New Developments in the Pathogenesis of Rheumatoid Arthritis
The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. HLA class II alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (ACPAs), along with the effectiveness of biological treatments targeting cytokines, such as TNF-?, IL-...
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| Format: | Online |
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| Language: | English |
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IntechOpen
2023
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| Online Access: | ONIX_20231201_9789535129707_689 |
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| description | The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. HLA class II alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (ACPAs), along with the effectiveness of biological treatments targeting cytokines, such as TNF-?, IL-6, and also T cells and B cells, reinforced the pathogenetic role of the respective factors. ACPAs, induced by cigarette smoking and periodontitis in individuals with HLA-DRB1 shared epitope, appear to be autoantigens that initiate the inflammatory immune response in RA. MicroRNAs, part of epigenetic mechanisms, which also include DNA methylation, and histone modification, as well as microbiota, the composition of microbes in body cavities, also appear to influence arthritis and are discussed in this book. |
| format | Online |
| id | doab-20.500.12854ir-129580 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
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| spelling | doab-20.500.12854ir-1295802024-03-31T22:43:48Z New Developments in the Pathogenesis of Rheumatoid Arthritis Sakkas, Lazaros I. cytokines, microrna, biomarkers, epigenetics, microbiota, mirna thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. HLA class II alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (ACPAs), along with the effectiveness of biological treatments targeting cytokines, such as TNF-?, IL-6, and also T cells and B cells, reinforced the pathogenetic role of the respective factors. ACPAs, induced by cigarette smoking and periodontitis in individuals with HLA-DRB1 shared epitope, appear to be autoantigens that initiate the inflammatory immune response in RA. MicroRNAs, part of epigenetic mechanisms, which also include DNA methylation, and histone modification, as well as microbiota, the composition of microbes in body cavities, also appear to influence arthritis and are discussed in this book. 2023-12-01T15:41:09Z 2023-12-01T15:41:09Z 2017 book ONIX_20231201_9789535129707_689 9789535129707 9789535129691 9789535173427 https://directory.doabooks.org/handle/20.500.12854/129580 eng image/jpeg n/a https://www.intechopen.com/books/5501 https://mts.intechopen.com/storage/books/5501/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/63175 10.5772/63175 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9789535129707 9789535129691 9789535173427 IntechOpen 164 open access |
| spellingShingle | cytokines, microrna, biomarkers, epigenetics, microbiota, mirna thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology New Developments in the Pathogenesis of Rheumatoid Arthritis |
| title | New Developments in the Pathogenesis of Rheumatoid Arthritis |
| title_full | New Developments in the Pathogenesis of Rheumatoid Arthritis |
| title_fullStr | New Developments in the Pathogenesis of Rheumatoid Arthritis |
| title_full_unstemmed | New Developments in the Pathogenesis of Rheumatoid Arthritis |
| title_short | New Developments in the Pathogenesis of Rheumatoid Arthritis |
| title_sort | new developments in the pathogenesis of rheumatoid arthritis |
| topic | cytokines, microrna, biomarkers, epigenetics, microbiota, mirna thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology |
| topic_facet | cytokines, microrna, biomarkers, epigenetics, microbiota, mirna thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology |
| url | ONIX_20231201_9789535129707_689 |