Protein Phosphorylation
Protein phosphorylation reactions are carried out in a cell by protein kinases, which predominantly use ATP as a phosphate donor that is transferred and covalently bound to an amino acid on a substrate protein. Protein phosphorylation was discovered in 1954 by Edmond Fischer who shared the Nobel Pri...
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| フォーマット: | Online |
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| 言語: | 英語 |
| 出版事項: |
IntechOpen
2023
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| 主題: | |
| オンライン･アクセス: | ONIX_20231201_9789535136262_634 |
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| _version_ | 1869521601809088512 |
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| collection | Directory of Open Access Books |
| description | Protein phosphorylation reactions are carried out in a cell by protein kinases, which predominantly use ATP as a phosphate donor that is transferred and covalently bound to an amino acid on a substrate protein. Protein phosphorylation was discovered in 1954 by Edmond Fischer who shared the Nobel Prize in Medicine or Physiology in 1992 with Edwin Krebs. There are so many kinases that one was called "Just Another Kinase" for JAK kinase. Their counterpart is protein phosphatases that remove phosphates from phosphorylated proteins. Kinases and phosphatases act as switches in the cell that activates or inactivates protein functions. These reactions are reversible; the cell can quickly react to a situation but can then go back to its initial state. |
| format | Online |
| id | doab-20.500.12854ir-129525 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1295252024-04-05T17:30:45Z Protein Phosphorylation Prigent, Claude cancer, biomarker, biosensor, aggregation, spinal cord injury, neurotoxicity thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry Protein phosphorylation reactions are carried out in a cell by protein kinases, which predominantly use ATP as a phosphate donor that is transferred and covalently bound to an amino acid on a substrate protein. Protein phosphorylation was discovered in 1954 by Edmond Fischer who shared the Nobel Prize in Medicine or Physiology in 1992 with Edwin Krebs. There are so many kinases that one was called "Just Another Kinase" for JAK kinase. Their counterpart is protein phosphatases that remove phosphates from phosphorylated proteins. Kinases and phosphatases act as switches in the cell that activates or inactivates protein functions. These reactions are reversible; the cell can quickly react to a situation but can then go back to its initial state. 2023-12-01T15:35:13Z 2023-12-01T15:35:13Z 2017 book ONIX_20231201_9789535136262_634 9789535136262 9789535136255 9789535145967 https://directory.doabooks.org/handle/20.500.12854/129525 eng image/jpeg n/a https://www.intechopen.com/books/5855 https://mts.intechopen.com/storage/books/5855/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/65615 10.5772/65615 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9789535136262 9789535136255 9789535145967 IntechOpen 204 open access |
| spellingShingle | cancer, biomarker, biosensor, aggregation, spinal cord injury, neurotoxicity thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry Protein Phosphorylation |
| title | Protein Phosphorylation |
| title_full | Protein Phosphorylation |
| title_fullStr | Protein Phosphorylation |
| title_full_unstemmed | Protein Phosphorylation |
| title_short | Protein Phosphorylation |
| title_sort | protein phosphorylation |
| topic | cancer, biomarker, biosensor, aggregation, spinal cord injury, neurotoxicity thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| topic_facet | cancer, biomarker, biosensor, aggregation, spinal cord injury, neurotoxicity thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| url | ONIX_20231201_9789535136262_634 |