Drug Metabolism and Pharmacokinetics
This book, Drug Metabolism and Pharmacokinetics, delivers the latest information on biotransformation and other pharmacokinetic parameters required to assess drug safety in drug discovery and development. Drug metabolism and pharmacokinetics (DMPK) is considered a rational strategy for the design, o...
Salvato in:
| Natura: | Online |
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| Lingua: | inglese |
| Pubblicazione: |
IntechOpen
2024
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| Soggetti: | |
| Accesso online: | ONIX_20240307_9780850141481_330 |
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| _version_ | 1869517964373393408 |
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| collection | Directory of Open Access Books |
| description | This book, Drug Metabolism and Pharmacokinetics, delivers the latest information on biotransformation and other pharmacokinetic parameters required to assess drug safety in drug discovery and development. Drug metabolism and pharmacokinetics (DMPK) is considered a rational strategy for the design, optimization, and selection of successful drug candidates in the pre-clinical stages of drug discovery. The evaluation of various pharmacokinetic parameters such as aqueous solubility, lipophilicity, cell permeability, bioavailability, protein binding, and metabolism and elimination half-life, drug–drug interactions (DDIs), and toxicokinetics is essential for a candidate drug to become a successful therapeutic agent. This book discusses recent advances in in-silico tools and in vitro/in vivo experimental techniques applied in pharmacokinetic, metabolomic, and bioanalytical studies. Key Features: • Presents pharmacokinetic and biotransformation parameters used for pre-clinical safety evaluations • Depicts experimental and biophysical techniques used in bioanalytical and metabolomic studies • Summarizes in silico, in vitro, and in vivo methods used in drug–enzyme interactions, drug– drug interactions, and toxicokinetics Written by a global team of experts, this book is a valuable resource for drug discovery scientists, drug developers, medicinal chemists, pharmacologists, biochemists, clinicians, biomedical scientists, healthcare professionals, researchers, teaching faculty, and students. |
| format | Online |
| id | doab-20.500.12854ir-135421 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1354212024-04-01T14:14:52Z Drug Metabolism and Pharmacokinetics Rudrapal, Mithun thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology This book, Drug Metabolism and Pharmacokinetics, delivers the latest information on biotransformation and other pharmacokinetic parameters required to assess drug safety in drug discovery and development. Drug metabolism and pharmacokinetics (DMPK) is considered a rational strategy for the design, optimization, and selection of successful drug candidates in the pre-clinical stages of drug discovery. The evaluation of various pharmacokinetic parameters such as aqueous solubility, lipophilicity, cell permeability, bioavailability, protein binding, and metabolism and elimination half-life, drug–drug interactions (DDIs), and toxicokinetics is essential for a candidate drug to become a successful therapeutic agent. This book discusses recent advances in in-silico tools and in vitro/in vivo experimental techniques applied in pharmacokinetic, metabolomic, and bioanalytical studies. Key Features: • Presents pharmacokinetic and biotransformation parameters used for pre-clinical safety evaluations • Depicts experimental and biophysical techniques used in bioanalytical and metabolomic studies • Summarizes in silico, in vitro, and in vivo methods used in drug–enzyme interactions, drug– drug interactions, and toxicokinetics Written by a global team of experts, this book is a valuable resource for drug discovery scientists, drug developers, medicinal chemists, pharmacologists, biochemists, clinicians, biomedical scientists, healthcare professionals, researchers, teaching faculty, and students. 2024-03-07T17:21:23Z 2024-03-07T17:21:23Z 2024 book ONIX_20240307_9780850141481_330 3033-3318 9780850141481 9780850141474 9780850141498 https://directory.doabooks.org/handle/20.500.12854/135421 eng Pharmaceutical Science image/jpeg n/a https://www.intechopen.com/books/13262 https://mts.intechopen.com/storage/books/13262/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/intechopen.111605 10.5772/intechopen.111605 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9780850141481 9780850141474 9780850141498 IntechOpen 2 134 open access |
| spellingShingle | thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Drug Metabolism and Pharmacokinetics |
| title | Drug Metabolism and Pharmacokinetics |
| title_full | Drug Metabolism and Pharmacokinetics |
| title_fullStr | Drug Metabolism and Pharmacokinetics |
| title_full_unstemmed | Drug Metabolism and Pharmacokinetics |
| title_short | Drug Metabolism and Pharmacokinetics |
| title_sort | drug metabolism and pharmacokinetics |
| topic | thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | ONIX_20240307_9780850141481_330 |