Peripheral Nerve Regeneration
Peripheral nerve injuries are a high-incidence clinical problem that greatly affects patients' quality of life. Despite continuous refinement of microsurgery techniques, peripheral nerve repair still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is...
שמור ב:
| פורמט: | Online |
|---|---|
| שפה: | אנגלית |
| יצא לאור: |
IntechOpen
2023
|
| נושאים: | |
| גישה מקוונת: | ONIX_20231201_9789535131663_599 |
| תגים: |
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!
|
| _version_ | 1869523731482673152 |
|---|---|
| collection | Directory of Open Access Books |
| description | Peripheral nerve injuries are a high-incidence clinical problem that greatly affects patients' quality of life. Despite continuous refinement of microsurgery techniques, peripheral nerve repair still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory in these patients. Therefore, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. Direct nerve repair with epineural end-to-end sutures is still the gold standard treatment for severe neurotmesis injuries but only in cases where well-vascularized tension-free coaptation can be achieved. When peripheral nerve injury originates a significant gap between the nerve stumps, nerve grafts are required, with several associated disadvantages. Therefore, the development of scaffolds by tissue engineering can provide efficient treatment alternatives to stimulate optimum clinical outcome. Nerve conduit tailoring involves reaching ideal wall pores, using electrospinning techniques in their fabrication, surface coating with extracellular matrix materials, and adding of growth factors or cell-based therapies, among other possibilities. Also, intraluminal cues are employed such as the filling with hydrogels, inner surface modification, topographical design, and the introduction of neurotrophic factors, antibiotics, anti-inflammatories and other pharmacological agents. A comprehensive state of the art of surgical techniques, tissue-engineered nerve graft scaffolds, and their application in nerve regeneration, the advances in peripheral nerve repair and future perspectives will be discussed, including surgeons' and researchers' own large experience in this field of knowledge. |
| format | Online |
| id | doab-20.500.12854ir-129490 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1294902024-04-05T17:30:00Z Peripheral Nerve Regeneration Colette Mauricio, Ana apoptosis, migration, injury, proliferation, carpal tunnel syndrome, adult neurogenesis thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Peripheral nerve injuries are a high-incidence clinical problem that greatly affects patients' quality of life. Despite continuous refinement of microsurgery techniques, peripheral nerve repair still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory in these patients. Therefore, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. Direct nerve repair with epineural end-to-end sutures is still the gold standard treatment for severe neurotmesis injuries but only in cases where well-vascularized tension-free coaptation can be achieved. When peripheral nerve injury originates a significant gap between the nerve stumps, nerve grafts are required, with several associated disadvantages. Therefore, the development of scaffolds by tissue engineering can provide efficient treatment alternatives to stimulate optimum clinical outcome. Nerve conduit tailoring involves reaching ideal wall pores, using electrospinning techniques in their fabrication, surface coating with extracellular matrix materials, and adding of growth factors or cell-based therapies, among other possibilities. Also, intraluminal cues are employed such as the filling with hydrogels, inner surface modification, topographical design, and the introduction of neurotrophic factors, antibiotics, anti-inflammatories and other pharmacological agents. A comprehensive state of the art of surgical techniques, tissue-engineered nerve graft scaffolds, and their application in nerve regeneration, the advances in peripheral nerve repair and future perspectives will be discussed, including surgeons' and researchers' own large experience in this field of knowledge. 2023-12-01T15:31:16Z 2023-12-01T15:31:16Z 2017 book ONIX_20231201_9789535131663_599 9789535131663 9789535131656 9789535148128 https://directory.doabooks.org/handle/20.500.12854/129490 eng image/jpeg n/a https://www.intechopen.com/books/5852 https://mts.intechopen.com/storage/books/5852/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/65612 10.5772/65612 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9789535131663 9789535131656 9789535148128 IntechOpen 224 open access |
| spellingShingle | apoptosis, migration, injury, proliferation, carpal tunnel syndrome, adult neurogenesis thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Peripheral Nerve Regeneration |
| title | Peripheral Nerve Regeneration |
| title_full | Peripheral Nerve Regeneration |
| title_fullStr | Peripheral Nerve Regeneration |
| title_full_unstemmed | Peripheral Nerve Regeneration |
| title_short | Peripheral Nerve Regeneration |
| title_sort | peripheral nerve regeneration |
| topic | apoptosis, migration, injury, proliferation, carpal tunnel syndrome, adult neurogenesis thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | apoptosis, migration, injury, proliferation, carpal tunnel syndrome, adult neurogenesis thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | ONIX_20231201_9789535131663_599 |