Huntington's Disease
Huntington's disease is a progressive neurodegenerative disorder of the brain. It is one of the quite devastating and currently incurable human conditions. Degeneration of specific types of neurons in the brain results in a triad of clinical features: serious behavioral disturbances, uncontrolled mo...
שמור ב:
| פורמט: | Online |
|---|---|
| שפה: | אנגלית |
| יצא לאור: |
IntechOpen
2023
|
| נושאים: | |
| גישה מקוונת: | ONIX_20231201_9789535130505_785 |
| תגים: |
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!
|
| _version_ | 1869522738598641664 |
|---|---|
| collection | Directory of Open Access Books |
| description | Huntington's disease is a progressive neurodegenerative disorder of the brain. It is one of the quite devastating and currently incurable human conditions. Degeneration of specific types of neurons in the brain results in a triad of clinical features: serious behavioral disturbances, uncontrolled movements of body parts, and deterioration of intellectual capabilities. The underlying complex mechanisms and molecular players of the cellular cascades still need to be deciphered in detail despite considerable advances. Once solved, the related molecular mechanisms will not only enlighten the HD story but will also shed light on other polyglutamine diseases and similar brain disorders. This book, Huntington's Disease-Molecular Pathogenesis and Current Models, is planned to cover recent scientific achievements in understanding the cellular mechanisms of HD. The chapters provide comprehensive description of the key issues in HD research. In this regard, this book will serve as a source for clinicians and researchers in the field and also for life science readers in increasing their understanding and awareness of the clinical correlates, genetic aspects, neuropathological findings, and potential therapeutic interventions related to HD. |
| format | Online |
| id | doab-20.500.12854ir-129676 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1296762024-04-01T14:15:16Z Huntington's Disease Ersoy Tunalı, Nagehan huntington’s disease, pluripotent stem cells, glutamate, creb, mouse models, mmr thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology Huntington's disease is a progressive neurodegenerative disorder of the brain. It is one of the quite devastating and currently incurable human conditions. Degeneration of specific types of neurons in the brain results in a triad of clinical features: serious behavioral disturbances, uncontrolled movements of body parts, and deterioration of intellectual capabilities. The underlying complex mechanisms and molecular players of the cellular cascades still need to be deciphered in detail despite considerable advances. Once solved, the related molecular mechanisms will not only enlighten the HD story but will also shed light on other polyglutamine diseases and similar brain disorders. This book, Huntington's Disease-Molecular Pathogenesis and Current Models, is planned to cover recent scientific achievements in understanding the cellular mechanisms of HD. The chapters provide comprehensive description of the key issues in HD research. In this regard, this book will serve as a source for clinicians and researchers in the field and also for life science readers in increasing their understanding and awareness of the clinical correlates, genetic aspects, neuropathological findings, and potential therapeutic interventions related to HD. 2023-12-01T15:56:36Z 2023-12-01T15:56:36Z 2017 book ONIX_20231201_9789535130505_785 9789535130505 9789535130499 9789535148975 https://directory.doabooks.org/handle/20.500.12854/129676 eng image/jpeg n/a https://www.intechopen.com/books/5460 https://mts.intechopen.com/storage/books/5460/authors_book/authors_book.pdf IntechOpen The Huntington IntechOpen 10.5772/62999 10.5772/62999 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 1c332c1a-850f-45a4-b7c7-56409bcf68bc 9789535130505 9789535130499 9789535148975 IntechOpen 152 open access |
| spellingShingle | huntington’s disease, pluripotent stem cells, glutamate, creb, mouse models, mmr thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology Huntington's Disease |
| title | Huntington's Disease |
| title_full | Huntington's Disease |
| title_fullStr | Huntington's Disease |
| title_full_unstemmed | Huntington's Disease |
| title_short | Huntington's Disease |
| title_sort | huntington s disease |
| topic | huntington’s disease, pluripotent stem cells, glutamate, creb, mouse models, mmr thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology |
| topic_facet | huntington’s disease, pluripotent stem cells, glutamate, creb, mouse models, mmr thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology |
| url | ONIX_20231201_9789535130505_785 |