Steroid Compounds with Potential Biological Activity
Steroids are a large group of compounds whose structure is based on a 17-carbon skeleton, with a specific cyclopentanoperhydrophenanthrene ring system. Natural steroids have been fine-tuned through evolution to build membranes; act as chemical messengers that regulate metabolic, immune and reproduct...
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| Formato: | Online |
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| Idioma: | inglés |
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MDPI - Multidisciplinary Digital Publishing Institute
2024
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| Acceso en liña: | ONIX_20240108_9783036596174_126 |
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| collection | Directory of Open Access Books |
| description | Steroids are a large group of compounds whose structure is based on a 17-carbon skeleton, with a specific cyclopentanoperhydrophenanthrene ring system. Natural steroids have been fine-tuned through evolution to build membranes; act as chemical messengers that regulate metabolic, immune and reproductive functions in animals and stimulate the growth of, or otherwise protect, animal organisms. The steroid core represents a suitable motive for structural modifications. Therefore, a large group of semi-synthetic steroid derivatives have occupied the attention of synthetic chemists as well as medicinal chemists due to their potential biological activity, including anticancer, antibacterial, anti-inflammatory and (anti)hormonal activities.This Reprint of the Special Issue of Molecules titled “Steroid Compounds with Potential Biological Activity” is dedicated to both experimental and theoretical studies on steroid chemistry, structural biology, biosynthesis, metabolism, and pharmacology. The Issue focuses on the isolation and synthesis of steroid compounds, diverse in origin, as well as their structural characterization and identification. Published articles and reviews relate to in vitro and in silico studies of the pharmacological properties, molecular biology, biochemistry and structural biology of steroids. |
| format | Online |
| id | doab-20.500.12854ir-132467 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1324672024-03-28T03:30:39Z Steroid Compounds with Potential Biological Activity Savić, Marina Mernyák, Erzsébet Ajdukovic, Jovana Jovanović-Šanta, Suzana 4-azasteroids 4-azapregnenes aldol condensation molecular docking antiproliferative activity Paracaudina chilensis Molpadida triterpene glycosides chilensosides sea cucumber cytotoxic activity 26-thiodiosgenin thiol oxidation sulfoxides sulfones sapogenins steroids antimicrobial activity cytotoxicity breast cancer endocrine therapy endocrine resistance aromatase inhibitors exemestane oxymestane anti-cancer properties multi-target compounds aromatase estrogen receptor androgen receptor Chan–Lam reaction diaryl ether 13α-estrone antiproliferative effect tubulin polymerization molecular dynamics oximes chemistry antitumor anti-inflammatory antibacterial antifungal antiviral triterpenoids isoprenoid lipids anti-neoplastic anti-fungal anti-bacterial anti-viral fungal endophytes plants marine invertebrates furanosteroids fungi marine organisms diacetoxy-5α-cholestane crystal structure HSA binding multi-spectroscopy DFT steroid dimers 1,4-phenylene-linked dimers montmorillonite DHEA cholesterol cation channels TRPML1 bioisostere estrogens ring cleavage protective groups pyridines pyrimidines cyclization antimetabolites cell growth inhibition gene expression HeLa cells in vitro culture thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Steroids are a large group of compounds whose structure is based on a 17-carbon skeleton, with a specific cyclopentanoperhydrophenanthrene ring system. Natural steroids have been fine-tuned through evolution to build membranes; act as chemical messengers that regulate metabolic, immune and reproductive functions in animals and stimulate the growth of, or otherwise protect, animal organisms. The steroid core represents a suitable motive for structural modifications. Therefore, a large group of semi-synthetic steroid derivatives have occupied the attention of synthetic chemists as well as medicinal chemists due to their potential biological activity, including anticancer, antibacterial, anti-inflammatory and (anti)hormonal activities.This Reprint of the Special Issue of Molecules titled “Steroid Compounds with Potential Biological Activity” is dedicated to both experimental and theoretical studies on steroid chemistry, structural biology, biosynthesis, metabolism, and pharmacology. The Issue focuses on the isolation and synthesis of steroid compounds, diverse in origin, as well as their structural characterization and identification. Published articles and reviews relate to in vitro and in silico studies of the pharmacological properties, molecular biology, biochemistry and structural biology of steroids. 2024-01-08T14:56:16Z 2024-01-08T14:56:16Z 2023 book ONIX_20240108_9783036596174_126 9783036596174 9783036596167 https://directory.doabooks.org/handle/20.500.12854/132467 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/8522 https://mdpi.com/books/pdfview/book/8522 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-9616-7 10.3390/books978-3-0365-9616-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036596174 9783036596167 318 Basel open access |
