Hsp90 Structure, Mechanism and Disease
The Hsp90 chaperone complex is responsible for the activation and maturation of a vast array of signaling proteins. Recently, there has been a leap in our understanding of the Hsp90 structure and molecular mechanisms involved in such regulation. This has opened a doorway to the underlying mechanisms...
Furkejuvvon:
| Materiálatiipa: | Online |
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| Giella: | eaŋgalasgiella |
| Almmustuhtton: |
MDPI - Multidisciplinary Digital Publishing Institute
2024
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| Fáttát: | |
| Liŋkkat: | ONIX_20240108_9783036597140_41 |
| Fáddágilkorat: |
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| _version_ | 1869517179017232384 |
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| collection | Directory of Open Access Books |
| description | The Hsp90 chaperone complex is responsible for the activation and maturation of a vast array of signaling proteins. Recently, there has been a leap in our understanding of the Hsp90 structure and molecular mechanisms involved in such regulation. This has opened a doorway to the underlying mechanisms of disease processes and how we may intervene in such mechanisms to improve prognosis. The focus of this Special Issue is on the recent structural and biochemical advances of Hsp90 that provide insights into the mechanistic activation of Hsp90 on client proteins. It will also include discussions on Hsp90 and its co-chaperones, and their potential as therapeutic targets against human diseases. |
| format | Online |
| id | doab-20.500.12854ir-132382 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1323822024-03-28T03:31:10Z Hsp90 Structure, Mechanism and Disease Prodromou, Chrisostomos Hsp90 heat shock proteins chaperone structure mechanism regulation disease cancer neurological disease drug development thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry The Hsp90 chaperone complex is responsible for the activation and maturation of a vast array of signaling proteins. Recently, there has been a leap in our understanding of the Hsp90 structure and molecular mechanisms involved in such regulation. This has opened a doorway to the underlying mechanisms of disease processes and how we may intervene in such mechanisms to improve prognosis. The focus of this Special Issue is on the recent structural and biochemical advances of Hsp90 that provide insights into the mechanistic activation of Hsp90 on client proteins. It will also include discussions on Hsp90 and its co-chaperones, and their potential as therapeutic targets against human diseases. 2024-01-08T14:44:27Z 2024-01-08T14:44:27Z 2023 book ONIX_20240108_9783036597140_41 9783036597140 9783036597157 https://directory.doabooks.org/handle/20.500.12854/132382 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/8399 https://mdpi.com/books/pdfview/book/8399 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-9715-7 10.3390/books978-3-0365-9715-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036597140 9783036597157 304 Basel open access |
| spellingShingle | Hsp90 heat shock proteins chaperone structure mechanism regulation disease cancer neurological disease drug development thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry Hsp90 Structure, Mechanism and Disease |
| title | Hsp90 Structure, Mechanism and Disease |
| title_full | Hsp90 Structure, Mechanism and Disease |
| title_fullStr | Hsp90 Structure, Mechanism and Disease |
| title_full_unstemmed | Hsp90 Structure, Mechanism and Disease |
| title_short | Hsp90 Structure, Mechanism and Disease |
| title_sort | hsp90 structure mechanism and disease |
| topic | Hsp90 heat shock proteins chaperone structure mechanism regulation disease cancer neurological disease drug development thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| topic_facet | Hsp90 heat shock proteins chaperone structure mechanism regulation disease cancer neurological disease drug development thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| url | ONIX_20240108_9783036597140_41 |