Solving the Puzzle: Molecular Research in Inflammatory Bowel Diseases
Inflammatory bowel disease (IBD) encompasses chronic idiopathic relapsing and remitting gastrointestinal autoimmune diseases characterized by chronic inflammatory disorders of complex etiology, posing clinical challenges due to their often therapy-refractory nature. The primary disorders within the...
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| Format: | Online |
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| Jezik: | engleski |
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MDPI - Multidisciplinary Digital Publishing Institute
2024
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| Online pristup: | ONIX_20240108_9783036598642_135 |
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| collection | Directory of Open Access Books |
| description | Inflammatory bowel disease (IBD) encompasses chronic idiopathic relapsing and remitting gastrointestinal autoimmune diseases characterized by chronic inflammatory disorders of complex etiology, posing clinical challenges due to their often therapy-refractory nature. The primary disorders within the IBD classification are ulcerative colitis (UC) and Crohn’s disease (CD), sharing similarities but exhibiting distinct differences, sometimes making their discrimination challenging.A prominent feature of IBD is the inflammation of the intestinal mucosa, characterized by the robust and persistent infiltration of immune cells and compromised intestinal barrier integrity, leading to a phenomenon known as “leaky gut.” Inflammation can manifest acutely or chronically, known as relapsing, and can increase in severity over time, thereby causing life-long morbidities and reduced quality of life for affected individuals, underscoring the need for a deeper comprehension of the molecular contributors to disease pathogenesis and progression. |
| format | Online |
| id | doab-20.500.12854ir-132476 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1324762024-03-30T23:22:48Z Solving the Puzzle: Molecular Research in Inflammatory Bowel Diseases Krug, Susanne M. inflammatory bowel diseases cell autofluorescence immune cells NADH FAD flow cytometry multiphoton microscopy colitis colitis-associated cancer inflammatory bowel disease colorectal cancer colon adenocarcinoma ulcerative colitis Crohn’s disease cDNA microarray transciptomics analysis microarray inflammatory bowel diseases (IBDs) vasculature angiogenesis gut vascular barrier vessel permeability epithelial barrier homeostasis acetylcholine muscarinic receptor non-neuronal acetylcholine mucosal wound healing ferroptosis leaky gut inflammatory bowel disease (IBD) triple-culture Caco-2 HT29-MTX-E12 THP-1 monocyte-derived macrophage inflammation TEER FITC-dextran 4 kDa (FD4) pro-inflammatory cytokines HIF-1α PHD2 AKT intestinal epithelial cells probiotics LPS antigen-specific T-cells celiac disease gliadin IBD food antigens intestinal Behcet’s disease immune mechanism biological agents claudin tight junctions barrier function gut ZO-1 actin cell migration cell division colon cancer PMNs LDs FOXO3 n/a thema EDItEUR::M Medicine and Nursing Inflammatory bowel disease (IBD) encompasses chronic idiopathic relapsing and remitting gastrointestinal autoimmune diseases characterized by chronic inflammatory disorders of complex etiology, posing clinical challenges due to their often therapy-refractory nature. The primary disorders within the IBD classification are ulcerative colitis (UC) and Crohn’s disease (CD), sharing similarities but exhibiting distinct differences, sometimes making their discrimination challenging.A prominent feature of IBD is the inflammation of the intestinal mucosa, characterized by the robust and persistent infiltration of immune cells and compromised intestinal barrier integrity, leading to a phenomenon known as “leaky gut.” Inflammation can manifest acutely or chronically, known as relapsing, and can increase in severity over time, thereby causing life-long morbidities and reduced quality of life for affected individuals, underscoring the need for a deeper comprehension of the molecular contributors to disease pathogenesis and progression. 2024-01-08T14:57:37Z 2024-01-08T14:57:37Z 2023 book ONIX_20240108_9783036598642_135 9783036598642 9783036598635 https://directory.doabooks.org/handle/20.500.12854/132476 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/8531 https://mdpi.com/books/pdfview/book/8531 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-9863-5 10.3390/books978-3-0365-9863-5 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036598642 9783036598635 204 Basel open access |
