Drug Metabolism
Drug metabolism comprises the identification, characterization, and quantification of the chemicals or compounds produced in an animal or human upon administration of a drug. Research practices not only require the chemical structure but also aim to determine the pharmacological activities and/or to...
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| Формат: | Online |
|---|---|
| Язык: | английский |
| Опубликовано: |
IntechOpen
2023
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| Предметы: | |
| Online-ссылка: | ONIX_20231201_9781839688805_2115 |
| Метки: |
Нет меток, Требуется 1-ая метка записи!
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| _version_ | 1869525323225235456 |
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| collection | Directory of Open Access Books |
| description | Drug metabolism comprises the identification, characterization, and quantification of the chemicals or compounds produced in an animal or human upon administration of a drug. Research practices not only require the chemical structure but also aim to determine the pharmacological activities and/or toxicity of these compounds. This is first performed in animals, as studies attempt to identify and quantify metabolites, and later in humans, with care to further characterize metabolites that are either unique to or produced disproportionately in humans compared to animals. Characterization includes the determination of enzyme systems or other biological mechanisms that produce each identified metabolite; this information is used to predict potential drug-drug interactions with other compounds that increase or decrease metabolite formation and sources of biological variability in response or toxicity with varying patient genetics, which affect CYP isoform expression. This book’s purpose is to provide some understanding of the biology and current technology applied in the field of drug metabolism. |
| format | Online |
| id | doab-20.500.12854ir-131004 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1310042024-04-01T14:15:00Z Drug Metabolism Dunnington, Katherine diabetes, drug discovery, phytochemicals, natural products, pharmacogenetics, biotransformation thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Drug metabolism comprises the identification, characterization, and quantification of the chemicals or compounds produced in an animal or human upon administration of a drug. Research practices not only require the chemical structure but also aim to determine the pharmacological activities and/or toxicity of these compounds. This is first performed in animals, as studies attempt to identify and quantify metabolites, and later in humans, with care to further characterize metabolites that are either unique to or produced disproportionately in humans compared to animals. Characterization includes the determination of enzyme systems or other biological mechanisms that produce each identified metabolite; this information is used to predict potential drug-drug interactions with other compounds that increase or decrease metabolite formation and sources of biological variability in response or toxicity with varying patient genetics, which affect CYP isoform expression. This book’s purpose is to provide some understanding of the biology and current technology applied in the field of drug metabolism. 2023-12-01T18:39:25Z 2023-12-01T18:39:25Z 2021 book ONIX_20231201_9781839688805_2115 9781839688805 9781839688799 9781839688812 https://directory.doabooks.org/handle/20.500.12854/131004 eng image/jpeg n/a https://www.intechopen.com/books/10357 https://mts.intechopen.com/storage/books/10357/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/intechopen.91543 10.5772/intechopen.91543 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9781839688805 9781839688799 9781839688812 IntechOpen 108 open access |
| spellingShingle | diabetes, drug discovery, phytochemicals, natural products, pharmacogenetics, biotransformation thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Drug Metabolism |
| title | Drug Metabolism |
| title_full | Drug Metabolism |
| title_fullStr | Drug Metabolism |
| title_full_unstemmed | Drug Metabolism |
| title_short | Drug Metabolism |
| title_sort | drug metabolism |
| topic | diabetes, drug discovery, phytochemicals, natural products, pharmacogenetics, biotransformation thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | diabetes, drug discovery, phytochemicals, natural products, pharmacogenetics, biotransformation thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | ONIX_20231201_9781839688805_2115 |