies are fatal to humans and animals. Conformational change of normal form of the protein to misfolded form causes its accumulation. The misfolded infectious protein agent forms the pathogenesis of the disease. This book presents pathology of the disease along with current knowledge of the structure-activity mechanism in the first two sections. Dyshomeostasis of metals is implicated in the pathogenesis of prions, and this influence is discussed further to understand the prion mechanism. Genetic resistance and immunobiology of the disease are elaborated in the following section. Finally, a computational study on the dynamics of the prion propagation provides a structural basis of the mechanism. |
| format | Online |
| id | doab-20.500.12854ir-129455 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1294552024-03-31T22:45:37Z Prion Tutar, Yusuf Infectious & contagious diseases thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases Protein aggregation causes malfunction in several biochemical processes. Genetic and spontaneous formations of these transmissible spongiform encephalopathies are fatal to humans and animals. Conformational change of normal form of the protein to misfolded form causes its accumulation. The misfolded infectious protein agent forms the pathogenesis of the disease. This book presents pathology of the disease along with current knowledge of the structure-activity mechanism in the first two sections. Dyshomeostasis of metals is implicated in the pathogenesis of prions, and this influence is discussed further to understand the prion mechanism. Genetic resistance and immunobiology of the disease are elaborated in the following section. Finally, a computational study on the dynamics of the prion propagation provides a structural basis of the mechanism. 2023-12-01T15:27:28Z 2023-12-01T15:27:28Z 2017 book ONIX_20231201_9789535130024_564 9789535130024 9789535130017 9789535173496 https://directory.doabooks.org/handle/20.500.12854/129455 eng image/jpeg n/a https://www.intechopen.com/books/5531 https://mts.intechopen.com/storage/books/5531/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/63289 10.5772/63289 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9789535130024 9789535130017 9789535173496 IntechOpen 238 open access |
| spellingShingle | Infectious & contagious diseases thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases Prion |
| title | Prion |
| title_full | Prion |
| title_fullStr | Prion |
| title_full_unstemmed | Prion |
| title_short | Prion |
| title_sort | prion |
| topic | Infectious & contagious diseases thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases |
| topic_facet | Infectious & contagious diseases thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases |
| url | ONIX_20231201_9789535130024_564 |