Oral Cancer: From Pathophysiology to Novel Therapeutic Approaches
Oral cancer is a commonly occurring head and neck cancer, with 90% of cases diagnosed as oral squamous cell carcinoma (OSCC). Histologically, OSCC is derived from a multistep mechanism known as oral carcinogenesis, which progresses from normal epithelium to hyperplasia, followed by dysplasia and car...
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| Sprog: | engelsk |
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MDPI - Multidisciplinary Digital Publishing Institute
2024
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| Online adgang: | ONIX_20240108_9783036597904_93 |
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| description | Oral cancer is a commonly occurring head and neck cancer, with 90% of cases diagnosed as oral squamous cell carcinoma (OSCC). Histologically, OSCC is derived from a multistep mechanism known as oral carcinogenesis, which progresses from normal epithelium to hyperplasia, followed by dysplasia and carcinoma in situ, and precedes the development of invasive squamous cell carcinoma. This multistep mechanism is characterized by mutations related to copy number alteration and epigenetic modifications. Precision medicine based on genomic profiling is also becoming more prevalent. It relies on the genetic information of individual patients or specific cancer cells and how their genes interact with each other and the environment. This method can potentially provide more effective treatment strategies as approaches can be customized for the specific genetic profiles of patients. Completing the TCGA HNSCC database has led to the development of new therapeutic approaches and targeted therapies. Lately, immune checkpoint inhibitors have been recognized as one of the standards of care in HNSCC. However, although treating invasive SCC is crucial, implementing prevention strategies to preclude malignant transformation has been useful in clinical management. Topics of interest for this Special Issue include, but are not limited to: Precision medicine, i.e., targeted therapies that inhibit oral carcinogenesis and tumorigenesis mechanisms; Combination of novel therapeutic approaches with standard-of-care regimens in OSCC; Biomarkers, i.e., predictive and prognostic markers for therapeutic approaches. |
| format | Online |
| id | doab-20.500.12854ir-132434 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1324342024-03-28T03:33:44Z Oral Cancer: From Pathophysiology to Novel Therapeutic Approaches Vincent-Chong, Vui King oral carcinogenesis oral tumorigenesis oral squamous cell carcinoma immune checkpoint inhibitor mutation biomarkers chemoradiation targeted therapies cisplatin preclinical models deep learning thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Oral cancer is a commonly occurring head and neck cancer, with 90% of cases diagnosed as oral squamous cell carcinoma (OSCC). Histologically, OSCC is derived from a multistep mechanism known as oral carcinogenesis, which progresses from normal epithelium to hyperplasia, followed by dysplasia and carcinoma in situ, and precedes the development of invasive squamous cell carcinoma. This multistep mechanism is characterized by mutations related to copy number alteration and epigenetic modifications. Precision medicine based on genomic profiling is also becoming more prevalent. It relies on the genetic information of individual patients or specific cancer cells and how their genes interact with each other and the environment. This method can potentially provide more effective treatment strategies as approaches can be customized for the specific genetic profiles of patients. Completing the TCGA HNSCC database has led to the development of new therapeutic approaches and targeted therapies. Lately, immune checkpoint inhibitors have been recognized as one of the standards of care in HNSCC. However, although treating invasive SCC is crucial, implementing prevention strategies to preclude malignant transformation has been useful in clinical management. Topics of interest for this Special Issue include, but are not limited to: Precision medicine, i.e., targeted therapies that inhibit oral carcinogenesis and tumorigenesis mechanisms; Combination of novel therapeutic approaches with standard-of-care regimens in OSCC; Biomarkers, i.e., predictive and prognostic markers for therapeutic approaches. 2024-01-08T14:51:33Z 2024-01-08T14:51:33Z 2023 book ONIX_20240108_9783036597904_93 9783036597904 9783036597911 https://directory.doabooks.org/handle/20.500.12854/132434 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/8472 https://mdpi.com/books/pdfview/book/8472 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-9791-1 10.3390/books978-3-0365-9791-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036597904 9783036597911 198 Basel open access |
| spellingShingle | oral carcinogenesis oral tumorigenesis oral squamous cell carcinoma immune checkpoint inhibitor mutation biomarkers chemoradiation targeted therapies cisplatin preclinical models deep learning thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Oral Cancer: From Pathophysiology to Novel Therapeutic Approaches |
| title | Oral Cancer: From Pathophysiology to Novel Therapeutic Approaches |
| title_full | Oral Cancer: From Pathophysiology to Novel Therapeutic Approaches |
| title_fullStr | Oral Cancer: From Pathophysiology to Novel Therapeutic Approaches |
| title_full_unstemmed | Oral Cancer: From Pathophysiology to Novel Therapeutic Approaches |
| title_short | Oral Cancer: From Pathophysiology to Novel Therapeutic Approaches |
| title_sort | oral cancer from pathophysiology to novel therapeutic approaches |
| topic | oral carcinogenesis oral tumorigenesis oral squamous cell carcinoma immune checkpoint inhibitor mutation biomarkers chemoradiation targeted therapies cisplatin preclinical models deep learning thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | oral carcinogenesis oral tumorigenesis oral squamous cell carcinoma immune checkpoint inhibitor mutation biomarkers chemoradiation targeted therapies cisplatin preclinical models deep learning thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20240108_9783036597904_93 |