Chapter 11 Glutathione Transferases
This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glut...
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| פורמט: | Online |
| שפה: | אנגלית |
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Taylor & Francis
2024
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| גישה מקוונת: | https://library.oapen.org/handle/20.500.12657/87681 |
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| _version_ | 1869528575263113216 |
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| author | Mannervik, Bengt Sjödin, Birgitta |
| author_browse | Mannervik, Bengt Sjödin, Birgitta |
| author_facet | Mannervik, Bengt Sjödin, Birgitta |
| author_sort | Mannervik, Bengt |
| collection | Directory of Open Access Books |
| description | This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione-<I>S</I>-transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets.
Key selling features:
Summarizing the way glutathione is involved in stress responses
Compiling the multiple ways glutathione affects inflammatory responses
Disclosing how glutathione dampens programmed cell death such as ferroptosis
Exploring the enigma of how enzymes accelerate glutathione-dependent processes
Discussing how detoxification and redox regulation is mediated by glutathionylation
Reviewing the ways glutaredoxins catalyze protein disulfide reduction
Highlighting the medical impact of glutathione-related metabolic pathways
Illustrating the role thiol metabolism of pathogens might play in drug discovery |
| format | Online |
| id | doab-20.500.12854ir-134133 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Taylor & Francis |
| publisherStr | Taylor & Francis |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1341332025-07-17T10:00:41Z Chapter 11 Glutathione Transferases Mannervik, Bengt Sjödin, Birgitta MLCP Activation,MLCK Activity,Myosin Head,Airway Smooth Muscle,Actomyosin ATPase Activity,Cross-bridge Cycling,Protein Tyrosine Phosphatase 1B,Protein Tyrosine Phosphatase 1B,GSNOR,Soluble Guanylate Cyclase,Spontaneous PTL,Smooth Muscle,Cognate Kinase,Myometrial Quiescence,Pkg Action,RhoGEF,Cysteine Thiol,SMM,Smooth Muscle Contraction,Myosin Phosphatase,MLCP,Cap Protein,Cardiac Myosin,Regulatory Light Chain,Cox thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSF Cellular biology (cytology) thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSF Cellular biology (cytology) thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione-<I>S</I>-transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets. Key selling features: Summarizing the way glutathione is involved in stress responses Compiling the multiple ways glutathione affects inflammatory responses Disclosing how glutathione dampens programmed cell death such as ferroptosis Exploring the enigma of how enzymes accelerate glutathione-dependent processes Discussing how detoxification and redox regulation is mediated by glutathionylation Reviewing the ways glutaredoxins catalyze protein disulfide reduction Highlighting the medical impact of glutathione-related metabolic pathways Illustrating the role thiol metabolism of pathogens might play in drug discovery 2024-02-15T04:18:52Z 2024-02-15T04:18:52Z 2024-02-14T14:01:52Z 2018 chapter https://library.oapen.org/handle/20.500.12657/87681 9780815365327 9780367656997 https://directory.doabooks.org/handle/20.500.12854/134133 eng open access image/jpeg image/jpeg image/jpeg Attribution 4.0 International Attribution 4.0 International Attribution 4.0 International https://library.oapen.org/bitstream/20.500.12657/87681/1/9781351261760_10.1201_9781351261760-14.pdf https://library.oapen.org/bitstream/20.500.12657/87681/1/9781351261760_10.1201_9781351261760-14.pdf https://library.oapen.org/bitstream/20.500.12657/87681/1/9781351261760_10.1201_9781351261760-14.pdf Taylor & Francis CRC Press 10.1201/9781351261760-14 10.1201/9781351261760-14 fa69b019-f4ee-4979-8d42-c6b6c476b5f0 Glutathione 9780815365327 9780367656997 CRC Press 26 open access |
| spellingShingle | MLCP Activation,MLCK Activity,Myosin Head,Airway Smooth Muscle,Actomyosin ATPase Activity,Cross-bridge Cycling,Protein Tyrosine Phosphatase 1B,Protein Tyrosine Phosphatase 1B,GSNOR,Soluble Guanylate Cyclase,Spontaneous PTL,Smooth Muscle,Cognate Kinase,Myometrial Quiescence,Pkg Action,RhoGEF,Cysteine Thiol,SMM,Smooth Muscle Contraction,Myosin Phosphatase,MLCP,Cap Protein,Cardiac Myosin,Regulatory Light Chain,Cox thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSF Cellular biology (cytology) thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSF Cellular biology (cytology) thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Mannervik, Bengt Sjödin, Birgitta Chapter 11 Glutathione Transferases |
| title | Chapter 11 Glutathione Transferases |
| title_full | Chapter 11 Glutathione Transferases |
| title_fullStr | Chapter 11 Glutathione Transferases |
| title_full_unstemmed | Chapter 11 Glutathione Transferases |
| title_short | Chapter 11 Glutathione Transferases |
| title_sort | chapter 11 glutathione transferases |
| topic | MLCP Activation,MLCK Activity,Myosin Head,Airway Smooth Muscle,Actomyosin ATPase Activity,Cross-bridge Cycling,Protein Tyrosine Phosphatase 1B,Protein Tyrosine Phosphatase 1B,GSNOR,Soluble Guanylate Cyclase,Spontaneous PTL,Smooth Muscle,Cognate Kinase,Myometrial Quiescence,Pkg Action,RhoGEF,Cysteine Thiol,SMM,Smooth Muscle Contraction,Myosin Phosphatase,MLCP,Cap Protein,Cardiac Myosin,Regulatory Light Chain,Cox thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSF Cellular biology (cytology) thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSF Cellular biology (cytology) thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | MLCP Activation,MLCK Activity,Myosin Head,Airway Smooth Muscle,Actomyosin ATPase Activity,Cross-bridge Cycling,Protein Tyrosine Phosphatase 1B,Protein Tyrosine Phosphatase 1B,GSNOR,Soluble Guanylate Cyclase,Spontaneous PTL,Smooth Muscle,Cognate Kinase,Myometrial Quiescence,Pkg Action,RhoGEF,Cysteine Thiol,SMM,Smooth Muscle Contraction,Myosin Phosphatase,MLCP,Cap Protein,Cardiac Myosin,Regulatory Light Chain,Cox thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSF Cellular biology (cytology) thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSF Cellular biology (cytology) thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | https://library.oapen.org/handle/20.500.12657/87681 |
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