How Does Germline Regenerate?
A concise primer that complicates a convenient truth in biology—the divide between germ and somatic cells—with far-reaching ethical and public policy ramifications. Scientists have long held that we have two kinds of cells—germ and soma. Make a change to germ cells—say using genome editing—and t...
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| פורמט: | Online |
| שפה: | אנגלית |
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University of Chicago Press
2024
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| נושאים: | |
| גישה מקוונת: | OCN: 1407317401 |
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אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!
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| _version_ | 1869518525627891712 |
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| author | MacCord, Kate |
| author_browse | MacCord, Kate |
| author_facet | MacCord, Kate |
| author_sort | MacCord, Kate |
| collection | Directory of Open Access Books |
| description | A concise primer that complicates a convenient truth in biology—the divide between germ and somatic cells—with far-reaching ethical and public policy ramifications.
Scientists have long held that we have two kinds of cells—germ and soma. Make a change to germ cells—say using genome editing—and that change will appear in the cells of future generations. Somatic cells are “safe” after such tampering; modify your skin cells, and your future children’s skin cells will never know. And, while germ cells can give rise to new generations (including all of the somatic cells in a body), somatic cells can never become germ cells. How did scientists discover this relationship and distinction between somatic and germ cells—the so-called Weismann Barrier—and does it actually exist? Can somatic cells become germ cells in the way germ cells become somatic cells? That is, can germ cells regenerate from somatic cells even though conventional wisdom denies this possibility? Covering research from the late nineteenth century to the 2020s, historian and philosopher of science Kate MacCord explores how scientists came to understand and accept the dubious concept of the Weismann Barrier and what profound implications this convenient assumption has for research and policy, from genome editing to stem cell research, and much more. |
| format | Online |
| id | doab-20.500.12854ir-132494 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | University of Chicago Press |
| publisherStr | University of Chicago Press |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1324942025-03-22T13:08:03Z How Does Germline Regenerate? MacCord, Kate germline, germ cell, regeneration, genome editing, cell lineage, Weismann Barrier, August Weismann, germ plasm theory A concise primer that complicates a convenient truth in biology—the divide between germ and somatic cells—with far-reaching ethical and public policy ramifications. Scientists have long held that we have two kinds of cells—germ and soma. Make a change to germ cells—say using genome editing—and that change will appear in the cells of future generations. Somatic cells are “safe” after such tampering; modify your skin cells, and your future children’s skin cells will never know. And, while germ cells can give rise to new generations (including all of the somatic cells in a body), somatic cells can never become germ cells. How did scientists discover this relationship and distinction between somatic and germ cells—the so-called Weismann Barrier—and does it actually exist? Can somatic cells become germ cells in the way germ cells become somatic cells? That is, can germ cells regenerate from somatic cells even though conventional wisdom denies this possibility? Covering research from the late nineteenth century to the 2020s, historian and philosopher of science Kate MacCord explores how scientists came to understand and accept the dubious concept of the Weismann Barrier and what profound implications this convenient assumption has for research and policy, from genome editing to stem cell research, and much more. 2024-01-09T13:45:50Z 2024-01-09T13:45:50Z 2024-01-08T11:12:25Z 2024 book OCN: 1407317401 https://library.oapen.org/handle/20.500.12657/86473 9780226830490 9780226830513 https://directory.doabooks.org/handle/20.500.12854/132494 eng Convening Science: Discovery at the Marine Biological Laboratory open access image/jpeg image/jpeg image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International Attribution-NonCommercial-NoDerivatives 4.0 International Attribution-NonCommercial-NoDerivatives 4.0 International https://library.oapen.org/bitstream/20.500.12657/86473/1/9780226830506.pdf https://library.oapen.org/bitstream/20.500.12657/86473/1/9780226830506.pdf https://library.oapen.org/bitstream/20.500.12657/86473/1/9780226830506.pdf University of Chicago Press 10.7208/chicago/9780226830506.001.0001 10.7208/chicago/9780226830506.001.0001 decd55ad-cee8-4380-ad0e-0ead8a496f4d 9780226830490 9780226830513 172 open access |
| spellingShingle | germline, germ cell, regeneration, genome editing, cell lineage, Weismann Barrier, August Weismann, germ plasm theory MacCord, Kate How Does Germline Regenerate? |
| title | How Does Germline Regenerate? |
| title_full | How Does Germline Regenerate? |
| title_fullStr | How Does Germline Regenerate? |
| title_full_unstemmed | How Does Germline Regenerate? |
| title_short | How Does Germline Regenerate? |
| title_sort | how does germline regenerate |
| topic | germline, germ cell, regeneration, genome editing, cell lineage, Weismann Barrier, August Weismann, germ plasm theory |
| topic_facet | germline, germ cell, regeneration, genome editing, cell lineage, Weismann Barrier, August Weismann, germ plasm theory |
| url | OCN: 1407317401 |
| work_keys_str_mv | AT maccordkate howdoesgermlineregenerate |