| spellingShingle | 4-azasteroids 4-azapregnenes aldol condensation molecular docking antiproliferative activity Paracaudina chilensis Molpadida triterpene glycosides chilensosides sea cucumber cytotoxic activity 26-thiodiosgenin thiol oxidation sulfoxides sulfones sapogenins steroids antimicrobial activity cytotoxicity breast cancer endocrine therapy endocrine resistance aromatase inhibitors exemestane oxymestane anti-cancer properties multi-target compounds aromatase estrogen receptor androgen receptor Chan–Lam reaction diaryl ether 13α-estrone antiproliferative effect tubulin polymerization molecular dynamics oximes chemistry antitumor anti-inflammatory antibacterial antifungal antiviral triterpenoids isoprenoid lipids anti-neoplastic anti-fungal anti-bacterial anti-viral fungal endophytes plants marine invertebrates furanosteroids fungi marine organisms diacetoxy-5α-cholestane crystal structure HSA binding multi-spectroscopy DFT steroid dimers 1,4-phenylene-linked dimers montmorillonite DHEA cholesterol cation channels TRPML1 bioisostere estrogens ring cleavage protective groups pyridines pyrimidines cyclization antimetabolites cell growth inhibition gene expression HeLa cells in vitro culture thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Steroid Compounds with Potential Biological Activity |
| title | Steroid Compounds with Potential Biological Activity |
| title_full | Steroid Compounds with Potential Biological Activity |
| title_fullStr | Steroid Compounds with Potential Biological Activity |
| title_full_unstemmed | Steroid Compounds with Potential Biological Activity |
| title_short | Steroid Compounds with Potential Biological Activity |
| title_sort | steroid compounds with potential biological activity |
| topic | 4-azasteroids 4-azapregnenes aldol condensation molecular docking antiproliferative activity Paracaudina chilensis Molpadida triterpene glycosides chilensosides sea cucumber cytotoxic activity 26-thiodiosgenin thiol oxidation sulfoxides sulfones sapogenins steroids antimicrobial activity cytotoxicity breast cancer endocrine therapy endocrine resistance aromatase inhibitors exemestane oxymestane anti-cancer properties multi-target compounds aromatase estrogen receptor androgen receptor Chan–Lam reaction diaryl ether 13α-estrone antiproliferative effect tubulin polymerization molecular dynamics oximes chemistry antitumor anti-inflammatory antibacterial antifungal antiviral triterpenoids isoprenoid lipids anti-neoplastic anti-fungal anti-bacterial anti-viral fungal endophytes plants marine invertebrates furanosteroids fungi marine organisms diacetoxy-5α-cholestane crystal structure HSA binding multi-spectroscopy DFT steroid dimers 1,4-phenylene-linked dimers montmorillonite DHEA cholesterol cation channels TRPML1 bioisostere estrogens ring cleavage protective groups pyridines pyrimidines cyclization antimetabolites cell growth inhibition gene expression HeLa cells in vitro culture thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | 4-azasteroids 4-azapregnenes aldol condensation molecular docking antiproliferative activity Paracaudina chilensis Molpadida triterpene glycosides chilensosides sea cucumber cytotoxic activity 26-thiodiosgenin thiol oxidation sulfoxides sulfones sapogenins steroids antimicrobial activity cytotoxicity breast cancer endocrine therapy endocrine resistance aromatase inhibitors exemestane oxymestane anti-cancer properties multi-target compounds aromatase estrogen receptor androgen receptor Chan–Lam reaction diaryl ether 13α-estrone antiproliferative effect tubulin polymerization molecular dynamics oximes chemistry antitumor anti-inflammatory antibacterial antifungal antiviral triterpenoids isoprenoid lipids anti-neoplastic anti-fungal anti-bacterial anti-viral fungal endophytes plants marine invertebrates furanosteroids fungi marine organisms diacetoxy-5α-cholestane crystal structure HSA binding multi-spectroscopy DFT steroid dimers 1,4-phenylene-linked dimers montmorillonite DHEA cholesterol cation channels TRPML1 bioisostere estrogens ring cleavage protective groups pyridines pyrimidines cyclization antimetabolites cell growth inhibition gene expression HeLa cells in vitro culture thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20240108_9783036596174_126 |