New Frontiers in Therapeutic Drug Monitoring of Biologics in Inflammatory Bowel Disease and Other Immune-Mediated Inflammatory Diseases
Therapeutic drug monitoring (TDM) has emerged as a useful tool for optimizing biological treatment in patients with inflammatory bowel disease (IBD) and other immune-mediated inflammatory diseases (IMID). Reactive TDM has rationalized the management of primary non-response and secondary loss of resp...
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| Formato: | Online |
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| Idioma: | inglês |
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MDPI - Multidisciplinary Digital Publishing Institute
2024
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| Acesso em linha: | ONIX_20240108_9783036598437_123 |
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| collection | Directory of Open Access Books |
| description | Therapeutic drug monitoring (TDM) has emerged as a useful tool for optimizing biological treatment in patients with inflammatory bowel disease (IBD) and other immune-mediated inflammatory diseases (IMID). Reactive TDM has rationalized the management of primary non-response and secondary loss of response to biologics, while cumulative evidence suggests that proactive TDM is efficacious for optimizing anti-tumour necrosis factor (anti-TNF) therapy in patients with IBD. Proactive TDM can be very useful for optimizing biological therapy in specific IBD populations, such as pregnant women as well as patients with perianal fistulizing Crohn’s disease and acute severe ulcerative colitis who are characterized by high drug clearance. Preliminary data suggest that proactive TDM may also have a role in de-escalating anti-TNF therapy in patients in clinical remission including stopping the immunomodulator when combined with anti-TNF therapy. However, several knowledge gaps and limitations hinder the wide implementation of TDM in clinical practice, including the optimal drug concentration to target the lag time between sampling and results and the lack of harmonization of TDM assays. Recent advances regarding the role of TDM include the use of rapid point-of-care assays and the incorporation of model-informed precision dosing. The aim of this Special Issue is to highlight the clinical utility of TDM and discuss the barriers and recent advances of TDM of biologics in IBD and other IMID. |
| format | Online |
| id | doab-20.500.12854ir-132464 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1324642024-03-30T23:23:01Z New Frontiers in Therapeutic Drug Monitoring of Biologics in Inflammatory Bowel Disease and Other Immune-Mediated Inflammatory Diseases Papamichael, Konstantinos ulcerative colitis Crohn&rsquo s disease inflammatory bowel disease infliximab adalimumab certolizumab pegol golimumab vedolizumab ustekinumab therapeutic drug monitoring immunogenicity rheumatoid arthritis ankylosing spondylitis psoriasis clearance model informed precision dosing thema EDItEUR::M Medicine and Nursing Therapeutic drug monitoring (TDM) has emerged as a useful tool for optimizing biological treatment in patients with inflammatory bowel disease (IBD) and other immune-mediated inflammatory diseases (IMID). Reactive TDM has rationalized the management of primary non-response and secondary loss of response to biologics, while cumulative evidence suggests that proactive TDM is efficacious for optimizing anti-tumour necrosis factor (anti-TNF) therapy in patients with IBD. Proactive TDM can be very useful for optimizing biological therapy in specific IBD populations, such as pregnant women as well as patients with perianal fistulizing Crohn’s disease and acute severe ulcerative colitis who are characterized by high drug clearance. Preliminary data suggest that proactive TDM may also have a role in de-escalating anti-TNF therapy in patients in clinical remission including stopping the immunomodulator when combined with anti-TNF therapy. However, several knowledge gaps and limitations hinder the wide implementation of TDM in clinical practice, including the optimal drug concentration to target the lag time between sampling and results and the lack of harmonization of TDM assays. Recent advances regarding the role of TDM include the use of rapid point-of-care assays and the incorporation of model-informed precision dosing. The aim of this Special Issue is to highlight the clinical utility of TDM and discuss the barriers and recent advances of TDM of biologics in IBD and other IMID. 2024-01-08T14:55:59Z 2024-01-08T14:55:59Z 2023 book ONIX_20240108_9783036598437_123 9783036598437 9783036598444 https://directory.doabooks.org/handle/20.500.12854/132464 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/8504 https://mdpi.com/books/pdfview/book/8504 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-9844-4 10.3390/books978-3-0365-9844-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036598437 9783036598444 174 Basel open access |
| spellingShingle | ulcerative colitis Crohn&rsquo s disease inflammatory bowel disease infliximab adalimumab certolizumab pegol golimumab vedolizumab ustekinumab therapeutic drug monitoring immunogenicity rheumatoid arthritis ankylosing spondylitis psoriasis clearance model informed precision dosing thema EDItEUR::M Medicine and Nursing New Frontiers in Therapeutic Drug Monitoring of Biologics in Inflammatory Bowel Disease and Other Immune-Mediated Inflammatory Diseases |
| title | New Frontiers in Therapeutic Drug Monitoring of Biologics in Inflammatory Bowel Disease and Other Immune-Mediated Inflammatory Diseases |
| title_full | New Frontiers in Therapeutic Drug Monitoring of Biologics in Inflammatory Bowel Disease and Other Immune-Mediated Inflammatory Diseases |
| title_fullStr | New Frontiers in Therapeutic Drug Monitoring of Biologics in Inflammatory Bowel Disease and Other Immune-Mediated Inflammatory Diseases |
| title_full_unstemmed | New Frontiers in Therapeutic Drug Monitoring of Biologics in Inflammatory Bowel Disease and Other Immune-Mediated Inflammatory Diseases |
| title_short | New Frontiers in Therapeutic Drug Monitoring of Biologics in Inflammatory Bowel Disease and Other Immune-Mediated Inflammatory Diseases |
| title_sort | new frontiers in therapeutic drug monitoring of biologics in inflammatory bowel disease and other immune mediated inflammatory diseases |
| topic | ulcerative colitis Crohn&rsquo s disease inflammatory bowel disease infliximab adalimumab certolizumab pegol golimumab vedolizumab ustekinumab therapeutic drug monitoring immunogenicity rheumatoid arthritis ankylosing spondylitis psoriasis clearance model informed precision dosing thema EDItEUR::M Medicine and Nursing |
| topic_facet | ulcerative colitis Crohn&rsquo s disease inflammatory bowel disease infliximab adalimumab certolizumab pegol golimumab vedolizumab ustekinumab therapeutic drug monitoring immunogenicity rheumatoid arthritis ankylosing spondylitis psoriasis clearance model informed precision dosing thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20240108_9783036598437_123 |