Clinical Applications of Metronomic Chemotherapy
Metronomic chemotherapy is now, finally, in clinical use. After 20 years of preclinical development and clinical trials, the emerging data will be of paramount importance in allowing us to assess the impact of metronomic chemotherapy on different tumor types. Indeed, it is likely that the next decad...
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| Μορφή: | Online |
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| Γλώσσα: | Αγγλικά |
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MDPI - Multidisciplinary Digital Publishing Institute
2024
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| Διαθέσιμο Online: | ONIX_20240108_9783036592800_75 |
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| _version_ | 1869524281715589120 |
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| collection | Directory of Open Access Books |
| description | Metronomic chemotherapy is now, finally, in clinical use. After 20 years of preclinical development and clinical trials, the emerging data will be of paramount importance in allowing us to assess the impact of metronomic chemotherapy on different tumor types. Indeed, it is likely that the next decade will see a major reassessment of the possible applications of metronomic chemotherapy, both alone and in combination with new therapeutic approaches such as immunotherapies, for the management of cancer. Moreover, the results of clinical trials will likely profoundly affect the direction of the laboratory efforts that are going on in parallel and aiming to improve the personalization of this therapeutic strategy. This Special Issue is our attempt to cover the past and present clinical results that have brought us to this pivotal moment and will form the basis of future clinical developments. Scientists and clinicians caring for cancer patients are well aware of the challenges in dealing with this particular therapeutic approach; one such challenge is obtaining improvements in patient survival without significant toxicity. This edition includes clinical research on chemotherapy and ongoing controversies related to metronomic chemotherapy. |
| format | Online |
| id | doab-20.500.12854ir-132416 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1324162024-03-31T13:10:42Z Clinical Applications of Metronomic Chemotherapy Bocci, Guido Francia, Giulio metronomic oral cancer oral squamous cell carcinoma metronomic chemotherapy metastatic castration-resistant prostate cancer cyclophosphamide side effects pediatric tumors etoposide valproic acid prostate cancer CRPC castration capecitabine paclitaxel immunomodulation angiogenesis microbiome breast cancer safety preclinical studies clinical studies pharmacokinetic studies biomarkers chemo-free DLBCL diffuse-large-b-cell-lymphoma elderly frail comprehensive geriatric assessment chemo-endocrine therapy FulVEC pediatric oncology brain tumors pharmacology medulloblastoma ATRT immunotherapy lymphoma vinorelbine checkpoint inhibitors thema EDItEUR::M Medicine and Nursing Metronomic chemotherapy is now, finally, in clinical use. After 20 years of preclinical development and clinical trials, the emerging data will be of paramount importance in allowing us to assess the impact of metronomic chemotherapy on different tumor types. Indeed, it is likely that the next decade will see a major reassessment of the possible applications of metronomic chemotherapy, both alone and in combination with new therapeutic approaches such as immunotherapies, for the management of cancer. Moreover, the results of clinical trials will likely profoundly affect the direction of the laboratory efforts that are going on in parallel and aiming to improve the personalization of this therapeutic strategy. This Special Issue is our attempt to cover the past and present clinical results that have brought us to this pivotal moment and will form the basis of future clinical developments. Scientists and clinicians caring for cancer patients are well aware of the challenges in dealing with this particular therapeutic approach; one such challenge is obtaining improvements in patient survival without significant toxicity. This edition includes clinical research on chemotherapy and ongoing controversies related to metronomic chemotherapy. 2024-01-08T14:48:58Z 2024-01-08T14:48:58Z 2023 book ONIX_20240108_9783036592800_75 9783036592800 9783036592817 https://directory.doabooks.org/handle/20.500.12854/132416 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/8451 https://mdpi.com/books/pdfview/book/8451 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-9281-7 10.3390/books978-3-0365-9281-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036592800 9783036592817 176 Basel open access |
| spellingShingle | metronomic oral cancer oral squamous cell carcinoma metronomic chemotherapy metastatic castration-resistant prostate cancer cyclophosphamide side effects pediatric tumors etoposide valproic acid prostate cancer CRPC castration capecitabine paclitaxel immunomodulation angiogenesis microbiome breast cancer safety preclinical studies clinical studies pharmacokinetic studies biomarkers chemo-free DLBCL diffuse-large-b-cell-lymphoma elderly frail comprehensive geriatric assessment chemo-endocrine therapy FulVEC pediatric oncology brain tumors pharmacology medulloblastoma ATRT immunotherapy lymphoma vinorelbine checkpoint inhibitors thema EDItEUR::M Medicine and Nursing Clinical Applications of Metronomic Chemotherapy |
| title | Clinical Applications of Metronomic Chemotherapy |
| title_full | Clinical Applications of Metronomic Chemotherapy |
| title_fullStr | Clinical Applications of Metronomic Chemotherapy |
| title_full_unstemmed | Clinical Applications of Metronomic Chemotherapy |
| title_short | Clinical Applications of Metronomic Chemotherapy |
| title_sort | clinical applications of metronomic chemotherapy |
| topic | metronomic oral cancer oral squamous cell carcinoma metronomic chemotherapy metastatic castration-resistant prostate cancer cyclophosphamide side effects pediatric tumors etoposide valproic acid prostate cancer CRPC castration capecitabine paclitaxel immunomodulation angiogenesis microbiome breast cancer safety preclinical studies clinical studies pharmacokinetic studies biomarkers chemo-free DLBCL diffuse-large-b-cell-lymphoma elderly frail comprehensive geriatric assessment chemo-endocrine therapy FulVEC pediatric oncology brain tumors pharmacology medulloblastoma ATRT immunotherapy lymphoma vinorelbine checkpoint inhibitors thema EDItEUR::M Medicine and Nursing |
| topic_facet | metronomic oral cancer oral squamous cell carcinoma metronomic chemotherapy metastatic castration-resistant prostate cancer cyclophosphamide side effects pediatric tumors etoposide valproic acid prostate cancer CRPC castration capecitabine paclitaxel immunomodulation angiogenesis microbiome breast cancer safety preclinical studies clinical studies pharmacokinetic studies biomarkers chemo-free DLBCL diffuse-large-b-cell-lymphoma elderly frail comprehensive geriatric assessment chemo-endocrine therapy FulVEC pediatric oncology brain tumors pharmacology medulloblastoma ATRT immunotherapy lymphoma vinorelbine checkpoint inhibitors thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20240108_9783036592800_75 |