Renin-Angiotensin System
Exploring the contractile activity of smooth muscle segments isolated from various organs of healthy animals and animals with experimentally induced diabetes, she obtained original data about angiotensin II-induced force and time parameters. For the first time, she established the effect of ghrelin...
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| Format: | Online |
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| Jezik: | engleski |
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IntechOpen
2023
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| Online pristup: | ONIX_20231201_9789535133520_788 |
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| collection | Directory of Open Access Books |
| description | Exploring the contractile activity of smooth muscle segments isolated from various organs of healthy animals and animals with experimentally induced diabetes, she obtained original data about angiotensin II-induced force and time parameters. For the first time, she established the effect of ghrelin on angiotensin II-provoked contraction of the urinary bladder. Original data on the role of both types of angiotensin receptors for the contractile activity of the various segments of the gastrointestinal tract and bladder were obtained. By applying specific software for force and time parameter analysis, the contribution of different types of angiotensin receptors on muscle contractility has been shown. The new methodology was used to analyze the data obtained during the registration of smooth muscle relaxation activity, which allows the determination of not only the magnitude of the mechanical response but also the parameters related to the time and speed of the contractions. Plasma renin activity models have been developed using mathematical approaches to predict the effect of different drug doses on the behavior of the system. |
| format | Online |
| id | doab-20.500.12854ir-129679 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1296792024-03-31T22:44:15Z Renin-Angiotensin System Naidenova Tolekova, Anna hypertension, biomarkers, heart failure, atherosclerosis, reactive oxygen species, chronic kidney disease thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJG Endocrinology Exploring the contractile activity of smooth muscle segments isolated from various organs of healthy animals and animals with experimentally induced diabetes, she obtained original data about angiotensin II-induced force and time parameters. For the first time, she established the effect of ghrelin on angiotensin II-provoked contraction of the urinary bladder. Original data on the role of both types of angiotensin receptors for the contractile activity of the various segments of the gastrointestinal tract and bladder were obtained. By applying specific software for force and time parameter analysis, the contribution of different types of angiotensin receptors on muscle contractility has been shown. The new methodology was used to analyze the data obtained during the registration of smooth muscle relaxation activity, which allows the determination of not only the magnitude of the mechanical response but also the parameters related to the time and speed of the contractions. Plasma renin activity models have been developed using mathematical approaches to predict the effect of different drug doses on the behavior of the system. 2023-12-01T15:57:14Z 2023-12-01T15:57:14Z 2017 book ONIX_20231201_9789535133520_788 9789535133520 9789535133513 9789535147480 https://directory.doabooks.org/handle/20.500.12854/129679 eng image/jpeg n/a https://www.intechopen.com/books/5504 https://mts.intechopen.com/storage/books/5504/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/63179 10.5772/63179 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9789535133520 9789535133513 9789535147480 IntechOpen 268 open access |
| spellingShingle | hypertension, biomarkers, heart failure, atherosclerosis, reactive oxygen species, chronic kidney disease thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJG Endocrinology Renin-Angiotensin System |
| title | Renin-Angiotensin System |
| title_full | Renin-Angiotensin System |
| title_fullStr | Renin-Angiotensin System |
| title_full_unstemmed | Renin-Angiotensin System |
| title_short | Renin-Angiotensin System |
| title_sort | renin angiotensin system |
| topic | hypertension, biomarkers, heart failure, atherosclerosis, reactive oxygen species, chronic kidney disease thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJG Endocrinology |
| topic_facet | hypertension, biomarkers, heart failure, atherosclerosis, reactive oxygen species, chronic kidney disease thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJG Endocrinology |
| url | ONIX_20231201_9789535133520_788 |