| spellingShingle | inflammatory bowel diseases cell autofluorescence immune cells NADH FAD flow cytometry multiphoton microscopy colitis colitis-associated cancer inflammatory bowel disease colorectal cancer colon adenocarcinoma ulcerative colitis Crohn’s disease cDNA microarray transciptomics analysis microarray inflammatory bowel diseases (IBDs) vasculature angiogenesis gut vascular barrier vessel permeability epithelial barrier homeostasis acetylcholine muscarinic receptor non-neuronal acetylcholine mucosal wound healing ferroptosis leaky gut inflammatory bowel disease (IBD) triple-culture Caco-2 HT29-MTX-E12 THP-1 monocyte-derived macrophage inflammation TEER FITC-dextran 4 kDa (FD4) pro-inflammatory cytokines HIF-1α PHD2 AKT intestinal epithelial cells probiotics LPS antigen-specific T-cells celiac disease gliadin IBD food antigens intestinal Behcet’s disease immune mechanism biological agents claudin tight junctions barrier function gut ZO-1 actin cell migration cell division colon cancer PMNs LDs FOXO3 n/a thema EDItEUR::M Medicine and Nursing Solving the Puzzle: Molecular Research in Inflammatory Bowel Diseases |
| title | Solving the Puzzle: Molecular Research in Inflammatory Bowel Diseases |
| title_full | Solving the Puzzle: Molecular Research in Inflammatory Bowel Diseases |
| title_fullStr | Solving the Puzzle: Molecular Research in Inflammatory Bowel Diseases |
| title_full_unstemmed | Solving the Puzzle: Molecular Research in Inflammatory Bowel Diseases |
| title_short | Solving the Puzzle: Molecular Research in Inflammatory Bowel Diseases |
| title_sort | solving the puzzle molecular research in inflammatory bowel diseases |
| topic | inflammatory bowel diseases cell autofluorescence immune cells NADH FAD flow cytometry multiphoton microscopy colitis colitis-associated cancer inflammatory bowel disease colorectal cancer colon adenocarcinoma ulcerative colitis Crohn’s disease cDNA microarray transciptomics analysis microarray inflammatory bowel diseases (IBDs) vasculature angiogenesis gut vascular barrier vessel permeability epithelial barrier homeostasis acetylcholine muscarinic receptor non-neuronal acetylcholine mucosal wound healing ferroptosis leaky gut inflammatory bowel disease (IBD) triple-culture Caco-2 HT29-MTX-E12 THP-1 monocyte-derived macrophage inflammation TEER FITC-dextran 4 kDa (FD4) pro-inflammatory cytokines HIF-1α PHD2 AKT intestinal epithelial cells probiotics LPS antigen-specific T-cells celiac disease gliadin IBD food antigens intestinal Behcet’s disease immune mechanism biological agents claudin tight junctions barrier function gut ZO-1 actin cell migration cell division colon cancer PMNs LDs FOXO3 n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | inflammatory bowel diseases cell autofluorescence immune cells NADH FAD flow cytometry multiphoton microscopy colitis colitis-associated cancer inflammatory bowel disease colorectal cancer colon adenocarcinoma ulcerative colitis Crohn’s disease cDNA microarray transciptomics analysis microarray inflammatory bowel diseases (IBDs) vasculature angiogenesis gut vascular barrier vessel permeability epithelial barrier homeostasis acetylcholine muscarinic receptor non-neuronal acetylcholine mucosal wound healing ferroptosis leaky gut inflammatory bowel disease (IBD) triple-culture Caco-2 HT29-MTX-E12 THP-1 monocyte-derived macrophage inflammation TEER FITC-dextran 4 kDa (FD4) pro-inflammatory cytokines HIF-1α PHD2 AKT intestinal epithelial cells probiotics LPS antigen-specific T-cells celiac disease gliadin IBD food antigens intestinal Behcet’s disease immune mechanism biological agents claudin tight junctions barrier function gut ZO-1 actin cell migration cell division colon cancer PMNs LDs FOXO3 n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20240108_9783036598642_135 |