Melanoma
Although melanoma represents a limited number of cutaneous cancers each year, it remains a significant public health crisis because the metastatic disease is associated with poor survival. The incidence of the disease has increased 200% since 1973 and the median age at diagnosis is 40 years, making...
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| Materyal Türü: | Online |
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| Dil: | İngilizce |
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IntechOpen
2023
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| Konular: | |
| Online Erişim: | ONIX_20231201_9781838808792_2314 |
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| _version_ | 1869523845715591168 |
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| collection | Directory of Open Access Books |
| description | Although melanoma represents a limited number of cutaneous cancers each year, it remains a significant public health crisis because the metastatic disease is associated with poor survival. The incidence of the disease has increased 200% since 1973 and the median age at diagnosis is 40 years, making it one of the most significant cancers responsible for productive years of life lost. Fortunately, there has been unprecedented progress in the treatment of advanced melanoma, largely through advances in understanding how to manipulate immune responses and target selective genetic mutations in melanoma patients. Clinical benefits to patients with advanced melanoma have been nevertheless limited by the development of innate and acquired drug resistance, and numerous efforts are focusing on the elucidation of these mechanisms. Combination strategies are being actively investigated to overcome drug resistance, by awakening existing anti-tumor mechanisms disabled by a cancer-promoting microenvironment. This book explores the advances and challenges associated with melanoma today, particularly those related to its diagnosis and management. It also proposes new avenues for therapeutic opportunities based on sustained research efforts and ever-growing technological advances. This is a relevant source of knowledge, very useful for researchers, medical doctors, health providers and all individuals interested in learning more about this devastating disease. |
| format | Online |
| id | doab-20.500.12854ir-131203 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1312032024-03-31T22:43:33Z Melanoma Lasfar, Ahmed Cohen-Solal, Karine radiotherapy, braf, stereotactic radiosurgery, egfr, malignant melanoma, rectum thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology Although melanoma represents a limited number of cutaneous cancers each year, it remains a significant public health crisis because the metastatic disease is associated with poor survival. The incidence of the disease has increased 200% since 1973 and the median age at diagnosis is 40 years, making it one of the most significant cancers responsible for productive years of life lost. Fortunately, there has been unprecedented progress in the treatment of advanced melanoma, largely through advances in understanding how to manipulate immune responses and target selective genetic mutations in melanoma patients. Clinical benefits to patients with advanced melanoma have been nevertheless limited by the development of innate and acquired drug resistance, and numerous efforts are focusing on the elucidation of these mechanisms. Combination strategies are being actively investigated to overcome drug resistance, by awakening existing anti-tumor mechanisms disabled by a cancer-promoting microenvironment. This book explores the advances and challenges associated with melanoma today, particularly those related to its diagnosis and management. It also proposes new avenues for therapeutic opportunities based on sustained research efforts and ever-growing technological advances. This is a relevant source of knowledge, very useful for researchers, medical doctors, health providers and all individuals interested in learning more about this devastating disease. 2023-12-01T19:01:37Z 2023-12-01T19:01:37Z 2021 book ONIX_20231201_9781838808792_2314 9781838808792 9781838808785 9781838808808 https://directory.doabooks.org/handle/20.500.12854/131203 eng image/jpeg n/a https://www.intechopen.com/books/10338 https://mts.intechopen.com/storage/books/10338/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/intechopen.91524 10.5772/intechopen.91524 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9781838808792 9781838808785 9781838808808 IntechOpen 148 open access |
| spellingShingle | radiotherapy, braf, stereotactic radiosurgery, egfr, malignant melanoma, rectum thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology Melanoma |
| title | Melanoma |
| title_full | Melanoma |
| title_fullStr | Melanoma |
| title_full_unstemmed | Melanoma |
| title_short | Melanoma |
| title_sort | melanoma |
| topic | radiotherapy, braf, stereotactic radiosurgery, egfr, malignant melanoma, rectum thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| topic_facet | radiotherapy, braf, stereotactic radiosurgery, egfr, malignant melanoma, rectum thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| url | ONIX_20231201_9781838808792_2314 |