New Insights into Systemic Sclerosis
Systemic sclerosis (scleroderma) is an incurable connective tissue disease of unknown etiology. Three key processes play a pivotal role in the pathogenesis: immune dysregulation and inflammation, endothelial injury and vasculopathy, and fibrosis. Tissue fibrosis is the dominant and characteristic fe...
Guardado en:
| Formato: | Online |
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| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2023
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| Materias: | |
| Acceso en línea: | ONIX_20231201_9781839622052_1785 |
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| _version_ | 1869523128252628992 |
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| collection | Directory of Open Access Books |
| description | Systemic sclerosis (scleroderma) is an incurable connective tissue disease of unknown etiology. Three key processes play a pivotal role in the pathogenesis: immune dysregulation and inflammation, endothelial injury and vasculopathy, and fibrosis. Tissue fibrosis is the dominant and characteristic feature that affects the skin and visceral organs. Life expectancy of scleroderma patients has improved over recent years, mainly because of better treatment of organ involvement and complications; however, no curative disease-modifying therapies exist to date. This book aims to provide students, trainees, rheumatologists, and other specialists interested in this disease with a comprehensive overview of novel pathogenetic mechanisms, management approaches, and therapeutic targets of several major vascular and fibrotic manifestations, and is useful insight into a number of usually neglected aspects of scleroderma. |
| format | Online |
| id | doab-20.500.12854ir-130676 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1306762024-03-31T22:43:51Z New Insights into Systemic Sclerosis Tomcik, Michal erectile dysfunction, stress, malnutrition, nitric oxide, kidney, body composition thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology Systemic sclerosis (scleroderma) is an incurable connective tissue disease of unknown etiology. Three key processes play a pivotal role in the pathogenesis: immune dysregulation and inflammation, endothelial injury and vasculopathy, and fibrosis. Tissue fibrosis is the dominant and characteristic feature that affects the skin and visceral organs. Life expectancy of scleroderma patients has improved over recent years, mainly because of better treatment of organ involvement and complications; however, no curative disease-modifying therapies exist to date. This book aims to provide students, trainees, rheumatologists, and other specialists interested in this disease with a comprehensive overview of novel pathogenetic mechanisms, management approaches, and therapeutic targets of several major vascular and fibrotic manifestations, and is useful insight into a number of usually neglected aspects of scleroderma. 2023-12-01T18:05:53Z 2023-12-01T18:05:53Z 2019 book ONIX_20231201_9781839622052_1785 9781839622052 9781839622045 9781839622069 https://directory.doabooks.org/handle/20.500.12854/130676 eng image/jpeg n/a https://www.intechopen.com/books/8269 https://mts.intechopen.com/storage/books/8269/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/intechopen.78254 10.5772/intechopen.78254 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9781839622052 9781839622045 9781839622069 IntechOpen 160 open access |
| spellingShingle | erectile dysfunction, stress, malnutrition, nitric oxide, kidney, body composition thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology New Insights into Systemic Sclerosis |
| title | New Insights into Systemic Sclerosis |
| title_full | New Insights into Systemic Sclerosis |
| title_fullStr | New Insights into Systemic Sclerosis |
| title_full_unstemmed | New Insights into Systemic Sclerosis |
| title_short | New Insights into Systemic Sclerosis |
| title_sort | new insights into systemic sclerosis |
| topic | erectile dysfunction, stress, malnutrition, nitric oxide, kidney, body composition thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology |
| topic_facet | erectile dysfunction, stress, malnutrition, nitric oxide, kidney, body composition thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology |
| url | ONIX_20231201_9781839622052_1785 |